Azmeraw T Amare1, Klaus Oliver Schubert1,2, Liping Hou3, Scott R Clark1, Sergi Papiol4,5, Urs Heilbronner4,6, Franziska Degenhardt7, Fasil Tekola-Ayele8, Yi-Hsiang Hsu9,10,11, Tatyana Shekhtman12, Mazda Adli13, Nirmala Akula3, Kazufumi Akiyama14, Raffaella Ardau15, Bárbara Arias16, Jean-Michel Aubry17, Lena Backlund18, Abesh Kumar Bhattacharjee12, Frank Bellivier19, Antonio Benabarre20, Susanne Bengesser21, Joanna M Biernacka22,23, Armin Birner21, Clara Brichant-Petitjean19, Pablo Cervantes24, Hsi-Chung Chen25, Caterina Chillotti15, Sven Cichon7,26, Cristiana Cruceanu27, Piotr M Czerski28, Nina Dalkner21, Alexandre Dayer17, Maria Del Zompo29, J Raymond DePaulo30, Bruno Étain19, Peter Falkai5, Andreas J Forstner7,26,31, Louise Frisen18, Mark A Frye23, Janice M Fullerton32,33, Sébastien Gard34, Julie S Garnham35, Fernando S Goes30, Maria Grigoroiu-Serbanescu36, Paul Grof37, Ryota Hashimoto38,39, Joanna Hauser28, Stefan Herms7,26, Per Hoffmann7,26, Andrea Hofmann7, Stephane Jamain40, Esther Jiménez20, Jean-Pierre Kahn41, Layla Kassem3, Po-Hsiu Kuo42, Tadafumi Kato43, John Kelsoe12, Sarah Kittel-Schneider44, Sebastian Kliwicki45, Barbara König46, Ichiro Kusumi47, Gonzalo Laje3, Mikael Landén48,49, Catharina Lavebratt18, Marion Leboyer50, Susan G Leckband51, Alfonso Tortorella52, Mirko Manchia53,54, Lina Martinsson55, Michael J McCarthy12,56, Susan McElroy57, Francesc Colom20,58, Marina Mitjans59,60, Francis M Mondimore30, Palmiero Monteleone61,62, Caroline M Nievergelt12, Markus M Nöthen7, Tomas Novák63, Claire O'Donovan35, Norio Ozaki64, Urban Ösby65, Andrea Pfennig66, James B Potash30, Andreas Reif43, Eva Reininghaus21, Guy A Rouleau67, Janusz K Rybakowski44, Martin Schalling18, Peter R Schofield32,33, Barbara W Schweizer30, Giovanni Severino29, Paul D Shilling18, Katzutaka Shimoda68, Christian Simhandl69, Claire M Slaney35, Alessio Squassina29, Thomas Stamm13, Pavla Stopkova63, Mario Maj62, Gustavo Turecki27, Eduard Vieta20, Julia Volkert44, Stephanie Witt70, Adam Wright71, Peter P Zandi72, Philip B Mitchell71, Michael Bauer66, Martin Alda35, Marcella Rietschel70, Francis J McMahon3, Thomas G Schulze3,4,6,30,70, Bernhard T Baune1. 1. Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia. 2. Northern Adelaide Local Health Network, Mental Health Services, Adelaide, South Australia, Australia. 3. Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland. 4. Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig-Maximilian University of Munich, Munich, Germany. 5. Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University of Munich, Munich, Germany. 6. Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University Göttingen, Göttingen, Germany. 7. Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. 8. Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. 9. Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, Massachusetts. 10. Program for Quantitative Genomics, Harvard School of Public Health, Boston, Massachusetts. 11. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts. 12. Department of Psychiatry, University of California San Diego. 13. Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany. 14. Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan. 15. Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy. 16. Unitat de Zoologia i Antropologia Biològica (Dpt Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina, University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain. 17. Department of Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland. 18. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. 19. Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France. 20. Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain. 21. Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria. 22. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. 23. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota. 24. The Neuromodulation Unit, McGill University Health Centre, Montreal, Canada. 25. Department of Psychiatry and Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan. 26. Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland. 27. Douglas Mental Health University Institute, McGill University, Montreal, Canada. 28. Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland. 29. Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. 30. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland. 31. Department of Psychiatry, University of Basel, Basel, Switzerland. 32. Neuroscience Research Australia, Sydney, New South Wales, Australia. 33. School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia. 34. Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France. 35. Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada. 36. Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania. 37. Mood Disorders Center of Ottawa, Ontario, Canada. 38. Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan. 39. Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan. 40. Institut National de la Santé et de la Recherche Médicale Unité 955, Psychiatrie Translationnelle, Créteil, France. 41. Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy, Université de Lorraine, Nancy, France. 42. Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. 43. Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan. 44. Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany. 45. Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. 46. Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria. 47. Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 48. Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden. 49. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 50. Inserm U955, Translational Psychiatry Laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France. 