Literature DB >> 10741593

Cooling the burn wound: evaluation of different modalites.

V Jandera1, D A Hudson, P M de Wet, P M Innes, H Rode.   

Abstract

A study was undertaken to investigate the cooling and healing effect of different modalities: Melaleuca Alternifolia Hydrogel (Levtrade International (Pty) Ltd.) was compared with tap water as a coolant following application onto a fresh deep partial thickness hot water burn in a porcine model. Four identical circular scalds were created on the backs of 10 pigs. One wound was not treated and served as a control. The other 3 wounds were either cooled with tap water (15 degrees C) or had Melaleuca Hydrogel dressing applied immediately, or after a 30 min delay. Intradermal temperatures were monitored in all wounds: preburn, during the burn and at regular intervals for 1 h. The wounds were biopsied for histological assessment. These samples were repeated at 24 h and 3 weeks. The mean decrease in final temperature at 1 h was in comparison to the preburn temperature; control +0.44 degrees C (i.e. a temperature increase); water -7.82 degrees C; Melaleuca Hydrogel -3.87 degrees C; Melaleuca Hydrogel after 30 min delay -2.67 degrees C. Clinical and histological assessment at 21 days indicated more rapid healing in both the Melaleuca Hydrogel and water-cooled burns compared with the untreated controls. Effective cooling of the burn wound and an increased rate of wound healing was achieved by both repeated tap water compresses and by immediate or delayed application of Melaleuca Hydrogel. Cooling is an effective means to reduce tissue damage and increase wound healing.

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Year:  2000        PMID: 10741593     DOI: 10.1016/s0305-4179(99)00133-3

Source DB:  PubMed          Journal:  Burns        ISSN: 0305-4179            Impact factor:   2.744


  16 in total

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Authors:  T J Coats; C Edwards; R Newton; E Staun
Journal:  Emerg Med J       Date:  2002-05       Impact factor: 2.740

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Review 3.  The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting: a systematic review of the literature.

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Journal:  Int Wound J       Date:  2015-07-15       Impact factor: 3.315

Review 4.  Comparing the reported burn conditions for different severity burns in porcine models: a systematic review.

Authors:  Christine J Andrews; Leila Cuttle
Journal:  Int Wound J       Date:  2017-07-23       Impact factor: 3.315

5.  Limb cooling with targeted arterial infusion of cold fluid alleviates scald injury: an experimental rabbit study.

Authors:  Hao Guan; Zhijing Zhao; Qin Zhou; Fei He; Min Yu; Weixia Cai; Ximing Yang; Zhigang Xu; Hongyi Hou; Dahai Hu
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Review 6.  Consensus on the prehospital approach to burns patient management.

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Review 7.  [Rational treatment of first-degree burns].

Authors:  E Proksch; J-M Jensen; A Crichton-Smith; A Fowler; J Clitherow
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8.  A novel device to create consistent deep dermal burns in a porcine model.

Authors:  Seema Menon; Queenie Chan; Monique Bertinetti; John G Harvey; Erik R La Hei; Andrew Ja Holland
Journal:  Int J Burns Trauma       Date:  2016-06-01

9.  No evidence for the development of acute analgesic tolerance during and hyperalgesia after prolonged remifentanil administration in mice.

Authors:  Hideaki Ishii; Andrey B Petrenko; Tatsuro Kohno; Hiroshi Baba
Journal:  Mol Pain       Date:  2013-03-07       Impact factor: 3.395

10.  The influence of operating parameters on the drug release and antibacterial performances of alginate fibrous dressings prepared by wet spinning.

Authors:  Hsin-Yi Lin; Hsin-Wei Wang
Journal:  Biomatter       Date:  2012 Oct-Dec
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