Literature DB >> 27326654

Toll-like receptor 2 in host defense against Mycobacterium tuberculosis: to be or not to be-that is the question.

Archana Gopalakrishnan1, Padmini Salgame2.   

Abstract

Toll-like receptor (TLR) 2 is expressed on immune cells and respiratory epithelial cells lining the lung. TLR2 is not critical for protection during acute Mycobacterium tuberculosis (Mtb) infection but it has a significant multi-faceted role in containing chronic infection. This review highlights the contribution of TLR2 to host protection, immune evasion by Mtb and immune regulation during chronic Mtb infection. The TLR2-triggered pro-inflammatory cytokines initiate protective mechanisms and limit Mtb replication while the immune evasion pathways counterattack anti-bacterial effector mechanisms. The immune regulation pathways that are activated dampen TLR2 signaling. The combinatorial effect of these functional responses is persistence of Mtb with minimal immunopathology.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27326654      PMCID： PMC5086274          DOI： 10.1016/j.coi.2016.06.003

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  68 in total

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Journal:  Mol Microbiol       Date:  1999-03       Impact factor: 3.501

Review 2.  The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.

Authors:  Taro Kawai; Shizuo Akira
Journal:  Nat Immunol       Date:  2010-04-20       Impact factor: 25.606

3.  Role of Toll-like receptor 2 (-196 to -174) polymorphism in susceptibility to pulmonary tuberculosis in Pakistani population.

Authors:  Abrar-Ul-Haq Khan; M A Aslam; I Hussain; A G Naz; I A Rana; M M Ahmad; M Ali; S Ahmad
Journal:  Int J Immunogenet       Date:  2013-09-03       Impact factor: 1.466

4.  Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.

Authors:  Philip T Liu; Steffen Stenger; Dominic H Tang; Robert L Modlin
Journal:  J Immunol       Date:  2007-08-15       Impact factor: 5.422

5.  R753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88.

Authors:  Yanbao Xiong; Chang Song; Greg A Snyder; Eric J Sundberg; Andrei E Medvedev
Journal:  J Biol Chem       Date:  2012-09-19       Impact factor: 5.157

6.  Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.

Authors:  Rafael Prados-Rosales; Andres Baena; Luis R Martinez; Jose Luque-Garcia; Rainer Kalscheuer; Usha Veeraraghavan; Carmen Camara; Joshua D Nosanchuk; Gurdyal S Besra; Bing Chen; Juan Jimenez; Aharona Glatman-Freedman; William R Jacobs; Steven A Porcelli; Arturo Casadevall
Journal:  J Clin Invest       Date:  2011-04       Impact factor: 14.808

7.  Genetic diversity of TLR2, TLR4, and VDR loci and pulmonary tuberculosis in Moroccan patients.

Authors:  Naima Arji; Marc Busson; Ghali Iraqi; Jamal Eddine Bourkadi; Abdelaziz Benjouad; Abdellatif Bouayad; Christina Mariaselvam; Sofiane Salah; Catherine Fortier; Kahina Amokrane; François Marzais; Wahid Boukouaci; Rajagopal Krishnamoorthy; Dominique Charron; Rajae El Aouad; Ryad Tamouza
Journal:  J Infect Dev Ctries       Date:  2014-04-15       Impact factor: 0.968

8.  Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.

Authors:  Poonam Rath; Chengdong Huang; Tao Wang; Tianzhi Wang; Huilin Li; Rafael Prados-Rosales; Olivier Elemento; Arturo Casadevall; Carl F Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-18       Impact factor: 11.205

Review 9.  Toll-like receptor -1, -2, and -6 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis.

Authors:  Yuxiang Zhang; Tingting Jiang; Xiuyun Yang; Yun Xue; Chong Wang; Jiyan Liu; Xing Zhang; Zhongliang Chen; Mengyuan Zhao; Ji-Cheng Li
Journal:  PLoS One       Date:  2013-05-14       Impact factor: 3.240

10.  The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis.

Authors:  Maxine Caws; Guy Thwaites; Sarah Dunstan; Thomas R Hawn; Nguyen Thi Ngoc Lan; Nguyen Thuy Thuong Thuong; Kasia Stepniewska; Mai Nguyet Thu Huyen; Nguyen Duc Bang; Tran Huu Loc; Sebastien Gagneux; Dick van Soolingen; Kristin Kremer; Marianne van der Sande; Peter Small; Phan Thi Hoang Anh; Nguyen Tran Chinh; Hoang Thi Quy; Nguyen Thi Hong Duyen; Dau Quang Tho; Nguyen T Hieu; Estee Torok; Tran Tinh Hien; Nguyen Huy Dung; Nguyen Thi Quynh Nhu; Phan Minh Duy; Nguyen van Vinh Chau; Jeremy Farrar
Journal:  PLoS Pathog       Date:  2008-03-28       Impact factor: 6.823
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  22 in total

1.  Mycobacterium tuberculosis PPE60 antigen drives Th1/Th17 responses via Toll-like receptor 2-dependent maturation of dendritic cells.

