Katherine M Livingstone1, Carlos Celis-Morales1, Santiago Navas-Carretero2, Rodrigo San-Cristobal3, Anna L Macready4, Rosalind Fallaize4, Hannah Forster5, Clara Woolhead5, Clare B O'Donovan5, Cyril Fm Marsaux6, Silvia Kolossa7, Lydia Tsirigoti8, Christina P Lambrinou8, George Moschonis8, Magdalena Godlewska9, Agnieszka Surwiłło9, Christian A Drevon10, Yannis Manios8, Iwona Traczyk9, Eileen R Gibney5, Lorraine Brennan5, Marianne C Walsh5, Julie A Lovegrove4, Wim H Saris6, Hannelore Daniel7, Mike Gibney5, J Alfredo Martinez3, John C Mathers11. 1. Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom; 2. Center for Nutrition Research, University of Navarra, Pamplona, Spain; CIBER Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; 3. CIBER Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; 4. Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom; 5. UCD Institute of Food and Health, University College Dublin, Belfield, Dublin, Republic of Ireland; 6. Department of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, Netherlands; 7. Research Center of Nutrition and Food Sciences (ZIEL), Biochemistry Unit, Technical University of Munich, Munich, Germany; 8. Department of Nutrition and Dietetics, Harokopio University, Athens, Greece; 9. National Food and Nutrition Institute, Poland; and. 10. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway. 11. Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom; john.mathers@newcastle.ac.uk.
Abstract
BACKGROUND: Little is known about the efficacy of personalized nutrition (PN) interventions for improving consumption of a Mediterranean diet (MedDiet). OBJECTIVE: The objective was to evaluate the effect of a PN intervention on dietary changes associated with the MedDiet. DESIGN:Participants (n = 1607) were recruited into a 6-mo, Internet-based, PN randomized controlled trial (Food4Me) designed to evaluate the effect of PN on dietary change. Participants were randomly assigned to receive conventional dietary advice [control; level 0 (L0)] or PN advice on the basis of current diet [level 1 (L1)], diet and phenotype [level 2 (L2)], or diet, phenotype, and genotype [level 3 (L3)]. Dietary intakes from food-frequency questionnaires at baseline and at 6 mo were converted to a MedDiet score. Linear regression compared participant characteristics between high (>5) and low (≤5) MedDiet scores. Differences in MedDiet scores between treatment arms at month 6 were evaluated by using contrast analyses. RESULTS: At baseline, high MedDiet scorers had a 0.5 lower body mass index (in kg/m(2); P = 0.007) and a 0.03 higher physical activity level (P = 0.003) than did low scorers. MedDiet scores at month 6 were greater in individuals randomly assigned to receive PN (L1, L2, and L3) than in controls (PN compared with controls: 5.20 ± 0.05 and 5.48 ± 0.07, respectively; P = 0.002). There was no significant difference in MedDiet scores at month 6 between PN advice on the basis of L1 compared with L2 and L3. However, differences in MedDiet scores at month 6 were greater in L3 than in L2 (L3 compared with L2: 5.63 ± 0.10 and 5.38 ± 0.10, respectively; P = 0.029). CONCLUSIONS:Higher MedDiet scores at baseline were associated with healthier lifestyles and lower adiposity. After the intervention, MedDiet scores were greater in individuals randomly assigned to receive PN than in controls, with the addition of DNA-based dietary advice resulting in the largest differences in MedDiet scores. Although differences were significant, their clinical relevance is modest. This trial was registered at clinicaltrials.gov as NCT01530139.
RCT Entities:
BACKGROUND: Little is known about the efficacy of personalized nutrition (PN) interventions for improving consumption of a Mediterranean diet (MedDiet). OBJECTIVE: The objective was to evaluate the effect of a PN intervention on dietary changes associated with the MedDiet. DESIGN:Participants (n = 1607) were recruited into a 6-mo, Internet-based, PN randomized controlled trial (Food4Me) designed to evaluate the effect of PN on dietary change. Participants were randomly assigned to receive conventional dietary advice [control; level 0 (L0)] or PN advice on the basis of current diet [level 1 (L1)], diet and phenotype [level 2 (L2)], or diet, phenotype, and genotype [level 3 (L3)]. Dietary intakes from food-frequency questionnaires at baseline and at 6 mo were converted to a MedDiet score. Linear regression compared participant characteristics between high (>5) and low (≤5) MedDiet scores. Differences in MedDiet scores between treatment arms at month 6 were evaluated by using contrast analyses. RESULTS: At baseline, high MedDiet scorers had a 0.5 lower body mass index (in kg/m(2); P = 0.007) and a 0.03 higher physical activity level (P = 0.003) than did low scorers. MedDiet scores at month 6 were greater in individuals randomly assigned to receive PN (L1, L2, and L3) than in controls (PN compared with controls: 5.20 ± 0.05 and 5.48 ± 0.07, respectively; P = 0.002). There was no significant difference in MedDiet scores at month 6 between PN advice on the basis of L1 compared with L2 and L3. However, differences in MedDiet scores at month 6 were greater in L3 than in L2 (L3 compared with L2: 5.63 ± 0.10 and 5.38 ± 0.10, respectively; P = 0.029). CONCLUSIONS: Higher MedDiet scores at baseline were associated with healthier lifestyles and lower adiposity. After the intervention, MedDiet scores were greater in individuals randomly assigned to receive PN than in controls, with the addition of DNA-based dietary advice resulting in the largest differences in MedDiet scores. Although differences were significant, their clinical relevance is modest. This trial was registered at clinicaltrials.gov as NCT01530139.
