Literature DB >> 27314083

H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach.

Emily Z Keung1, Kunal Rai2.   

Abstract

The pathogenesis of well-differentiated and dedifferentiated liposarcoma is poorly understood. We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma. Mechanistically, KLF6 may drive adipocytic differentiation through increased expression of known regulators of adipogenesis.

Entities:  

Keywords:  Dedifferentiated; H3K9me3; KLF6; epigenetics; liposarcoma; well differentiated

Year:  2015        PMID： 27314083      PMCID： PMC4909467          DOI： 10.1080/23723556.2015.1093691

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma.

Authors:  Aimee M Crago; Samuel Singer
Journal:  Curr Opin Oncol       Date:  2011-07       Impact factor: 3.645

Review 2.  Liposarcoma: new entities and evolving concepts.

Authors:  A P Dei Tos
Journal:  Ann Diagn Pathol       Date:  2000-08       Impact factor: 2.090

3.  Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma.

Authors:  Emily Z Keung; Kadir C Akdemir; Ghadah A Al Sannaa; Jeannine Garnett; Dina Lev; Keila E Torres; Alexander J Lazar; Kunal Rai; Lynda Chin
Journal:  J Clin Invest       Date:  2015-07-20       Impact factor: 14.808

4.  Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas.

Authors:  Barry S Taylor; Penelope L DeCarolis; Christina V Angeles; Fabienne Brenet; Nikolaus Schultz; Cristina R Antonescu; Joseph M Scandura; Chris Sander; Agnes J Viale; Nicholas D Socci; Samuel Singer
Journal:  Cancer Discov       Date:  2011-12       Impact factor: 39.397

5.  Similarity in genetic alterations between paired well-differentiated and dedifferentiated components of dedifferentiated liposarcoma.

Authors:  Andrew E Horvai; Sandy DeVries; Ritu Roy; Richard J O'Donnell; Frederic Waldman
Journal:  Mod Pathol       Date:  2009-09-04       Impact factor: 7.842

Review 6.  Well-differentiated and dedifferentiated liposarcomas.

Authors:  Jean-Michel Coindre; Florence Pédeutour; Alain Aurias
Journal:  Virchows Arch       Date:  2009-08-18       Impact factor: 4.064

7.  Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study.

Authors:  Isabelle Ray-Coquard; Jean-Yves Blay; Antoine Italiano; Axel Le Cesne; Nicolas Penel; Jianguo Zhi; Florian Heil; Ruediger Rueger; Bradford Graves; Meichun Ding; David Geho; Steven A Middleton; Lyubomir T Vassilev; Gwen L Nichols; Binh Nguyen Bui
Journal:  Lancet Oncol       Date:  2012-10-17       Impact factor: 41.316

8.  An experimental model for the study of well-differentiated and dedifferentiated liposarcoma; deregulation of targetable tyrosine kinase receptors.

Authors:  Tingsheng Peng; Pingyu Zhang; Jeffery Liu; Theresa Nguyen; Svetlana Bolshakov; Roman Belousov; Eric D Young; Xiaoke Wang; Kari Brewer; Delores H López-Terrada; Andre M Oliveira; Alexander J Lazar; Dina Lev
Journal:  Lab Invest       Date:  2010-11-08       Impact factor: 5.662

9.  Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas.

Authors:  Marcus Renner; Thomas Wolf; Hannah Meyer; Wolfgang Hartmann; Roland Penzel; Alexis Ulrich; Burkhard Lehner; Volker Hovestadt; Esteban Czwan; Gerlinde Egerer; Thomas Schmitt; Ingo Alldinger; Eva Kristin Renker; Volker Ehemann; Roland Eils; Eva Wardelmann; Reinhard Büttner; Peter Lichter; Benedikt Brors; Peter Schirmacher; Gunhild Mechtersheimer
Journal:  Genome Biol       Date:  2013-12-17       Impact factor: 13.583
  9 in total
  1 in total

1.  Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin.

Authors:  Hannah C Beird; Chia-Chin Wu; Davis R Ingram; Wei-Lien Wang; Asrar Alimohamed; Curtis Gumbs; Latasha Little; Xingzhi Song; Barry W Feig; Christina L Roland; Jianhua Zhang; Robert S Benjamin; Patrick Hwu; Alexander J Lazar; P Andrew Futreal; Neeta Somaiah
Journal:  Cold Spring Harb Mol Case Stud       Date:  2018-04-02
  1 in total

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