51. Department of Pharmacy, Veterans Affairs San Diego Healthcare System, San Diego, California. 52. Department of Psychiatry, University of Perugia, Perugia, Italy. 53. Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy. 54. Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada. 55. Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden. 56. Department of Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, California. 57. Department of Psychiatry, Lindner Center of Hope and University of Cincinnati, Mason, Ohio. 58. Mental Health Research Group, IMIM-Hospital del Mar, Barcelona, Catalonia, Spain. 59. Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain. 60. Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany. 61. Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy. 62. Department of Psychiatry, Second University of Naples, Naples, Italy. 63. National Institute of Mental Health, Klecany, Czech Republic. 64. Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. 65. Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. 66. Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany. 67. Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada. 68. Department of Psychiatry, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. 69. Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria. 70. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 71. School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, New South Wales, Australia. 72. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Abstract
Importance: Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ). Objectives: To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association. Design, Setting, and Participants: A total of 2586 patients with BPAD who had undergone lithium treatment were genotyped and assessed for long-term response to treatment between 2008 and 2013. Weighted SCZ polygenic scores were computed at different P value thresholds using summary statistics from an international multicenter genome-wide association study (GWAS) of 36 989 individuals with SCZ and genotype data from patients with BPAD from the Consortium on Lithium Genetics. For functional exploration, a cross-trait meta-GWAS and pathway analysis was performed, combining GWAS summary statistics on SCZ and response to treatment with lithium. Data analysis was performed from September 2016 to February 2017. Main Outcomes and Measures: Treatment response to lithium was defined on both the categorical and continuous scales using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. The effect measures include odds ratios and the proportion of variance explained. Results: Of the 2586 patients in the study (mean [SD] age, 47.2 [13.9] years), 1478 were women and 1108 were men. The polygenic score for SCZ was inversely associated with lithium treatment response in the categorical outcome, at a threshold P < 5 × 10-2. Patients with BPAD who had a low polygenic load forSCZ responded better to lithium, with odds ratios for lithium response ranging from 3.46 (95% CI, 1.42-8.41) at the first decile to 2.03 (95% CI, 0.86-4.81) at the ninth decile, compared with the patients in the 10th decile of SCZ risk. In the cross-trait meta-GWAS, 15 genetic loci that may have overlapping effects on lithium treatment response and susceptibility to SCZ were identified. Functional pathway and network analysis of these loci point to the HLA antigen complex and inflammatory cytokines. Conclusions and Relevance: This study provides evidence for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD. These results suggest the potential for translational research aimed at personalized prescribing of lithium.
RCT Entities:
Importance: Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ). Objectives: To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association. Design, Setting, and Participants: A total of 2586 patients with BPAD who had undergone lithium treatment were genotyped and assessed for long-term response to treatment between 2008 and 2013. Weighted SCZ polygenic scores were computed at different P value thresholds using summary statistics from an international multicenter genome-wide association study (GWAS) of 36 989 individuals with SCZ and genotype data from patients with BPAD from the Consortium on Lithium Genetics. For functional exploration, a cross-trait meta-GWAS and pathway analysis was performed, combining GWAS summary statistics on SCZ and response to treatment with lithium. Data analysis was performed from September 2016 to February 2017. Main Outcomes and Measures: Treatment response to lithium was defined on both the categorical and continuous scales using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. The effect measures include odds ratios and the proportion of variance explained. Results: Of the 2586 patients in the study (mean [SD] age, 47.2 [13.9] years), 1478 were women and 1108 were men. The polygenic score for SCZ was inversely associated with lithium treatment response in the categorical outcome, at a threshold P < 5 × 10-2. Patients with BPAD who had a low polygenic load for SCZ responded better to lithium, with odds ratios for lithium response ranging from 3.46 (95% CI, 1.42-8.41) at the first decile to 2.03 (95% CI, 0.86-4.81) at the ninth decile, compared with the patients in the 10th decile of SCZ risk. In the cross-trait meta-GWAS, 15 genetic loci that may have overlapping effects on lithium treatment response and susceptibility to SCZ were identified. Functional pathway and network analysis of these loci point to the HLA antigen complex and inflammatory cytokines. Conclusions and Relevance: This study provides evidence for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD. These results suggest the potential for translational research aimed at personalized prescribing of lithium.
