| Literature DB >> 27273631 |
Ilia G Denisov1, Stephen G Sligar1,2.
Abstract
Membrane proteins have long presented a challenge to biochemical and functional studies. In the absence of a bilayer environment, individual proteins and critical macromolecular complexes may be insoluble and may display altered or absent activities. Nanodisc technology provides important advantages for the isolation, purification, structural resolution and functional characterization of membrane proteins. In addition, the ability to precisely control the nanodisc composition provides a nanoscale membrane surface for investigating molecular recognition events.Entities:
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Year: 2016 PMID： 27273631 PMCID： PMC8934039 DOI： 10.1038/nsmb.3195
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369