Authors: Yannis Manios; George Moschonis; Christina P Lambrinou; Christina Mavrogianni; Lydia Tsirigoti; Ulrich Hoeller; Franz F Roos; Igor Bendik; Manfred Eggersdorfer; Carlos Celis-Morales; Katherine M Livingstone; Cyril F M Marsaux; Anna L Macready; Rosalind Fallaize; Clare B O'Donovan; Clara Woolhead; Hannah Forster; Marianne C Walsh; Santiago Navas-Carretero; Rodrigo San-Cristobal; Silvia Kolossa; Jacqueline Hallmann; Mirosław Jarosz; Agnieszka Surwiłło; Iwona Traczyk; Christian A Drevon; Ben van Ommen; Keith Grimaldi; John N S Matthews; Hannelore Daniel; J Alfredo Martinez; Julie A Lovegrove; Eileen R Gibney; Lorraine Brennan; Wim H M Saris; Mike Gibney; John C Mathers Journal: Eur J Nutr Date: 2017-03-13 Impact factor: 5.614
Authors: Juntao Kan; Jiayi Ni; Kun Xue; Feijie Wang; Jianheng Zheng; Junrui Cheng; Peiying Wu; Matthew K Runyon; Hongwei Guo; Jun Du Journal: Front Nutr Date: 2022-06-22
Authors: Rachael Jinnette; Ai Narita; Byron Manning; Sarah A McNaughton; John C Mathers; Katherine M Livingstone Journal: Adv Nutr Date: 2021-06-01 Impact factor: 8.701
Authors: Keith A Grimaldi; Ben van Ommen; Jose M Ordovas; Laurence D Parnell; John C Mathers; Igor Bendik; Lorraine Brennan; Carlos Celis-Morales; Elisa Cirillo; Hannelore Daniel; Brenda de Kok; Ahmed El-Sohemy; Susan J Fairweather-Tait; Rosalind Fallaize; Michael Fenech; Lynnette R Ferguson; Eileen R Gibney; Mike Gibney; Ingrid M F Gjelstad; Jim Kaput; Anette S Karlsen; Silvia Kolossa; Julie Lovegrove; Anna L Macready; Cyril F M Marsaux; J Alfredo Martinez; Fermin Milagro; Santiago Navas-Carretero; Helen M Roche; Wim H M Saris; Iwona Traczyk; Henk van Kranen; Lars Verschuren; Fabio Virgili; Peter Weber; Jildau Bouwman Journal: Genes Nutr Date: 2017-12-15 Impact factor: 5.523
Authors: Rosalind Fallaize; Katherine M Livingstone; Carlos Celis-Morales; Anna L Macready; Rodrigo San-Cristobal; Santiago Navas-Carretero; Cyril F M Marsaux; Clare B O'Donovan; Silvia Kolossa; George Moschonis; Marianne C Walsh; Eileen R Gibney; Lorraine Brennan; Jildau Bouwman; Yannis Manios; Miroslaw Jarosz; J Alfredo Martinez; Hannelore Daniel; Wim H M Saris; Thomas E Gundersen; Christian A Drevon; Michael J Gibney; John C Mathers; Julie A Lovegrove Journal: Nutrients Date: 2018-01-06 Impact factor: 5.717
Authors: Katherine M Livingstone; Carlos Celis-Morales; Santiago Navas-Carretero; Rodrigo San-Cristobal; Hannah Forster; Clara Woolhead; Clare B O'Donovan; George Moschonis; Yannis Manios; Iwona Traczyk; Thomas E Gundersen; Christian A Drevon; Cyril F M Marsaux; Rosalind Fallaize; Anna L Macready; Hannelore Daniel; Wim H M Saris; Julie A Lovegrove; Mike Gibney; Eileen R Gibney; Marianne Walsh; Lorraine Brennan; J Alfredo Martinez; John C Mathers Journal: Int J Behav Nutr Phys Act Date: 2021-06-07 Impact factor: 6.457