Literature DB >> 27335694

A novel device to create consistent deep dermal burns in a porcine model.

Seema Menon1, Queenie Chan2, Monique Bertinetti2, John G Harvey1, Erik R La Hei2, Andrew Ja Holland1.   

Abstract

We conducted this study to evaluate a novel device to create a consistent and reproducible deep partial thickness burn in a porcine model. A thermostatically controlled, heated aluminium disc device was fashioned by the Biomedical Department of our institution. Contact burns were made on the flank of two Great White pigs by applying the device heated to 92°C at intervals of 5, 10, 15 and 20 seconds to four separate test areas area of skin. Biopsies for histological analysis of burn depth were taken on day 0 at 10 minutes post burn and on day 8. Biopsies taken at day 0 revealed superficial to mid-dermal burns, with minimal dermal edema and necrosis. Those from day 8 showed mid to deep dermal edema and necrosis in all four test areas following a 20 second contact duration burn. The new contact burn device was able to create a consistent deep dermal burn after 20 seconds of contact. We anticipate that this new device could be used to investigate the development of hypertrophic scarring in a porcine model.

Entities:  

Keywords:  Contact burn; partial thickness; porcine model

Year:  2016        PMID: 27335694      PMCID: PMC4913230     

Source DB:  PubMed          Journal:  Int J Burns Trauma        ISSN: 2160-2026


  8 in total

Review 1.  The pig as a model for human wound healing.

Authors:  T P Sullivan; W H Eaglstein; S C Davis; P Mertz
Journal:  Wound Repair Regen       Date:  2001 Mar-Apr       Impact factor: 3.617

2.  The correlation between time to skin grafting and hypertrophic scarring following an acute contact burn in a porcine model.

Authors:  Queenie E Chan; John G Harvey; Nicole S Graf; Craig Godfrey; Andrew J A Holland
Journal:  J Burn Care Res       Date:  2012 Mar-Apr       Impact factor: 1.845

3.  A porcine deep dermal partial thickness burn model with hypertrophic scarring.

Authors:  Leila Cuttle; Margit Kempf; Gael E Phillips; Julie Mill; Mark T Hayes; John F Fraser; Xue-Qing Wang; Roy M Kimble
Journal:  Burns       Date:  2006-08-01       Impact factor: 2.744

4.  Evidence for the link between healing time and the development of hypertrophic scars (HTS) in paediatric burns due to scald injury.

Authors:  Tania C S Cubison; Sarah A Pape; Nicholas Parkhouse
Journal:  Burns       Date:  2006-08-08       Impact factor: 2.744

5.  Cooling the burn wound: evaluation of different modalites.

Authors:  V Jandera; D A Hudson; P M de Wet; P M Innes; H Rode
Journal:  Burns       Date:  2000-05       Impact factor: 2.744

6.  Scaling of respiratory variables in mammals.

Authors:  W R Stahl
Journal:  J Appl Physiol       Date:  1967-03       Impact factor: 3.531

7.  Hypertrophic burn scars: analysis of variables.

Authors:  E A Deitch; T M Wheelahan; M P Rose; J Clothier; J Cotter
Journal:  J Trauma       Date:  1983-10

8.  Conservative surgical debridement as a burn treatment: supporting evidence from a porcine burn model.

Authors:  Xue-Qing Wang; Margit Kempf; Pei-Yun Liu; Leila Cuttle; Hong-En Chang; Olena Kravchuk; Julie Mill; Gael E Phillips; Roy M Kimble
Journal:  Wound Repair Regen       Date:  2008 Nov-Dec       Impact factor: 3.617

  8 in total
  1 in total

Review 1.  Comparing the reported burn conditions for different severity burns in porcine models: a systematic review.

Authors:  Christine J Andrews; Leila Cuttle
Journal:  Int Wound J       Date:  2017-07-23       Impact factor: 3.315

  1 in total

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