Literature DB >> 27334122

Did a then unknown virus, HHV-6/7, give rise to the whooping cough vaccine controversy of the 1970s?

Philip P Mortimer1.   

Abstract

During the 1970s there was a gross loss of public confidence in infant diphtheria-tetanus-pertussis (DTP) vaccination in the UK. As well as febrile reactions and convulsions, permanent neurological damage was ascribed to the pertussis component of the vaccine, and those concerns resonated worldwide. The subsequent recognition of human herpes virus 6 (HHV-6) and 7 (HHV-7) as common sources of fever in infancy suggests that they were the main underlying cause of what was reported as DTP constitutional side-effects. With more precise data on the incidence of HHV-6/7 and other virus infections in early life it would be possible to model the concurrence of viral illnesses with routine immunizations. Adventitious viral infections may be the cause of side-effects ascribed to the numerous childhood immunizations now being given.

Entities:  

Keywords:  DTP vaccine; HHV-6/7; modelling; side-effects

Mesh:

Substances:

Year:  2016        PMID: 27334122      PMCID: PMC9150420          DOI: 10.1017/S0950268816001060

Source DB:  PubMed          Journal:  Epidemiol Infect        ISSN: 0950-2688            Impact factor:   4.434


  16 in total

1.  Impact of anti-vaccine movements on pertussis control: the untold story.

Authors:  E J Gangarosa; A M Galazka; C R Wolfe; L M Phillips; R E Gangarosa; E Miller; R T Chen
Journal:  Lancet       Date:  1998-01-31       Impact factor: 79.321

2.  Retraction--Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.

Authors: 
Journal:  Lancet       Date:  2010-02-06       Impact factor: 79.321

Review 3.  The acellular pertussis vaccine trials: an interpretation.

Authors:  S A Plotkin; M Cadoz
Journal:  Pediatr Infect Dis J       Date:  1997-05       Impact factor: 2.129

4.  Pertussis immunisation and serious acute neurological illnesses in children.

Authors:  D Miller; N Madge; J Diamond; J Wadsworth; E Ross
Journal:  BMJ       Date:  1993-11-06

5.  Symptoms after primary immunisation with DTP and with DT vaccine.

Authors:  T M Pollock; E Miller; J Y Mortimer; G Smith
Journal:  Lancet       Date:  1984-07-21       Impact factor: 79.321

6.  Primary human herpesvirus-6 infection is frequently overlooked as a cause of febrile fits in young children.

Authors:  K N Ward; J J Gray
Journal:  J Med Virol       Date:  1994-02       Impact factor: 2.327

7.  Pertussis immunisation and serious acute neurological illness in children.

Authors:  D L Miller; E M Ross; R Alderslade; M H Bellman; N S Rawson
Journal:  Br Med J (Clin Res Ed)       Date:  1981-05-16

8.  Nature and rates of adverse reactions associated with DTP and DT immunizations in infants and children.

Authors:  C L Cody; L J Baraff; J D Cherry; S M Marcy; C R Manclark
Journal:  Pediatrics       Date:  1981-11       Impact factor: 7.124

9.  Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children.

Authors:  Katja C Wolthers; Kimberley S M Benschop; Janke Schinkel; Richard Molenkamp; Rosemarijn M Bergevoet; Ingrid J B Spijkerman; H Carlijn Kraakman; Dasja Pajkrt
Journal:  Clin Infect Dis       Date:  2008-08-01       Impact factor: 9.079

10.  Human papillomavirus vaccination coverage among adolescents, 2007-2013, and postlicensure vaccine safety monitoring, 2006-2014--United States.

Authors:  Shannon Stokley; Jenny Jeyarajah; David Yankey; Maria Cano; Julianne Gee; Jill Roark; Robinette C Curtis; Lauri Markowitz
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2014-07-25       Impact factor: 17.586

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