Kathryn E Royse1,2, Hashem B El-Serag1,2,3,4, Liang Chen1,2, Donna L White1,2,3,4,5, Lauren Hale6, Haleh Sangi-Haghpeykar7, Li Jiao1,2,3,4,5. 1. 1 Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine , Houston, Texas. 2. 2 Center for Innovations in Quality, Effectiveness and Safety (iQuEST), Michael E. DeBakey VA Medical Center , Houston, Texas. 3. 3 Texas Medical Center Digestive Disease Center , Houston, Texas. 4. 4 Dan L. Duncan Cancer Center , Baylor College of Medicine, Houston, Texas. 5. 5 Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center , Houston, Texas. 6. 6 Program in Public Health, School of Medicine, Family, Population and Preventive Medicine, Stony Brook University , Stony Brook, New York. 7. 7 Department of Obstetrics and Gynecology, Baylor College of Medicine , Houston, Texas.
Abstract
BACKGROUND: Sleep duration has been associated with nonalcoholic fatty liver disease, but its association with liver cancer remains unknown. MATERIAL AND METHODS: In the prospective Women's Health Initiative Study, 139,368 postmenopausal women reported sleep habits at baseline (1993-1998). We ascertained 175 incident liver cancer cases during an average 13.8 years of follow-up through August 2014. We used multivariable Cox proportional hazard regression models to estimate a hazard ratio (HR) and its 95% confidence interval (95% CI) for risk of liver cancer in association with nocturnal sleep duration. RESULTS: Compared to women reporting 6-8 hours of sleep, the HR for liver cancer was 1.94 (95% CI 1.07-3.53) for women reporting ≥9 hours of sleep. Among the obese women, the HR associated with ≥9 hours of sleep was 3.18 (95% CI 1.84-8.60). The HR was 0.93 (95% CI 0.34-2.53) among nonobese women (p value for interaction = 0.18). Short sleep duration (≤5 hours) was not associated with liver cancer risk. CONCLUSION: Long sleep duration was associated with a moderate increase in liver cancer risk in obese postmenopausal women in the United States. Larger study is needed to confirm our observation on effect modification by adiposity status.
BACKGROUND: Sleep duration has been associated with nonalcoholic fatty liver disease, but its association with liver cancer remains unknown. MATERIAL AND METHODS: In the prospective Women's Health Initiative Study, 139,368 postmenopausal women reported sleep habits at baseline (1993-1998). We ascertained 175 incident liver cancer cases during an average 13.8 years of follow-up through August 2014. We used multivariable Cox proportional hazard regression models to estimate a hazard ratio (HR) and its 95% confidence interval (95% CI) for risk of liver cancer in association with nocturnal sleep duration. RESULTS: Compared to women reporting 6-8 hours of sleep, the HR for liver cancer was 1.94 (95% CI 1.07-3.53) for women reporting ≥9 hours of sleep. Among the obesewomen, the HR associated with ≥9 hours of sleep was 3.18 (95% CI 1.84-8.60). The HR was 0.93 (95% CI 0.34-2.53) among nonobese women (p value for interaction = 0.18). Short sleep duration (≤5 hours) was not associated with liver cancer risk. CONCLUSION: Long sleep duration was associated with a moderate increase in liver cancer risk in obese postmenopausal women in the United States. Larger study is needed to confirm our observation on effect modification by adiposity status.
Authors: J David Curb; Anne McTiernan; Susan R Heckbert; Charles Kooperberg; Janet Stanford; Michael Nevitt; Karen C Johnson; Lori Proulx-Burns; Lisa Pastore; Michael Criqui; Sandra Daugherty Journal: Ann Epidemiol Date: 2003-10 Impact factor: 3.797
Authors: Hung N Luu; Jaideep Behari; George Boon-Bee Goh; Renwei Wang; Aizhen Jin; Claire E Thomas; Jose C Clemente; Andrew O Odegaard; Woon-Puay Koh; Jian-Min Yuan Journal: Cancer Epidemiol Biomarkers Prev Date: 2020-11-13 Impact factor: 4.090