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Literature DB >> 27350602

A plethora of pleiotropy across complex traits.

Abstract

A new analysis has identified hundreds of loci that are associated with multiple traits or diseases by comparing genome-wide association study (GWAS) data for 42 complex traits. The study uses the power of GWAS to provide evidence of pairs of traits with a likely causal relationship.

Mesh：

Year: 2016 PMID： 27350602 DOI： 10.1038/ng.3604

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

7 in total

1. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets.

Authors: Zhihong Zhu; Futao Zhang; Han Hu; Andrew Bakshi; Matthew R Robinson; Joseph E Powell; Grant W Montgomery; Michael E Goddard; Naomi R Wray; Peter M Visscher; Jian Yang
Journal: Nat Genet Date: 2016-03-28 Impact factor: 38.330

2. The Genotype-Tissue Expression (GTEx) project.

Authors:
Journal: Nat Genet Date: 2013-06 Impact factor: 38.330

Review 3. Pleiotropy in complex traits: challenges and strategies.

Authors: Nadia Solovieff; Chris Cotsapas; Phil H Lee; Shaun M Purcell; Jordan W Smoller
Journal: Nat Rev Genet Date: 2013-06-11 Impact factor: 53.242

4. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Authors: S Hong Lee; Stephan Ripke; Benjamin M Neale; Stephen V Faraone; Shaun M Purcell; Roy H Perlis; Bryan J Mowry; Anita Thapar; Michael E Goddard; John S Witte; Devin Absher; Ingrid Agartz; Huda Akil; Farooq Amin; Ole A Andreassen; Adebayo Anjorin; Richard Anney; Verneri Anttila; Dan E Arking; Philip Asherson; Maria H Azevedo; Lena Backlund; Judith A Badner; Anthony J Bailey; Tobias Banaschewski; Jack D Barchas; Michael R Barnes; Thomas B Barrett; Nicholas Bass; Agatino Battaglia; Michael Bauer; Mònica Bayés; Frank Bellivier; Sarah E Bergen; Wade Berrettini; Catalina Betancur; Thomas Bettecken; Joseph Biederman; Elisabeth B Binder; Donald W Black; Douglas H R Blackwood; Cinnamon S Bloss; Michael Boehnke; Dorret I Boomsma; Gerome Breen; René Breuer; Richard Bruggeman; Paul Cormican; Nancy G Buccola; Jan K Buitelaar; William E Bunney; Joseph D Buxbaum; William F Byerley; Enda M Byrne; Sian Caesar; Wiepke Cahn; Rita M Cantor; Miguel Casas; Aravinda Chakravarti; Kimberly Chambert; Khalid Choudhury; Sven Cichon; C Robert Cloninger; David A Collier; Edwin H Cook; Hilary Coon; Bru Cormand; Aiden Corvin; William H Coryell; David W Craig; Ian W Craig; Jennifer Crosbie; Michael L Cuccaro; David Curtis; Darina Czamara; Susmita Datta; Geraldine Dawson; Richard Day; Eco J De Geus; Franziska Degenhardt; Srdjan Djurovic; Gary J Donohoe; Alysa E Doyle; Jubao Duan; Frank Dudbridge; Eftichia Duketis; Richard P Ebstein; Howard J Edenberg; Josephine Elia; Sean Ennis; Bruno Etain; Ayman Fanous; Anne E Farmer; I Nicol Ferrier; Matthew Flickinger; Eric Fombonne; Tatiana Foroud; Josef Frank; Barbara Franke; Christine Fraser; Robert Freedman; Nelson B Freimer; Christine M Freitag; Marion Friedl; Louise Frisén; Louise Gallagher; Pablo V Gejman; Lyudmila Georgieva; Elliot S Gershon; Daniel H Geschwind; Ina Giegling; Michael Gill; Scott D Gordon; Katherine Gordon-Smith; Elaine K Green; Tiffany A Greenwood; Dorothy E Grice; Magdalena Gross; Detelina Grozeva; Weihua Guan; Hugh Gurling; Lieuwe De Haan; Jonathan L Haines; Hakon Hakonarson; Joachim Hallmayer; Steven P Hamilton; Marian L Hamshere; Thomas F Hansen; Annette M Hartmann; Martin Hautzinger; Andrew C Heath; Anjali K Henders; Stefan Herms; Ian B Hickie; Maria Hipolito; Susanne Hoefels; Peter A Holmans; Florian Holsboer; Witte J Hoogendijk; Jouke-Jan Hottenga; Christina M Hultman; Vanessa Hus; Andrés Ingason; Marcus Ising; Stéphane Jamain; Edward G Jones; Ian Jones; Lisa Jones; Jung-Ying Tzeng; Anna K Kähler; René S Kahn; Radhika Kandaswamy; Matthew C