Authors:  Haibo Su; Zhen Zhang; Zijian Liu; Baozhou Peng; Cong Kong; Honghai Wang; Zhi Zhang; Ying Xu
Journal:  J Biol Chem       Date:  2018-05-08       Impact factor: 5.157

2.  Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling.

Authors:  Madlen Hansen; Julian Peltier; Barbara Killy; Bushra Amin; Barbara Bodendorfer; Anetta Härtlova; Sebastian Uebel; Markus Bosmann; Jörg Hofmann; Christian Büttner; Arif B Ekici; Mario Kuttke; Henrik Franzyk; Camilla Foged; Sandra Beer-Hammer; Gernot Schabbauer; Matthias Trost; Roland Lang
Journal:  Mol Cell Proteomics       Date:  2019-01-11       Impact factor: 5.911

Review 3.  TLRs in Mycobacterial Pathogenesis: Black and White or Shades of Gray.

Authors:  Priyanka Mehta; Atish Ray; Shibnath Mazumder
Journal:  Curr Microbiol       Date:  2021-04-12       Impact factor: 2.188

4.  Mycobacterium tuberculosis DosR Regulon Gene Rv2004c Encodes a Novel Antigen with Pro-inflammatory Functions and Potential Diagnostic Application for Detection of Latent Tuberculosis.

Authors:  Sankara Narayana Doddam; Vidyullatha Peddireddy; Niyaz Ahmed
Journal:  Front Immunol       Date:  2017-06-24       Impact factor: 7.561

5.  Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion.

Authors:  Anna K O Rode; Martin Kongsbak; Marie M Hansen; Daniel Villalba Lopez; Trine B Levring; Anders Woetmann; Niels Ødum; Charlotte M Bonefeld; Carsten Geisler
Journal:  Front Immunol       Date:  2017-05-31       Impact factor: 7.561

6.  c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a.

Authors:  Kasturi Mahadik; Praveen Prakhar; R S Rajmani; Amit Singh; Kithiganahalli Narayanaswamy Balaji
Journal:  Front Immunol       Date:  2018-02-01       Impact factor: 7.561

7.  Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer.

Authors:  Zhen Wang; Chenghui Yang; Lili Li; Xiaoyan Jin; Zhigang Zhang; Haiyan Zheng; Jun Pan; Liyun Shi; Zhou Jiang; Ke Su; Baizhou Li; Xuan Shao; Fuming Qiu; Jun Yan; Jian Huang
Journal:  Oncogenesis       Date:  2020-09-17       Impact factor: 7.485

8.  CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.

Authors:  Qianting Yang; Mingfeng Liao; Wenfei Wang; Mingxia Zhang; Qi Chen; Jiubiao Guo; Bin Peng; Jian Huang; Haiying Liu; Ayano Yahagi; Xingzhi Xu; Katsuhiko Ishihara; Andrea Cooper; Xinchun Chen; Yi Cai
Journal:  mBio       Date:  2019-08-27       Impact factor: 7.867

9.  Allelic-Specific Regulation of xCT Expression Increases Susceptibility to Tuberculosis by Modulating microRNA-mRNA Interactions.

Authors:  Wenfei Wang; Yi Cai; Guofang Deng; Qianting Yang; Peijun Tang; Meiying Wu; Ziqi Yu; Fan Yang; Jianyong Chen; Oliver Werz; Xinchun Chen
Journal:  mSphere       Date:  2020-04-22       Impact factor: 4.389

10.  Toll-like receptor 9 and 4 gene polymorphisms in susceptibility and severity of malaria: a meta-analysis of genetic association studies.

Authors:  Cho Naing; Siew Tung Wong; Htar Htar Aung
Journal:  Malar J       Date:  2021-07-03       Impact factor: 2.979
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