Jie Yang1, Wenqian Huo1, Bin Zhang2, Tongzhang Zheng3, Yuanyuan Li1, Xinyun Pan1, Wenyu Liu1, Huailong Chang1, Minmin Jiang1, Aifen Zhou2, Zhengmin Qian4, Yanjian Wan1, Wei Xia5, Shunqing Xu6. 1. Key Laboratory of Environment and Health (Huazhong University of Science and Technology), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. 2. Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, People's Republic of China. 3. Department of Environmental Health Sciences, Brown School of Public Health, Providence, RI, USA. 4. Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, St. Louis, MO, USA. 5. Key Laboratory of Environment and Health (Huazhong University of Science and Technology), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: xiawei@hust.edu.cn. 6. Key Laboratory of Environment and Health (Huazhong University of Science and Technology), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: xust@hust.edu.cn.
Abstract
BACKGROUND: Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. The aim of this study was to evaluate the association between prenatal Cd exposure and birth outcomes. METHODS: This study was conducted in 5364 pregnant women with a live singleton birth, who were recruited between September 2012 and October 2014 in the Healthy Baby Cohort (HBC) in Wuhan, China. Gestational age (in days) was estimated using both the woman's last menstrual period (LMP) and ultrasound data. All the birth outcomes including birth weight and birth length were measured in the hospital within one hour after birth through standardized procedures. Cd was measured in maternal urine collected before delivery with inductively coupled plasma mass spectrometry. RESULTS: The geometric mean of Cd concentration in maternal urine was 0.55 (range 0.01-2.85) μg/g creatinine. We found each ln-unit increase in Cd concentration (μg/g creatinine) in maternal urine was associated with decreased gestational age [adjusted β=-0.77day; 95% confidence interval (CI): -1.15, -0.39 for all infants; -0.77; 95% CI: -1.29, -0.25 for boys; and -0.80; 95% CI: -1.35, -0.25 for girls]. Increased likelihood of preterm birth (PTB) was associated with ln-unit increase in urinary Cd (μg/g creatinine) [adjusted odds ratio (OR)=1.78; 95% CI: 1.45, 2.19 for all infants; 1.97; 95% CI: 1.46, 2.65 for boys; and 1.67; 95% CI: 1.24, 2.25 for girls]. Maternal urinary Cd was not significantly associated with low birth weight (LBW) and small for gestational age (SGA). CONCLUSIONS: Maternal exposure to Cd during pregnancy was associated with decreased gestational age and increased likelihood of PTB.
BACKGROUND: Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. The aim of this study was to evaluate the association between prenatal Cd exposure and birth outcomes. METHODS: This study was conducted in 5364 pregnant women with a live singleton birth, who were recruited between September 2012 and October 2014 in the Healthy Baby Cohort (HBC) in Wuhan, China. Gestational age (in days) was estimated using both the woman's last menstrual period (LMP) and ultrasound data. All the birth outcomes including birth weight and birth length were measured in the hospital within one hour after birth through standardized procedures. Cd was measured in maternal urine collected before delivery with inductively coupled plasma mass spectrometry. RESULTS: The geometric mean of Cd concentration in maternal urine was 0.55 (range 0.01-2.85) μg/g creatinine. We found each ln-unit increase in Cd concentration (μg/g creatinine) in maternal urine was associated with decreased gestational age [adjusted β=-0.77day; 95% confidence interval (CI): -1.15, -0.39 for all infants; -0.77; 95% CI: -1.29, -0.25 for boys; and -0.80; 95% CI: -1.35, -0.25 for girls]. Increased likelihood of preterm birth (PTB) was associated with ln-unit increase in urinary Cd (μg/g creatinine) [adjusted odds ratio (OR)=1.78; 95% CI: 1.45, 2.19 for all infants; 1.97; 95% CI: 1.46, 2.65 for boys; and 1.67; 95% CI: 1.24, 2.25 for girls]. Maternal urinary Cd was not significantly associated with low birth weight (LBW) and small for gestational age (SGA). CONCLUSIONS: Maternal exposure to Cd during pregnancy was associated with decreased gestational age and increased likelihood of PTB.
Authors: Juliana Stone; Pragna Sutrave; Emily Gascoigne; Matthew B Givens; Rebecca C Fry; Tracy A Manuck Journal: Am J Obstet Gynecol MFM Date: 2021-01-11
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Authors: Tracy A Manuck; Yunjia Lai; Hongyu Ru; Angelica V Glover; Julia E Rager; Rebecca C Fry; Kun Lu Journal: Am J Obstet Gynecol MFM Date: 2021-05-12
Authors: Stephani S Kim; John D Meeker; Alexander P Keil; Max T Aung; Paige A Bommarito; David E Cantonwine; Thomas F McElrath; Kelly K Ferguson Journal: Environ Res Date: 2019-10-24 Impact factor: 8.431