Authors: Heike Weber; Sarah Kittel-Schneider; Alexandra Gessner; Katharina Domschke; Maria Neuner; Christian P Jacob; Henriette N Buttenschon; Andrea Boreatti-Hümmer; Julia Volkert; Sabine Herterich; Bernhard T Baune; Silke Gross-Lesch; Juliane Kopf; Susanne Kreiker; Thuy Trang Nguyen; Lena Weissflog; Volker Arolt; Ole Mors; Jürgen Deckert; Klaus-Peter Lesch; Andreas Reif Journal: Neuropsychopharmacology Date: 2011-06-08 Impact factor: 7.853
Authors: Lakshmi N Yatham; Sidney H Kennedy; Sagar V Parikh; Ayal Schaffer; Serge Beaulieu; Martin Alda; Claire O'Donovan; Glenda Macqueen; Roger S McIntyre; Verinder Sharma; Arun Ravindran; L Trevor Young; Roumen Milev; David J Bond; Benicio N Frey; Benjamin I Goldstein; Beny Lafer; Boris Birmaher; Kyooseob Ha; Willem A Nolen; Michael Berk Journal: Bipolar Disord Date: 2012-12-12 Impact factor: 6.744
Authors: S Hong Lee; Stephan Ripke; Benjamin M Neale; Stephen V Faraone; Shaun M Purcell; Roy H Perlis; Bryan J Mowry; Anita Thapar; Michael E Goddard; John S Witte; Devin Absher; Ingrid Agartz; Huda Akil; Farooq Amin; Ole A Andreassen; Adebayo Anjorin; Richard Anney; Verneri Anttila; Dan E Arking; Philip Asherson; Maria H Azevedo; Lena Backlund; Judith A Badner; Anthony J Bailey; Tobias Banaschewski; Jack D Barchas; Michael R Barnes; Thomas B Barrett; Nicholas Bass; Agatino Battaglia; Michael Bauer; Mònica Bayés; Frank Bellivier; Sarah E Bergen; Wade Berrettini; Catalina Betancur; Thomas Bettecken; Joseph Biederman; Elisabeth B Binder; Donald W Black; Douglas H R Blackwood; Cinnamon S Bloss; Michael Boehnke; Dorret I Boomsma; Gerome Breen; René Breuer; Richard Bruggeman; Paul Cormican; Nancy G Buccola; Jan K Buitelaar; William E Bunney; Joseph D Buxbaum; William F Byerley; Enda M Byrne; Sian Caesar; Wiepke Cahn; Rita M Cantor; Miguel Casas; Aravinda Chakravarti; Kimberly Chambert; Khalid Choudhury; Sven Cichon; C Robert Cloninger; David A Collier; Edwin H Cook; Hilary Coon; Bru Cormand; Aiden Corvin; William H Coryell; David W Craig; Ian W Craig; Jennifer Crosbie; Michael L Cuccaro; David Curtis; Darina Czamara; Susmita Datta; Geraldine Dawson; Richard Day; Eco J De Geus; Franziska Degenhardt; Srdjan Djurovic; Gary J Donohoe; Alysa E Doyle; Jubao Duan; Frank Dudbridge; Eftichia Duketis; Richard P Ebstein; Howard J Edenberg; Josephine Elia; Sean Ennis; Bruno Etain; Ayman Fanous; Anne E Farmer; I Nicol Ferrier; Matthew Flickinger; Eric Fombonne; Tatiana Foroud; Josef Frank; Barbara Franke; Christine Fraser; Robert Freedman; Nelson B Freimer; Christine M Freitag; Marion Friedl; Louise Frisén; Louise Gallagher; Pablo V Gejman; Lyudmila Georgieva; Elliot S Gershon; Daniel H Geschwind; Ina Giegling; Michael Gill; Scott D Gordon; Katherine Gordon-Smith; Elaine K Green; Tiffany A Greenwood; Dorothy E Grice; Magdalena Gross; Detelina Grozeva; Weihua Guan; Hugh Gurling; Lieuwe De Haan; Jonathan L Haines; Hakon Hakonarson; Joachim Hallmayer; Steven P Hamilton; Marian L Hamshere; Thomas F Hansen; Annette M Hartmann; Martin Hautzinger; Andrew C Heath; Anjali K Henders; Stefan Herms; Ian B Hickie; Maria Hipolito; Susanne Hoefels; Peter A Holmans; Florian Holsboer; Witte J Hoogendijk; Jouke-Jan Hottenga; Christina M Hultman; Vanessa Hus; Andrés Ingason; Marcus