| Literature DB >> 27335694 |
Seema Menon1, Queenie Chan2, Monique Bertinetti2, John G Harvey1, Erik R La Hei2, Andrew Ja Holland1.
Abstract
We conducted this study to evaluate a novel device to create a consistent and reproducible deep partial thickness burn in a porcine model. A thermostatically controlled, heated aluminium disc device was fashioned by the Biomedical Department of our institution. Contact burns were made on the flank of two Great White pigs by applying the device heated to 92°C at intervals of 5, 10, 15 and 20 seconds to four separate test areas area of skin. Biopsies for histological analysis of burn depth were taken on day 0 at 10 minutes post burn and on day 8. Biopsies taken at day 0 revealed superficial to mid-dermal burns, with minimal dermal edema and necrosis. Those from day 8 showed mid to deep dermal edema and necrosis in all four test areas following a 20 second contact duration burn. The new contact burn device was able to create a consistent deep dermal burn after 20 seconds of contact. We anticipate that this new device could be used to investigate the development of hypertrophic scarring in a porcine model.Entities:
Keywords: Contact burn; partial thickness; porcine model
Year: 2016 PMID: 27335694 PMCID: PMC4913230
Source DB: PubMed Journal: Int J Burns Trauma ISSN: 2160-2026