Keller; James L Kennedy; Elaine Kenny; Lindsey Kent; Yunjung Kim; George K Kirov; Sabine M Klauck; Lambertus Klei; James A Knowles; Martin A Kohli; Daniel L Koller; Bettina Konte; Ania Korszun; Lydia Krabbendam; Robert Krasucki; Jonna Kuntsi; Phoenix Kwan; Mikael Landén; Niklas Långström; Mark Lathrop; Jacob Lawrence; William B Lawson; Marion Leboyer; David H Ledbetter; Phil H Lee; Todd Lencz; Klaus-Peter Lesch; Douglas F Levinson; Cathryn M Lewis; Jun Li; Paul Lichtenstein; Jeffrey A Lieberman; Dan-Yu Lin; Don H Linszen; Chunyu Liu; Falk W Lohoff; Sandra K Loo; Catherine Lord; Jennifer K Lowe; Susanne Lucae; Donald J MacIntyre; Pamela A F Madden; Elena Maestrini; Patrik K E Magnusson; Pamela B Mahon; Wolfgang Maier; Anil K Malhotra; Shrikant M Mane; Christa L Martin; Nicholas G Martin; Manuel Mattheisen; Keith Matthews; Morten Mattingsdal; Steven A McCarroll; Kevin A McGhee; James J McGough; Patrick J McGrath; Peter McGuffin; Melvin G McInnis; Andrew McIntosh; Rebecca McKinney; Alan W McLean; Francis J McMahon; William M McMahon; Andrew McQuillin; Helena Medeiros; Sarah E Medland; Sandra Meier; Ingrid Melle; Fan Meng; Jobst Meyer; Christel M Middeldorp; Lefkos Middleton; Vihra Milanova; Ana Miranda; Anthony P Monaco; Grant W Montgomery; Jennifer L Moran; Daniel Moreno-De-Luca; Gunnar Morken; Derek W Morris; Eric M Morrow; Valentina Moskvina; Pierandrea Muglia; Thomas W Mühleisen; Walter J Muir; Bertram Müller-Myhsok; Michael Murtha; Richard M Myers; Inez Myin-Germeys; Michael C Neale; Stan F Nelson; Caroline M Nievergelt; Ivan Nikolov; Vishwajit Nimgaonkar; Willem A Nolen; Markus M Nöthen; John I Nurnberger; Evaristus A Nwulia; Dale R Nyholt; Colm O'Dushlaine; Robert D Oades; Ann Olincy; Guiomar Oliveira; Line Olsen; Roel A Ophoff; Urban Osby; Michael J Owen; Aarno Palotie; Jeremy R Parr; Andrew D Paterson; Carlos N Pato; Michele T Pato; Brenda W Penninx; Michele L Pergadia; Margaret A Pericak-Vance; Benjamin S Pickard; Jonathan Pimm; Joseph Piven; Danielle Posthuma; James B Potash; Fritz Poustka; Peter Propping; Vinay Puri; Digby J Quested; Emma M Quinn; Josep Antoni Ramos-Quiroga; Henrik B Rasmussen; Soumya Raychaudhuri; Karola Rehnström; Andreas Reif; Marta Ribasés; John P Rice; Marcella Rietschel; Kathryn Roeder; Herbert Roeyers; Lizzy Rossin; Aribert Rothenberger; Guy Rouleau; Douglas Ruderfer; Dan Rujescu; Alan R Sanders; Stephan J Sanders; Susan L Santangelo; Joseph A Sergeant; Russell Schachar; Martin Schalling; Alan F Schatzberg; William A Scheftner; Gerard D Schellenberg; Stephen W Scherer; Nicholas J Schork; Thomas G Schulze; Johannes Schumacher; Markus Schwarz; Edward Scolnick; Laura J Scott; Jianxin Shi; Paul D Shilling; Stanley I Shyn; Jeremy M Silverman; Susan L Slager; Susan L Smalley; Johannes H Smit; Erin N Smith; Edmund J S Sonuga-Barke; David St Clair; Matthew State; Michael Steffens; Hans-Christoph Steinhausen; John S Strauss; Jana Strohmaier; T Scott Stroup; James S Sutcliffe; Peter Szatmari; Szabocls Szelinger; Srinivasa Thirumalai; Robert C Thompson; Alexandre A Todorov; Federica Tozzi; Jens Treutlein; Manfred Uhr; Edwin J C G van den Oord; Gerard Van Grootheest; Jim Van Os; Astrid M Vicente; Veronica J Vieland; John B Vincent; Peter M Visscher; Christopher A Walsh; Thomas H Wassink; Stanley J Watson; Myrna M Weissman; Thomas Werge; Thomas F Wienker; Ellen M Wijsman; Gonneke Willemsen; Nigel Williams; A Jeremy Willsey; Stephanie H Witt; Wei Xu; Allan H Young; Timothy W Yu; Stanley Zammit; Peter P Zandi; Peng Zhang; Frans G Zitman; Sebastian Zöllner; Bernie Devlin; John R Kelsoe; Pamela Sklar; Mark J Daly; Michael C O'Donovan; Nicholas Craddock; Patrick F Sullivan; Jordan W Smoller; Kenneth S Kendler; Naomi R Wray
Journal: Nat Genet Date: 2013-08-11 Impact factor: 38.330

5. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

Authors: Jacqueline K White; Anna-Karin Gerdin; Natasha A Karp; Ed Ryder; Marija Buljan; James N Bussell; Jennifer Salisbury; Simon Clare; Neil J Ingham; Christine Podrini; Richard Houghton; Jeanne Estabel; Joanna R Bottomley; David G Melvin; David Sunter; Niels C Adams; David Tannahill; Darren W Logan; Daniel G Macarthur; Jonathan Flint; Vinit B Mahajan; Stephen H Tsang; Ian Smyth; Fiona M Watt; William C Skarnes; Gordon Dougan; David J Adams; Ramiro Ramirez-Solis; Allan Bradley; Karen P Steel
Journal: Cell Date: 2013-07-18 Impact factor: 41.582

6. An atlas of genetic correlations across human diseases and traits.

Authors: Brendan Bulik-Sullivan; Hilary K Finucane; Verneri Anttila; Alexander Gusev; Felix R Day; Po-Ru Loh; Laramie Duncan; John R B Perry; Nick Patterson; Elise B Robinson; Mark J Daly; Alkes L Price; Benjamin M Neale
Journal: Nat Genet Date: 2015-09-28 Impact factor: 38.330

7. Detection and interpretation of shared genetic influences on 42 human traits.

Authors: Joseph K Pickrell; Tomaz Berisa; Jimmy Z Liu; Laure Ségurel; Joyce Y Tung; David A Hinds
Journal: Nat Genet Date: 2016-05-16 Impact factor: 38.330

7 in total

47 in total

1. Genetic Basis of Maize Resistance to Multiple Insect Pests: Integrated Genome-Wide Comparative Mapping and Candidate Gene Prioritization.

Authors: A Badji; D B Kwemoi; L Machida; D Okii; N Mwila; S Agbahoungba; F Kumi; A Ibanda; A Bararyenya; M Solemanegy; T Odong; P Wasswa; M Otim; G Asea; M Ochwo-Ssemakula; H Talwana; S Kyamanywa; P Rubaihayo
Journal: Genes (Basel) Date: 2020-06-24 Impact factor: 4.096

2. Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation.

Authors: Grant Kinsler; Kerry Geiler-Samerotte; Dmitri A Petrov
Journal: Elife Date: 2020-12-02 Impact factor: 8.140

Review 3. High-throughput mouse phenomics for characterizing mammalian gene function.

Authors: Steve D M Brown; Chris C Holmes; Ann-Marie Mallon; Terrence F Meehan; Damian Smedley; Sara Wells
Journal: Nat Rev Genet Date: 2018-06 Impact factor: 53.242

4. Extending Causality Tests with Genetic Instruments: An Integration of Mendelian Randomization with the Classical Twin Design.

Authors: Camelia C Minică; Conor V Dolan; Dorret I Boomsma; Eco de Geus; Michael C Neale
Journal: Behav Genet Date: 2018-06-07 Impact factor: 2.805

A plethora of pleiotropy across complex traits.

1. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets.

2. The Genotype-Tissue Expression (GTEx) project.

Review 3. Pleiotropy in complex traits: challenges and strategies.

4. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

5. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

6. An atlas of genetic correlations across human diseases and traits.

7. Detection and interpretation of shared genetic influences on 42 human traits.

1. Genetic Basis of Maize Resistance to Multiple Insect Pests: Integrated Genome-Wide Comparative Mapping and Candidate Gene Prioritization.

2. Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation.

Review 3. High-throughput mouse phenomics for characterizing mammalian gene function.

4. Extending Causality Tests with Genetic Instruments: An Integration of Mendelian Randomization with the Classical Twin Design.

5. Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.

6. PleioNet: a web-based visualization tool for exploring pleiotropy across complex traits.

7. A multitrait GWAS sheds light on insulin resistance.

Review 8. Microbial genome-wide association studies: lessons from human GWAS.

9. Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.

Review 10. An Expanded View of Complex Traits: From Polygenic to Omnigenic.