Cheng Liu1, Rong Zhong1, Jiao Lou1, An Pan1, Yuhan Tang2, Jiang Chang3, Juntao Ke1, Jiaoyuan Li1, Jing Yuan4, Youjie Wang3, Weihong Chen4, Huan Guo4, Sheng Wei1, Yuan Liang3, Xiaomin Zhang4, Meian He4, Frank B Hu5, Tangchun Wu4, Ping Yao2, Xiaoping Miao1. 1. a Department of Epidemiology and Statistics, and the Ministry of Education (MOE) Key Lab of Environment and Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China. 2. b Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety and the Ministry of Education (MOE) Key Lab of Environment and Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China. 3. c The Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China. 4. d Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China. 5. e Department of Nutrition and Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston , USA.
Abstract
BACKGROUND: To examine the association between self-reported nighttime sleep duration and nonalcoholic fatty liver disease (NAFLD) risk by comparing the incidence rates of NAFLD among healthy subjects with different sleep duration during the 5 years follow-up. METHODS: 8965 eligible NAFLD-free subjects with a mean age of 61.6 years (males, 43.4%) from Dongfeng-Tongji cohort study at baseline were enrolled in the study. Logistic regression analysis was used to estimate the association between sleep duration and incident NAFLD with potential confounders adjusted. Sleep duration was categorized into five groups: <6 h, 6-7 h, 7-8 h, 8-9 h, ≥9 h. RESULT: During the 5-years of follow-up, a total of 2,197 participants were newly diagnosed as NAFLD. Compared with those reported 7-8 h per day of nighttime sleep, the multivariable-adjusted odds ratio (95% confidence intervals) were 1.21 (1.07-1.38) for those who sleep 8-9 h/day, and 1.31 (1.13-1.52) for those who sleep over 9 h/day. However, no significant association was found with short nightly sleep duration (<7 h/day). CONCLUSION: Long nighttime sleep duration was associated with a modestly increased risk of NAFLD in a middle-aged and elderly Chinese population. Key messages Long nighttime sleep duration was associated with a modestly increased risk of NAFLD in a middle-aged and elderly Chinese population. The effect of long nighttime sleep on the risk of incident NAFLD was attenuated greatly by body mass index (BMI) in men.
BACKGROUND: To examine the association between self-reported nighttime sleep duration and nonalcoholic fatty liver disease (NAFLD) risk by comparing the incidence rates of NAFLD among healthy subjects with different sleep duration during the 5 years follow-up. METHODS: 8965 eligible NAFLD-free subjects with a mean age of 61.6 years (males, 43.4%) from Dongfeng-Tongji cohort study at baseline were enrolled in the study. Logistic regression analysis was used to estimate the association between sleep duration and incident NAFLD with potential confounders adjusted. Sleep duration was categorized into five groups: <6 h, 6-7 h, 7-8 h, 8-9 h, ≥9 h. RESULT: During the 5-years of follow-up, a total of 2,197 participants were newly diagnosed as NAFLD. Compared with those reported 7-8 h per day of nighttime sleep, the multivariable-adjusted odds ratio (95% confidence intervals) were 1.21 (1.07-1.38) for those who sleep 8-9 h/day, and 1.31 (1.13-1.52) for those who sleep over 9 h/day. However, no significant association was found with short nightly sleep duration (<7 h/day). CONCLUSION: Long nighttime sleep duration was associated with a modestly increased risk of NAFLD in a middle-aged and elderly Chinese population. Key messages Long nighttime sleep duration was associated with a modestly increased risk of NAFLD in a middle-aged and elderly Chinese population. The effect of long nighttime sleep on the risk of incident NAFLD was attenuated greatly by body mass index (BMI) in men.
Authors: Kathryn E Royse; Hashem B El-Serag; Liang Chen; Donna L White; Lauren Hale; Haleh Sangi-Haghpeykar; Li Jiao Journal: J Womens Health (Larchmt) Date: 2017-09-21 Impact factor: 2.681
Authors: Bertha Araceli Marin-Alejandre; Itziar Abete; Irene Cantero; Jose I Riezu-Boj; Fermín I Milagro; J Ignacio Monreal; Mariana Elorz; José Ignacio Herrero; Alberto Benito-Boillos; Jorge Quiroga; Ana Martinez-Echeverria; Juan Isidro Uriz-Otano; María Pilar Huarte-Muniesa; Josep A Tur; J Alfredo Martínez; M Angeles Zulet Journal: Nutrients Date: 2019-02-02 Impact factor: 5.717
Authors: Yoo Jin Um; Yoosoo Chang; Hyun-Suk Jung; In Young Cho; Jun Ho Shin; Hocheol Shin; Sarah H Wild; Christopher D Byrne; Seungho Ryu Journal: Clin Transl Gastroenterol Date: 2021-10-19 Impact factor: 4.488