Ising; Stéphane Jamain; Edward G Jones; Ian Jones; Lisa Jones; Jung-Ying Tzeng; Anna K Kähler; René S Kahn; Radhika Kandaswamy; Matthew C Keller; James L Kennedy; Elaine Kenny; Lindsey Kent; Yunjung Kim; George K Kirov; Sabine M Klauck; Lambertus Klei; James A Knowles; Martin A Kohli; Daniel L Koller; Bettina Konte; Ania Korszun; Lydia Krabbendam; Robert Krasucki; Jonna Kuntsi; Phoenix Kwan; Mikael Landén; Niklas Långström; Mark Lathrop; Jacob Lawrence; William B Lawson; Marion Leboyer; David H Ledbetter; Phil H Lee; Todd Lencz; Klaus-Peter Lesch; Douglas F Levinson; Cathryn M Lewis; Jun Li; Paul Lichtenstein; Jeffrey A Lieberman; Dan-Yu Lin; 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Caroline M Nievergelt; Ivan Nikolov; Vishwajit Nimgaonkar; Willem A Nolen; Markus M Nöthen; John I Nurnberger; Evaristus A Nwulia; Dale R Nyholt; Colm O'Dushlaine; Robert D Oades; Ann Olincy; Guiomar Oliveira; Line Olsen; Roel A Ophoff; Urban Osby; Michael J Owen; Aarno Palotie; Jeremy R Parr; Andrew D Paterson; Carlos N Pato; Michele T Pato; Brenda W Penninx; Michele L Pergadia; Margaret A Pericak-Vance; Benjamin S Pickard; Jonathan Pimm; Joseph Piven; Danielle Posthuma; James B Potash; Fritz Poustka; Peter Propping; Vinay Puri; Digby J Quested; Emma M Quinn; Josep Antoni Ramos-Quiroga; Henrik B Rasmussen; Soumya Raychaudhuri; Karola Rehnström; Andreas Reif; Marta Ribasés; John P Rice; Marcella Rietschel; Kathryn Roeder; Herbert Roeyers; Lizzy Rossin; Aribert Rothenberger; Guy Rouleau; Douglas Ruderfer; Dan Rujescu; Alan R Sanders; Stephan J Sanders; Susan L Santangelo; Joseph A Sergeant; Russell Schachar; Martin Schalling; Alan F Schatzberg; William A Scheftner; Gerard D Schellenberg; 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Authors: J Song; S E Bergen; A Di Florio; R Karlsson; A Charney; D M Ruderfer; E A Stahl; K D Chambert; J L Moran; K Gordon-Smith; L Forty; E K Green; I Jones; L Jones; E M Scolnick; P Sklar; J W Smoller; P Lichtenstein; C Hultman; N Craddock; M Landén; Jordan W Smoller; Roy H Perlis; Phil Hyoun Lee; Victor M Castro; Alison G Hoffnagle; Pamela Sklar; Eli A Stahl; Shaun M Purcell; Douglas M Ruderfer; Alexander W Charney; Panos Roussos; Carlos Pato Michele Pato; Helen Medeiros; Janet Sobel; Nick Craddock; Ian Jones; Liz Forty; Arianna Di Florio; Elaine Green; Lisa Jones; Katherine Gordon-Smith; Mikael Landen; Christina Hultman; Anders Jureus; Sarah Bergen; Steven McCarroll; Jennifer Moran; Jordan W Smoller; Kimberly Chambert; Richard A Belliveau Journal: Mol Psychiatry Date: 2015-10-27 Impact factor: 15.992
Authors: Gabriel Lázaro-Muñoz; Maya Sabatello; Laura Huckins; Holly Peay; Franziska Degenhardt; Bettina Meiser; Todd Lencz; Takahiro Soda; Anna Docherty; David Crepaz-Keay; Jehannine Austin; Roseann E Peterson; Lea K Davis Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2019-05-23 Impact factor: 3.568
Authors: Azmeraw T Amare; Klaus Oliver Schubert; Fasil Tekola-Ayele; Yi-Hsiang Hsu; Katrin Sangkuhl; Gregory Jenkins; Ryan M Whaley; Poulami Barman; Anthony Batzler; Russ B Altman; Volker Arolt; Jürgen Brockmöller; Chia-Hui Chen; Katharina Domschke; Daniel K Hall-Flavin; Chen-Jee Hong; Ari Illi; Yuan Ji; Olli Kampman; Toshihiko Kinoshita; Esa Leinonen; Ying-Jay Liou; Taisei Mushiroda; Shinpei Nonen; Michelle K Skime; Liewei Wang; Masaki Kato; Yu-Li Liu; Verayuth Praphanphoj; Julia C Stingl; William V Bobo; Shih-Jen Tsai; Michiaki Kubo; Teri E Klein; Richard M Weinshilboum; Joanna M Biernacka; Bernhard T Baune Journal: J Neural Transm (Vienna) Date: 2019-01-04 Impact factor: 3.575
