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Literature DB >> 2726449

New tandem repeat region in the non-transcribed spacer of human ribosomal RNA gene.

Abstract

A new repetitive DNA region was identified in the non-transcribed spacer of human rDNA, namely a long (4.6 kb) sequence motif (Xbal element) was present in two copies. The repeating unit composed of two parts. One of them consisted of unique nucleotide sequences, interrupted by some simple sequences. The other, about 3.1 kb long one assembled only from highly repeated simple sequences. The unique sequence region contained two, inverted copies of the human AluI type repetitive DNA family. The authors suggest that the XbaI elements may flank the tandem arrays of human rRNA genes as terminal repeats and they might function both as the origin of rDNA replication and/or site of homologous recombination.

Entities: Gene Species

Mesh：

Substances：
DNA, Ribosomal

Year: 1989 PMID： 2726449 PMCID： PMC317709 DOI： 10.1093/nar/17.8.3013

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

37 in total

1. ATP stimulates the binding of simian virus 40 (SV40) large tumor antigen to the SV40 origin of replication.

Authors: J A Borowiec; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1988-01 Impact factor: 11.205

2. The ribosomal spacer in Xenopus laevis is transcribed as part of the primary ribosomal RNA.

Authors: R F De Winter; T Moss
Journal: Nucleic Acids Res Date: 1986-08-11 Impact factor: 16.971

3. A transcriptional terminator is a novel element of the promoter of the mouse ribosomal RNA gene.

Authors: S Henderson; B Sollner-Webb
Journal: Cell Date: 1986-12-26 Impact factor: 41.582

Review 4. Transcription of cloned eukaryotic ribosomal RNA genes.

Authors: B Sollner-Webb; J Tower
Journal: Annu Rev Biochem Date: 1986 Impact factor: 23.643

5. Characterization of rat ribosomal DNA. The highly repetitive sequences that flank the ribosomal RNA transcription unit are homologous and contain RNA polymerase III transcription initiation sites.

Authors: D L Mroczka; B Cassidy; H Busch; L I Rothblum
Journal: J Mol Biol Date: 1984-03-25 Impact factor: 5.469

6. Length heterogeneity in a region of the human ribosomal gene spacer is not accompanied by extensive population polymorphism.

Authors: M Krystal; N Arnheim
Journal: J Mol Biol Date: 1978-11-25 Impact factor: 5.469

7. Evolutionary divergence of promoters and spacers in the rDNA family of four Drosophila species. Implications for molecular coevolution in multigene families.

Authors: D Tautz; C Tautz; D Webb; G A Dover
Journal: J Mol Biol Date: 1987-06-05 Impact factor: 5.469

8. A membrane-filter technique for the detection of complementary DNA.

Authors: D T Denhardt
Journal: Biochem Biophys Res Commun Date: 1966-06-13 Impact factor: 3.575

9. Human ribosomal RNA gene spacer sequences are found interspersed elsewhere in the genome.

Authors: R Higuchi; H D Stang; J K Browne; M O Martin; M Huot; J Lipeles; W Salser
Journal: Gene Date: 1981-11 Impact factor: 3.688

10. Nucleotide sequence analysis of the spacer regions flanking the rat rRNA transcription unit and identification of repetitive elements.

Authors: L P Yavachev; O I Georgiev; E A Braga; T A Avdonina; A E Bogomolova; V B Zhurkin; V V Nosikov; A A Hadjiolov
Journal: Nucleic Acids Res Date: 1986-03-25 Impact factor: 16.971

7 in total

New tandem repeat region in the non-transcribed spacer of human ribosomal RNA gene.

1. ATP stimulates the binding of simian virus 40 (SV40) large tumor antigen to the SV40 origin of replication.

2. The ribosomal spacer in Xenopus laevis is transcribed as part of the primary ribosomal RNA.

3. A transcriptional terminator is a novel element of the promoter of the mouse ribosomal RNA gene.

Review 4. Transcription of cloned eukaryotic ribosomal RNA genes.

5. Characterization of rat ribosomal DNA. The highly repetitive sequences that flank the ribosomal RNA transcription unit are homologous and contain RNA polymerase III transcription initiation sites.

6. Length heterogeneity in a region of the human ribosomal gene spacer is not accompanied by extensive population polymorphism.

7. Evolutionary divergence of promoters and spacers in the rDNA family of four Drosophila species. Implications for molecular coevolution in multigene families.

8. A membrane-filter technique for the detection of complementary DNA.

9. Human ribosomal RNA gene spacer sequences are found interspersed elsewhere in the genome.

10. Nucleotide sequence analysis of the spacer regions flanking the rat rRNA transcription unit and identification of repetitive elements.

1. Human ribosomal RNA intergenic spacer sequence.

2. Retroposons do jump: a B2 element recently integrated in an 18S rDNA gene.

3. Tandem repeats in extrachromosomal ribosomal DNA of Dictyostelium discoideum, resulting from chromosomal mutations.

4. Medium reiteration frequency repetitive sequences in the human genome.

5. Initiation and termination of DNA replication in human rRNA genes.

6. Mapping of replication initiation sites in human ribosomal DNA by nascent-strand abundance analysis.

7. Active RNA polymerase I is fixed within the nucleus of HeLa cells.