Eunjoo Yoo1, Chungkwon Yoo1, Tae-Eun Lee2, Yong Yeon Kim3. 1. Department of Ophthalmology, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul, 08308, South Korea. 2. Department of Ophthalmology, Chonbuk National University Medical School and Hospital, Jeonju, South Korea. 3. Department of Ophthalmology, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul, 08308, South Korea. yongykim@korea.ac.kr.
Abstract
PURPOSE: To investigate retinal vessel diameter in patients classified as bilateral glaucoma suspects who showed unilateral glaucomatous conversion. METHODS: This retrospective study included 21 patients who had initially been diagnosed as bilateral glaucoma suspects but showed unilateral glaucomatous conversion during a follow-up period of more than 2 years. Conversion to glaucoma was determined either by documentation of a new retinal nerve fiber layer defect on red-free photography or a reproducible glaucomatous visual field defect. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured from fundus photographs taken at baseline and at the point of glaucoma conversion. RESULTS: The mean CRAE of the converted eyes was significantly lower than that of the non-converted eyes at baseline (164.9 ± 13.2 μm vs 175.2 ± 15.6 μm; p = 0.001), but no significant difference was observed in the mean CRVE (p = 0.108). The mean CRAE of the converted eyes was also lower than in the non-converted eyes at the point of glaucoma conversion (158.6 ± 13.5 μm vs 168.0 ± 17.2 μm; p = 0.011). CONCLUSION: In bilateral glaucoma suspects, there was a significant inter-eye difference in CRAE at baseline between eyes that converted to glaucoma and those that did not. These findings suggest that measurement of retinal arteriolar diameter may help clinicians when evaluating the risk of conversion in glaucoma suspects.
PURPOSE: To investigate retinal vessel diameter in patients classified as bilateral glaucoma suspects who showed unilateral glaucomatous conversion. METHODS: This retrospective study included 21 patients who had initially been diagnosed as bilateral glaucoma suspects but showed unilateral glaucomatous conversion during a follow-up period of more than 2 years. Conversion to glaucoma was determined either by documentation of a new retinal nerve fiber layer defect on red-free photography or a reproducible glaucomatous visual field defect. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured from fundus photographs taken at baseline and at the point of glaucoma conversion. RESULTS: The mean CRAE of the converted eyes was significantly lower than that of the non-converted eyes at baseline (164.9 ± 13.2 μm vs 175.2 ± 15.6 μm; p = 0.001), but no significant difference was observed in the mean CRVE (p = 0.108). The mean CRAE of the converted eyes was also lower than in the non-converted eyes at the point of glaucoma conversion (158.6 ± 13.5 μm vs 168.0 ± 17.2 μm; p = 0.011). CONCLUSION: In bilateral glaucoma suspects, there was a significant inter-eye difference in CRAE at baseline between eyes that converted to glaucoma and those that did not. These findings suggest that measurement of retinal arteriolar diameter may help clinicians when evaluating the risk of conversion in glaucoma suspects.
Entities:
Keywords:
Central retinal arteriolar equivalent; Central retinal venular equivalent; Glaucoma suspect; Retinal vessel diameter; Unilateral glaucomatous conversion
Authors: Lauren M Sherry; Jie Jin Wang; Elena Rochtchina; TienY Wong; Ronald Klein; LarryD Hubbard; Paul Mitchell Journal: Clin Exp Ophthalmol Date: 2002-06 Impact factor: 4.207
Authors: Maziar Lalezary; Felipe A Medeiros; Robert N Weinreb; Christopher Bowd; Pamela A Sample; Ivan M Tavares; Ali Tafreshi; Linda M Zangwill Journal: Am J Ophthalmol Date: 2006-10 Impact factor: 5.258
Authors: Kerri P Howard; Barbara E K Klein; Jennifer O Dreyer; Lorraine G Danforth; Ronald Klein Journal: JAMA Ophthalmol Date: 2014-01 Impact factor: 7.389
Authors: A R Sharrett; L D Hubbard; L S Cooper; P D Sorlie; R J Brothers; F J Nieto; J L Pinsky; R Klein Journal: Am J Epidemiol Date: 1999-08-01 Impact factor: 4.897