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Literature DB >> 19688222

Well-differentiated and dedifferentiated liposarcomas.

Jean-Michel Coindre¹, Florence Pédeutour, Alain Aurias.

Abstract

Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.

Entities: Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19688222 DOI： 10.1007/s00428-009-0815-x

Source DB: PubMed Journal: Virchows Arch ISSN： 0945-6317 Impact factor: 4.064

41 in total

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Journal: Biochim Biophys Acta Date: 2002-03-14

7. Dedifferentiated liposarcoma: a report of nine cases with a peculiar neurallike whorling pattern associated with metaplastic bone formation.

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8. Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas.

Authors: Matthieu Bui Nguyen Binh; Louis Guillou; Isabelle Hostein; Marie Christine Château; Francoise Collin; Alain Aurias; Bui Nguyen Binh; Eberhard Stoeckle; Jean-Michel Coindre
Journal: Am J Surg Pathol Date: 2007-10 Impact factor: 6.394

9. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR.

Authors: Nicolas Sirvent; Jean-Michel Coindre; Georges Maire; Isabelle Hostein; Frédérique Keslair; Louis Guillou; Dominique Ranchere-Vince; Philippe Terrier; Florence Pedeutour
Journal: Am J Surg Pathol Date: 2007-10 Impact factor: 6.394

10. The prognostic impact of dedifferentiation in retroperitoneal liposarcoma: a series of surgically treated patients at a single institution.

Authors: Chiara Mussi; Paola Collini; Rosalba Miceli; Marta Barisella; Luigi Mariani; Marco Fiore; Paolo G Casali; Alessandro Gronchi
Journal: Cancer Date: 2008-10-01 Impact factor: 6.860

76 in total

1. [Sarcomas: classification with morphologic and genetic criteria].

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Journal: Pathologe Date: 2011-02 Impact factor: 1.011

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Authors: F Chibon; J-M Coindre
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3. Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement.

Authors: Kayo Suzuki; Taketoshi Yasuda; Kenta Watanabe; Takeshi Hori; Masahiko Kanamori; Tomoatsu Kimura
Journal: Oncol Lett Date: 2017-09-25 Impact factor: 2.967

4. Activation of the Akt-mTOR and MAPK pathways in dedifferentiated liposarcomas.

Authors: Takeaki Ishii; Kenichi Kohashi; Kunio Iura; Akira Maekawa; Hirofumi Bekki; Yuichi Yamada; Hidetaka Yamamoto; Kazuki Nabeshima; Hiroyuki Kawashima; Yukihide Iwamoto; Yoshinao Oda
Journal: Tumour Biol Date: 2015-10-30

5. Thoracoscopic resection of a huge esophageal dedifferentiated liposarcoma: A case report.

Authors: Yi-Wang Ye; Meng-Ying Liao; Zhi-Min Mou; Xiao-Xin Shi; Yuan-Cai Xie
Journal: World J Clin Cases Date: 2020-05-06 Impact factor: 1.337

6. Magnetic Resonance Imaging Assessment of Lipomatous Soft-tissue Tumors.

Authors: Alessandro Coran; Paolo Ortolan; Shady Attar; Enrico Alberioli; Egle Perissinotto; Anna Lisa Tosi; Maria Cristina Montesco; Carlo Riccardo Rossi; Saveria Tropea; Marco Rastrelli; Roberto Stramare
Journal: In Vivo Date: 2017 May-Jun Impact factor: 2.155

Review 7. The Role of MDM2 Amplification and Overexpression in Tumorigenesis.

Authors: Jonathan D Oliner; Anne Y Saiki; Sean Caenepeel
Journal: Cold Spring Harb Perspect Med Date: 2016-06-01 Impact factor: 6.915

8. Multicystic dedifferentiated retroperitoneal liposarcoma: tumour cyst fluid analysis and implications for management.

Authors: Mitri Khoury; Geok Choo Sim; Michiko Harao; Laszlo Radvanyi; Behrang Amini; Robert S Benjamin; Peter W T Pisters; Raphael E Pollock; William W Tseng
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9. Inverse association between MDM2 and HUWE1 protein expression levels in human breast cancer and liposarcoma.

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10. Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma?

Authors: Priya Bhosale; Jieqi Wang; Datla Varma; Corey Jensen; Madhavi Patnana; Wei Wei; Anil Chauhan; Barry Feig; Shreyaskumar Patel; Neeta Somaiah; Tara Sagebiel
Journal: J Comput Assist Tomogr Date: 2016 Nov/Dec Impact factor: 1.826