Authors: C Okhuijsen-Pfeifer; M Z van der Horst; C A Bousman; B Lin; K R van Eijk; S Ripke; Y Ayhan; M O Babaoglu; M Bak; W Alink; H van Beek; E Beld; A Bouhuis; M Edlinger; I M Erdogan; A Ertuğrul; G Yoca; I P Everall; T Görlitz; K P Grootens; S Gutwinski; T Hallikainen; E Jeger-Land; M de Koning; M Lähteenvuo; S E Legge; S Leucht; C Morgenroth; A Müderrisoğlu; A Narang; C Pantelis; A F Pardiñas; T Oviedo-Salcedo; J Schneider-Thoma; S Schreiter; E Repo-Tiihonen; H Tuppurainen; M Veereschild; S Veerman; M de Vos; E Wagner; D Cohen; J P A M Bogers; J T R Walters; A E Anil Yağcıoğlu; J Tiihonen; A Hasan; J J Luykx Journal: Transl Psychiatry Date: 2022-04-07 Impact factor: 7.989
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Authors: Philip D Harvey; Tim B Bigdeli; Ayman H Fanous; Yuli Li; Nallakkandi Rajeevan; Frederick Sayward; Krishnan Radhakrishnan; Grant Huang; Mihaela Aslan Journal: Pers Med Psychiatry Date: 2021-07
Authors: Azmeraw T Amare; Klaus Oliver Schubert; Liping Hou; Scott R Clark; Sergi Papiol; Micah Cearns; Urs Heilbronner; Franziska Degenhardt; Fasil Tekola-Ayele; Yi-Hsiang Hsu; Tatyana Shekhtman; Mazda Adli; Nirmala Akula; Kazufumi Akiyama; Raffaella Ardau; Bárbara Arias; Jean-Michel Aubry; Lena Backlund; Abesh Kumar Bhattacharjee; Frank Bellivier; Antonio Benabarre; Susanne Bengesser; Joanna M Biernacka; Armin Birner; Clara Brichant-Petitjean; Pablo Cervantes; Hsi-Chung Chen; Caterina Chillotti; Sven Cichon; Cristiana Cruceanu; Piotr M Czerski; Nina Dalkner; Alexandre Dayer; Maria Del Zompo; J Raymond DePaulo; Bruno Étain; Stephane Jamain; Peter Falkai; Andreas J Forstner; Louise Frisen; Mark A Frye; Janice M Fullerton; Sébastien Gard; Julie S Garnham; Fernando S Goes; Maria Grigoroiu-Serbanescu; Paul Grof; Ryota Hashimoto; Joanna Hauser; Stefan Herms; Per Hoffmann; Andrea Hofmann; Esther Jiménez; Jean-Pierre Kahn; Layla Kassem; Po-Hsiu Kuo; Tadafumi Kato; John R Kelsoe; Sarah Kittel-Schneider; Sebastian Kliwicki; Barbara König; Ichiro Kusumi; Gonzalo Laje; Mikael Landén; Catharina Lavebratt; Marion Leboyer; Susan G Leckband; Alfonso Tortorella; Mirko Manchia; Lina Martinsson; Michael J McCarthy; Susan L McElroy; Francesc Colom; Marina Mitjans; Francis M Mondimore; Palmiero Monteleone; Caroline M Nievergelt; Markus M Nöthen; Tomas Novák; Claire O'Donovan; Norio Ozaki; Urban Ösby; Andrea Pfennig; James B Potash; Andreas Reif; Eva Reininghaus; Guy A Rouleau; Janusz K Rybakowski; Martin Schalling; Peter R Schofield; Barbara W Schweizer; Giovanni Severino; Paul D Shilling; Katzutaka Shimoda; Christian Simhandl; Claire M Slaney; Alessio Squassina; Thomas Stamm; Pavla Stopkova; Mario Maj; Gustavo Turecki; Eduard Vieta; Julia Veeh; Stephanie H Witt; Adam Wright; Peter P Zandi; Philip B Mitchell; Michael Bauer; Martin Alda; Marcella Rietschel; Francis J McMahon; Thomas G Schulze; Bernhard T Baune Journal: Mol Psychiatry Date: 2020-03-16 Impact factor: 13.437