Literature DB >> 2725826

Increased choline acetyltransferase activity by Chinese herbal medicine Sho-saiko-to-go-keishi-ka-shakuyaku-to in aged rat brain.

M Hiramatsu1, K Haba, R Edamatsu, H Hamada, A Mori.   

Abstract

The effect of a Chinese herbal medicine Sho-saiko-to-go-keishi-ka-shakuyaku-to (TJ-960) on the brain choline acetyltransferase (CAT) activity was studied in adult (3.5 months of age) and aged (24 months of age) rats. After oral administration of 5% TJ-960 solution for 3 months, CAT activity in the hippocampus, pons-medulla oblongata and striatum of aged rats was significantly lower than that of adult rats. CAT activity in the cerebellum, however, was significantly higher in the aged rats, as compared to the adult rats. TJ-960 significantly increased CAT activity in the hippocampus and striatum of aged rats, but did not affect the activity of the enzyme in the adult rat brain.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2725826     DOI： 10.1007/bf00971319

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  7 in total

1.  A rapid radiochemical method for the determination of choline acetyltransferase.

Authors:  F Fonnum
Journal:  J Neurochem       Date:  1975-02       Impact factor: 5.372

2.  The possible involvement of free radicals in seizure mechanism.

Authors:  M Hiramatsu; R Edamatsu; M Kohno; A Mori
Journal:  Jpn J Psychiatry Neurol       Date:  1986-09

3.  Inhibitory effect of a mixture of herbal drugs (TJ-960, SK) on pentylenetetrazol-induced convulsions in E1 mice.

Authors:  E Sugaya; A Ishige; K Sekiguchi; S Iizuka; A Sugimoto; M Yuzurihara; E Hosoya
Journal:  Epilepsy Res       Date:  1988 Sep-Oct       Impact factor: 3.045

4.  Biochemical evidence of selective nerve cell changes in the normal ageing human and rat brain.

Authors:  S J Allen; J S Benton; M J Goodhardt; E A Haan; N R Sims; C C Smith; J A Spillane; D M Bowen; A N Davison
Journal:  J Neurochem       Date:  1983-07       Impact factor: 5.372

5.  A method for parallel determination of choline acetyltransferase and muscarinic cholinergic receptors: application in aged-rat brain.

Authors:  K Haba; N Ogawa; M Kawata; A Mori
Journal:  Neurochem Res       Date:  1988-10       Impact factor: 3.996

6.  Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.

Authors:  J Glowinski; L L Iversen
Journal:  J Neurochem       Date:  1966-08       Impact factor: 5.372

7.  Production of [14C]acetylcholine and [14C]carbon dioxide from [U-14C]glucose in tissue prisms from aging rat brain.

Authors:  N R Sims; K L Marek; D M Bowen; A N Davison
Journal:  J Neurochem       Date:  1982-02       Impact factor: 5.372
  7 in total
  3 in total

1.  Free radical scavenging activity of the Japanese herbal medicine toki-shakuyaku-san (TJ-23) and its effect on superoxide dismutase activity, lipid peroxides, glutamate, and monoamine metabolites in aged rat brain.

Authors:  Y Ueda; M Komatsu; M Hiramatsu
Journal:  Neurochem Res       Date:  1996-08       Impact factor: 3.996

2.  Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse.

Authors:  Y Kondo; F Kondo; M Asanuma; K Tanaka; N Ogawa
Journal:  Neurochem Res       Date:  2000-02       Impact factor: 3.996

3.  Age-related increases in superoxide dismutase activity and thiobarbituric acid-reactive substances: effect of bio-catalyzer in aged rat brain.

Authors:  L A Santiago; J A Osato; J Liu; A Mori
Journal:  Neurochem Res       Date:  1993-06       Impact factor: 3.996
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.