Literature DB >> 27308615

TopBP1 makes the final call for repair on the verge of cell division.

Vibe H Oestergaard1, Michael Lisby1.   

Abstract

Mitosis is the process responsible for segregation of the duplicated genome into 2 new daughter cells. We recently identified an important function of the protein TopBP1 during mitosis by showing that TopBP1 suppresses transmission of DNA damage to daughter cells. Here, we further discuss the implications of our findings.

Entities:  

Keywords:  Anaphase; DNA repair; mitosis; mutagenesis; SLX4; TopBP1; unscheduled DNA synthesis; 53BP1 nuclear bodies

Year:  2015        PMID： 27308615      PMCID： PMC4905401          DOI： 10.1080/23723556.2015.1093066

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress.

Authors:  Claudia Lukas; Velibor Savic; Simon Bekker-Jensen; Carsten Doil; Beate Neumann; Ronni Sølvhøj Pedersen; Merete Grøfte; Kok Lung Chan; Ian David Hickson; Jiri Bartek; Jiri Lukas
Journal:  Nat Cell Biol       Date:  2011-02-13       Impact factor: 28.824

2.  Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.

Authors:  Jian Ouyang; Elizabeth Garner; Alexander Hallet; Hai Dang Nguyen; Kimberly A Rickman; Grace Gill; Agata Smogorzewska; Lee Zou
Journal:  Mol Cell       Date:  2014-12-18       Impact factor: 17.970

3.  Signatures of mutation and selection in the cancer genome.

Authors:  Graham R Bignell; Chris D Greenman; Helen Davies; Adam P Butler; Sarah Edkins; Jenny M Andrews; Gemma Buck; Lina Chen; David Beare; Calli Latimer; Sara Widaa; Jonathon Hinton; Ciara Fahey; Beiyuan Fu; Sajani Swamy; Gillian L Dalgliesh; Bin T Teh; Panos Deloukas; Fengtang Yang; Peter J Campbell; P Andrew Futreal; Michael R Stratton
Journal:  Nature       Date:  2010-02-18       Impact factor: 49.962

4.  Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

Authors:  Benoît Le Tallec; Gaël Armel Millot; Marion Esther Blin; Olivier Brison; Bernard Dutrillaux; Michelle Debatisse
Journal:  Cell Rep       Date:  2013-08-01       Impact factor: 9.423

Review 5.  Holliday junction resolution: regulation in space and time.

Authors:  Joao Matos; Stephen C West
Journal:  DNA Repair (Amst)       Date:  2014-04-24

6.  The landscape of somatic copy-number alteration across human cancers.

Authors:  Rameen Beroukhim; Craig H Mermel; Dale Porter; Guo Wei; Soumya Raychaudhuri; Jerry Donovan; Jordi Barretina; Jesse S Boehm; Jennifer Dobson; Mitsuyoshi Urashima; Kevin T Mc Henry; Reid M Pinchback; Azra H Ligon; Yoon-Jae Cho; Leila Haery; Heidi Greulich; Michael Reich; Wendy Winckler; Michael S Lawrence; Barbara A Weir; Kumiko E Tanaka; Derek Y Chiang; Adam J Bass; Alice Loo; Carter Hoffman; John Prensner; Ted Liefeld; Qing Gao; Derek Yecies; Sabina Signoretti; Elizabeth Maher; Frederic J Kaye; Hidefumi Sasaki; Joel E Tepper; Jonathan A Fletcher; Josep Tabernero; José Baselga; Ming-Sound Tsao; Francesca Demichelis; Mark A Rubin; Pasi A Janne; Mark J Daly; Carmelo Nucera; Ross L Levine; Benjamin L Ebert; Stacey Gabriel; Anil K Rustgi; Cristina R Antonescu; Marc Ladanyi; Anthony Letai; Levi A Garraway; Massimo Loda; David G Beer; Lawrence D True; Aikou Okamoto; Scott L Pomeroy; Samuel Singer; Todd R Golub; Eric S Lander; Gad Getz; William R Sellers; Matthew Meyerson
Journal:  Nature       Date:  2010-02-18       Impact factor: 49.962

7.  TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells.

Authors:  Rune Troelsgaard Pedersen; Thomas Kruse; Jakob Nilsson; Vibe H Oestergaard; Michael Lisby
Journal:  J Cell Biol       Date:  2015-08-17       Impact factor: 10.539

8.  TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability.

Authors:  Susanne M Germann; Vera Schramke; Rune Troelsgaard Pedersen; Irene Gallina; Nadine Eckert-Boulet; Vibe H Oestergaard; Michael Lisby
Journal:  J Cell Biol       Date:  2013-12-30       Impact factor: 10.539
  8 in total
  1 in total

1.  Immunostaining of Formaldehyde-fixed Metaphase Chromosome from Untreated and Aphidicolin-treated DT40 Cells.

Authors:  Vibe H Oestergaard
Journal:  Bio Protoc       Date:  2017-05-05
  1 in total

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