| Literature DB >> 27320129 |
Merly Escalona1, Sara Rocha1, David Posada1,2.
Abstract
Computer simulation of genomic data has become increasingly popular for assessing and validating biological models or for gaining an understanding of specific data sets. Several computational tools for the simulation of next-generation sequencing (NGS) data have been developed in recent years, which could be used to compare existing and new NGS analytical pipelines. Here we review 23 of these tools, highlighting their distinct functionality, requirements and potential applications. We also provide a decision tree for the informed selection of an appropriate NGS simulation tool for the specific question at hand.Entities:
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Year: 2016 PMID： 27320129 PMCID： PMC5224698 DOI： 10.1038/nrg.2016.57
Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242