J Noelting1, J E Eaton1, R S Choung1, A R Zinsmeister2, G R Locke1, A E Bharucha3. 1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. 2. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. 3. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. bharucha.adil@mayo.edu.
Abstract
BACKGROUND: Defecatory disorders (DD) are defined by clinical and objective features of impaired rectal evacuation. The epidemiology of DD in the population is unknown, partly because many constipated patients do not undergo anorectal tests. Our objectives were to estimate the incidence rate and clinical features of DD in the community. METHODS: We reviewed the medical records of all patients older than 16 years in Olmsted County, MN, who had constipation and underwent anorectal manometry from 1999 through 2008. Criteria for diagnosing DD were constipation for 6 months or longer and one of the following: (i) abnormal rectal balloon expulsion test; (ii) reduced or increased perineal descent; or (iii) two or more abnormal features with defecography or surface electromyography. KEY RESULTS: Of 11 112 constipated patients, 516 had undergone anorectal tests; 245 of these (209 women, 36 men) had a DD. The mean (±SD) age at diagnosis was 44 years (±18) among women and 49 years (±19) among men. The overall age- and sex-adjusted incidence rate per 100 000 person-years was 19.3 (95% CI: 16.8-21.8). The age-adjusted incidence per 100 000 person-years was greater (p < 0.0001) in women (31.8, 95% CI: 27.4-36.1) than in men (6.6, 95% CI: 4.4-8.9). Prior to the diagnosis of DD, nearly 30% of patients had irritable bowel syndrome (IBS), 48% had a psychiatric diagnosis, 18% had a history of abuse, and 21% reported urinary and/or fecal incontinence. CONCLUSIONS & INFERENCES: Among constipated patients, DD are fourfold more common in women than men and often associated with IBS and psychiatric diagnoses.
BACKGROUND:Defecatory disorders (DD) are defined by clinical and objective features of impaired rectal evacuation. The epidemiology of DD in the population is unknown, partly because many constipatedpatients do not undergo anorectal tests. Our objectives were to estimate the incidence rate and clinical features of DD in the community. METHODS: We reviewed the medical records of all patients older than 16 years in Olmsted County, MN, who had constipation and underwent anorectal manometry from 1999 through 2008. Criteria for diagnosing DD were constipation for 6 months or longer and one of the following: (i) abnormal rectal balloon expulsion test; (ii) reduced or increased perineal descent; or (iii) two or more abnormal features with defecography or surface electromyography. KEY RESULTS: Of 11 112 constipatedpatients, 516 had undergone anorectal tests; 245 of these (209 women, 36 men) had a DD. The mean (±SD) age at diagnosis was 44 years (±18) among women and 49 years (±19) among men. The overall age- and sex-adjusted incidence rate per 100 000 person-years was 19.3 (95% CI: 16.8-21.8). The age-adjusted incidence per 100 000 person-years was greater (p < 0.0001) in women (31.8, 95% CI: 27.4-36.1) than in men (6.6, 95% CI: 4.4-8.9). Prior to the diagnosis of DD, nearly 30% of patients had irritable bowel syndrome (IBS), 48% had a psychiatric diagnosis, 18% had a history of abuse, and 21% reported urinary and/or fecal incontinence. CONCLUSIONS & INFERENCES: Among constipatedpatients, DD are fourfold more common in women than men and often associated with IBS and psychiatric diagnoses.
Authors: Satish S C Rao; Jessica Valestin; C Kice Brown; Bridget Zimmerman; Konrad Schulze Journal: Am J Gastroenterol Date: 2010-02-23 Impact factor: 10.864
Authors: Shiva K Ratuapli; Adil E Bharucha; Jessica Noelting; Doris M Harvey; Alan R Zinsmeister Journal: Gastroenterology Date: 2012-11-07 Impact factor: 22.682
Authors: Giuseppe Chiarioni; Sung Min Kim; Italo Vantini; William E Whitehead Journal: Clin Gastroenterol Hepatol Date: 2014-03-24 Impact factor: 11.382
Authors: Subhankar Chakraborty; Kelly Feuerhak; Anjani Muthyala; William S Harmsen; Kent R Bailey; Adil E Bharucha Journal: Clin Gastroenterol Hepatol Date: 2018-08-18 Impact factor: 11.382
Authors: Anjani Muthyala; Kelly J Feuerhak; William S Harmsen; Subhankar Chakraborty; Kent R Bailey; Adil E Bharucha Journal: Neurogastroenterol Motil Date: 2019-04-29 Impact factor: 3.598
Authors: Emma V Carrington; S Mark Scott; Adil Bharucha; François Mion; Jose M Remes-Troche; Allison Malcolm; Henriette Heinrich; Mark Fox; Satish S Rao Journal: Nat Rev Gastroenterol Hepatol Date: 2018-04-11 Impact factor: 46.802