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Literature DB >> 24248369

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.

Poonam Rath¹, Chengdong Huang, Tao Wang, Tianzhi Wang, Huilin Li, Rafael Prados-Rosales, Olivier Elemento, Arturo Casadevall, Carl F Nathan.

Abstract

Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."

Entities: Gene Species

Keywords: TLR2; macrophages

Mesh：

Substances：

Year: 2013 PMID： 24248369 PMCID： PMC3856836 DOI： 10.1073/pnas.1320118110

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

48 in total

1. Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo.

Authors: Prachi P Singh; Victoria L Smith; Petros C Karakousis; Jeffery S Schorey
Journal: J Immunol Date: 2012-06-20 Impact factor: 5.422

2. A convenient and sensitive fluorescence assay for phospholipid vesicles using diphenylhexatriene.

Authors: E London; G W Feligenson
Journal: Anal Biochem Date: 1978-07-15 Impact factor: 3.365

3. In vitro differentiation of human macrophages with enhanced antimycobacterial activity.

Authors: Guillaume Vogt; Carl Nathan
Journal: J Clin Invest Date: 2011-09-12 Impact factor: 14.808

4. Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.

Authors: Rafael Prados-Rosales; Andres Baena; Luis R Martinez; Jose Luque-Garcia; Rainer Kalscheuer; Usha Veeraraghavan; Carmen Camara; Joshua D Nosanchuk; Gurdyal S Besra; Bing Chen; Juan Jimenez; Aharona Glatman-Freedman; William R Jacobs; Steven A Porcelli; Arturo Casadevall
Journal: J Clin Invest Date: 2011-04 Impact factor: 14.808

5. Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved.

Authors: Iñaki Comas; Jaidip Chakravartti; Peter M Small; James Galagan; Stefan Niemann; Kristin Kremer; Joel D Ernst; Sebastien Gagneux
Journal: Nat Genet Date: 2010-05-23 Impact factor: 38.330

6. Role of Pseudomonas aeruginosa peptidoglycan-associated outer membrane proteins in vesicle formation.

Authors: Aimee K Wessel; Jean Liew; Taejoon Kwon; Edward M Marcotte; Marvin Whiteley
Journal: J Bacteriol Date: 2012-11-02 Impact factor: 3.490

7. Mycobacterium tuberculosis produces pili during human infection.

Authors: Christopher J Alteri; Juan Xicohténcatl-Cortes; Sonja Hess; Guillermo Caballero-Olín; Jorge A Girón; Richard L Friedman
Journal: Proc Natl Acad Sci U S A Date: 2007-03-08 Impact factor: 11.205

Review 8. The immunological life cycle of tuberculosis.

Authors: Joel D Ernst
Journal: Nat Rev Immunol Date: 2012-07-13 Impact factor: 53.106

9. A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion.

Authors: Sandra M Newton; Rebecca J Smith; Katalin A Wilkinson; Mark P Nicol; Natalie J Garton; Karl J Staples; Graham R Stewart; John R Wain; Adrian R Martineau; Sarah Fandrich; Timothy Smallie; Brian Foxwell; Ahmed Al-Obaidi; Jamila Shafi; Kumar Rajakumar; Beate Kampmann; Peter W Andrew; Loems Ziegler-Heitbrock; Michael R Barer; Robert J Wilkinson
Journal: Proc Natl Acad Sci U S A Date: 2006-10-06 Impact factor: 11.205

10. Lipid exchange between Borrelia burgdorferi and host cells.

Authors: Jameson T Crowley; Alvaro M Toledo; Timothy J LaRocca; James L Coleman; Erwin London; Jorge L Benach
Journal: PLoS Pathog Date: 2013-01-10 Impact factor: 6.823

42 in total

1. Membrane vesicles in sea water: heterogeneous DNA content and implications for viral abundance estimates.

Authors: Steven J Biller; Lauren D McDaniel; Mya Breitbart; Everett Rogers; John H Paul; Sallie W Chisholm
Journal: ISME J Date: 2016-11-08 Impact factor: 10.302

2. Divergent Functions of TLR2 on Hematopoietic and Nonhematopoietic Cells during Chronic Mycobacterium tuberculosis Infection.

Authors: Jill Konowich; Archana Gopalakrishnan; Jillian Dietzold; Sheetal Verma; Kamlesh Bhatt; Wasiulla Rafi; Padmini Salgame
Journal: J Immunol Date: 2016-12-05 Impact factor: 5.422

Review 3. Toll-like receptor 2 in host defense against Mycobacterium tuberculosis: to be or not to be-that is the question.

Authors: Archana Gopalakrishnan; Padmini Salgame
Journal: Curr Opin Immunol Date: 2016-06-18 Impact factor: 7.486

4. Role for Mycobacterium tuberculosis membrane vesicles in iron acquisition.

Authors: Rafael Prados-Rosales; Brian C Weinrick; Daniel G Piqué; William R Jacobs; Arturo Casadevall; G Marcela Rodriguez
Journal: J Bacteriol Date: 2014-01-10 Impact factor: 3.490

Review 5. Extracellular Vesicle Biogenesis and Functions in Gram-Positive Bacteria.

Authors: Paul Briaud; Ronan K Carroll
Journal: Infect Immun Date: 2020-11-16 Impact factor: 3.441

6. Toll-like Receptor 2 Prevents Neutrophil-Driven Immunopathology during Infection with Mycobacterium tuberculosis by Curtailing CXCL5 Production.

Authors: Archana Gopalakrishnan; Jillian Dietzold; Sheetal Verma; Madhuri Bhagavathula; Padmini Salgame
Journal: Infect Immun Date: 2019-02-21 Impact factor: 3.441

7. Mycobacterium tuberculosis Rv2700 Contributes to Cell Envelope Integrity and Virulence.

Authors: Edward R Ballister; Marie I Samanovic; K Heran Darwin
Journal: J Bacteriol Date: 2019-09-06 Impact factor: 3.490

8. Bacterial Membrane Vesicles Mediate the Release of Mycobacterium tuberculosis Lipoglycans and Lipoproteins from Infected Macrophages.

Authors: Jaffre J Athman; Ying Wang; David J McDonald; W Henry Boom; Clifford V Harding; Pamela A Wearsch
Journal: J Immunol Date: 2015-06-24 Impact factor: 5.422

Review 9. A bug's life in the granuloma.

Authors: Constance J Martin; Allison F Carey; Sarah M Fortune
Journal: Semin Immunopathol Date: 2015-11-17 Impact factor: 9.623

Review 10. Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi.

Authors: Lisa Brown; Julie M Wolf; Rafael Prados-Rosales; Arturo Casadevall
Journal: Nat Rev Microbiol Date: 2015-09-01 Impact factor: 60.633