| Literature DB >> 27329760 |
Liping Hou1, Sarah E Bergen2,3, Nirmala Akula1, Jie Song2, Christina M Hultman2, Mikael Landén4,2, Mazda Adli5, Martin Alda6, Raffaella Ardau7, Bárbara Arias8, Jean-Michel Aubry9, Lena Backlund10, Judith A Badner11, Thomas B Barrett12, Michael Bauer13, Bernhard T Baune14, Frank Bellivier15, Antonio Benabarre16, Susanne Bengesser17, Wade H Berrettini18, Abesh Kumar Bhattacharjee19, Joanna M Biernacka20,21, Armin Birner17, Cinnamon S Bloss22, Clara Brichant-Petitjean15, Elise T Bui1, William Byerley23, Pablo Cervantes24, Caterina Chillotti7, Sven Cichon25,26,27,28, Francesc Colom16, William Coryell29, David W Craig30, Cristiana Cruceanu31, Piotr M Czerski32, Tony Davis14, Alexandre Dayer9, Franziska Degenhardt25,26, Maria Del Zompo33, J Raymond DePaulo34, Howard J Edenberg35, Bruno Étain36, Peter Falkai37, Tatiana Foroud38, Andreas J Forstner25,26, Louise Frisén39,40, Mark A Frye21, Janice M Fullerton41,42, Sébastien Gard43, Julie S Garnham6, Elliot S Gershon11, Fernando S Goes34, Tiffany A Greenwood19, Maria Grigoroiu-Serbanescu44, Joanna Hauser32, Urs Heilbronner45,46, Stefanie Heilmann-Heimbach25,26, Stefan Herms25,26,28, Maria Hipolito47, Shashi Hitturlingappa14, Per Hoffmann25,26,27,28, Andrea Hofmann25,26, Stephane Jamain36, Esther Jiménez16, Jean-Pierre Kahn48, Layla Kassem1, John R Kelsoe19, Sarah Kittel-Schneider49, Sebastian Kliwicki50, Daniel L Koller38, Barbara König51, Nina Lackner17, Gonzalo Laje1, Maren Lang52, Catharina Lavebratt10, William B Lawson47, Marion Leboyer36, Susan G Leckband53, Chunyu Liu54, Anna Maaser25,26, Pamela B Mahon34, Wolfgang Maier55, Mario Maj56, Mirko Manchia33,57, Lina Martinsson39, Michael J McCarthy58, Susan L McElroy59, Melvin G McInnis60, Rebecca McKinney19, Philip B Mitchell61, Marina Mitjans8, Francis M Mondimore34, Palmiero Monteleone56,62, Thomas W Mühleisen25,26,27, Caroline M Nievergelt19, Markus M Nöthen25,26, Tomas Novák63, John I Nurnberger64, Evaristus A Nwulia47, Urban Ösby65, Andrea Pfennig13, James B Potash66, Peter Propping25, Andreas Reif49, Eva Reininghaus17, John Rice67, Marcella Rietschel52, Guy A Rouleau68, Janusz K Rybakowski50, Martin Schalling10, William A Scheftner69, Peter R Schofield42,70, Nicholas J Schork22, Thomas G Schulze1,34,45,46,52, Johannes Schumacher25,26, Barbara W Schweizer34, Giovanni Severino33, Tatyana Shekhtman19, Paul D Shilling19, Christian Simhandl71, Claire M Slaney6, Erin N Smith22, Alessio Squassina33, Thomas Stamm5, Pavla Stopkova63, Fabian Streit52, Jana Strohmaier52, Szabolcs Szelinger30, Sarah K Tighe66, Alfonso Tortorella56, Gustavo Turecki31, Eduard Vieta16, Julia Volkert49, Stephanie H Witt52, Adam Wright61, Peter P Zandi72, Peng Zhang60, Sebastian Zollner60, Francis J McMahon73.
Abstract
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P = 5.87 × 10 - 9; odds ratio (OR) = 1.12) and markers within ERBB2 (rs2517959, P = 4.53 × 10 - 9; OR = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS. Published by Oxford University Press 2016. This work is written by US Government employees and is in the public domain in the United States.Entities:
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Year: 2016 PMID： 27329760 PMCID： PMC5179929 DOI： 10.1093/hmg/ddw181
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150