PURPOSE: To determine whether retrobulbar blood flow (RBF) velocities are predictive of conversion to glaucoma. METHODS: A total of 262 glaucoma suspects were prospectively selected. Participants had normal visual field, increased intraocular pressure, and glaucomatous optic disc appearance at baseline. Topographic analysis of the optic nerve head was performed using a confocal laser scanning ophthalmoscope and the blood flow velocity of retrobulbar vessels was measured by color Doppler imaging. Conversion to glaucoma was assessed according to the changes in the color-coded Moorfields Regression Analysis (MRA) classification of the confocal laser scanning system during a 48-month follow-up period. Survival curves and hazard ratios (HRs) for the association between RBF parameters and conversion to glaucoma were calculated. RESULTS: End-diastolic velocity and mean velocity in the ophthalmic artery were reduced in subjects that converted to glaucoma based on MRA (36 individuals, 13.7%), while resistivity (RI) and pulsatility indices were increased in the same vessel. Patients with RI values lower than 0.75 in the ophthalmic artery had a survival rate (MRA-converters versus nonconverters) of 93.9%, whereas individuals with RI values greater than 0.75 had a survival rate of 81.7% (HR = 3.306; P = 0.002). CONCLUSIONS: Abnormal RBF velocities measured by color Doppler ultrasound may be a risk factor for conversion to glaucoma. An RI value higher than 0.75 in the ophthalmic artery was associated with the development of glaucoma.
PURPOSE: To determine whether retrobulbar blood flow (RBF) velocities are predictive of conversion to glaucoma. METHODS: A total of 262 glaucoma suspects were prospectively selected. Participants had normal visual field, increased intraocular pressure, and glaucomatous optic disc appearance at baseline. Topographic analysis of the optic nerve head was performed using a confocal laser scanning ophthalmoscope and the blood flow velocity of retrobulbar vessels was measured by color Doppler imaging. Conversion to glaucoma was assessed according to the changes in the color-coded Moorfields Regression Analysis (MRA) classification of the confocal laser scanning system during a 48-month follow-up period. Survival curves and hazard ratios (HRs) for the association between RBF parameters and conversion to glaucoma were calculated. RESULTS: End-diastolic velocity and mean velocity in the ophthalmic artery were reduced in subjects that converted to glaucoma based on MRA (36 individuals, 13.7%), while resistivity (RI) and pulsatility indices were increased in the same vessel. Patients with RI values lower than 0.75 in the ophthalmic artery had a survival rate (MRA-converters versus nonconverters) of 93.9%, whereas individuals with RI values greater than 0.75 had a survival rate of 81.7% (HR = 3.306; P = 0.002). CONCLUSIONS: Abnormal RBF velocities measured by color Doppler ultrasound may be a risk factor for conversion to glaucoma. An RI value higher than 0.75 in the ophthalmic artery was associated with the development of glaucoma.
Authors: Antonio Ferreras; Luís E Pablo; David F Garway-Heath; Paolo Fogagnolo; Julián García-Feijoo Journal: Invest Ophthalmol Vis Sci Date: 2008-03-31 Impact factor: 4.799
Authors: D S Kamal; A C Viswanathan; D F Garway-Heath; R A Hitchings; D Poinoosawmy; C Bunce Journal: Br J Ophthalmol Date: 1999-03 Impact factor: 4.638
Authors: Christopher Kai Shun Leung; Shu Liu; Robert N Weinreb; Gilda Lai; Cong Ye; Carol Yim Lui Cheung; Chi Pui Pang; Kwok Kay Tse; Dennis Shun Chiu Lam Journal: Ophthalmology Date: 2011-04-29 Impact factor: 12.079
Authors: Brent Siesky; Alon Harris; Joseph Carr; Alice Verticchio Vercellin; Rehan M Hussain; Priyanka Parekh Hembree; Scott Wentz; Michael Isaacs; George Eckert; Nicholas A Moore Journal: J Glaucoma Date: 2016-09 Impact factor: 2.503
Authors: Alon Harris; Giovanna Guidoboni; Brent Siesky; Sunu Mathew; Alice C Verticchio Vercellin; Lucas Rowe; Julia Arciero Journal: Prog Retin Eye Res Date: 2020-01-24 Impact factor: 21.198
Authors: Fatima Jimenez-Aragon; Elena Garcia-Martin; Raquel Larrosa-Lopez; Jose M Artigas-Martín; Pilar Seral-Moral; Luis E Pablo Journal: Biomed Res Int Date: 2013-09-17 Impact factor: 3.411
Authors: Magdalena Asejczyk-Widlicka; Patrycja Krzyzanowska-Berkowska; Beata P Sander; D Robert Iskander Journal: PLoS One Date: 2015-07-28 Impact factor: 3.240