| Literature DB >> 2724305 |
B M Degnan1, C J Hawkins, M F Lavin, E J McCaffrey, D L Parry, A L van den Brenk, D J Watters.
Abstract
The isolation and structures of a new patellamide (patellamide D) and two new lissoclinamides (lissoclinamides 4 and 5) from the aplousobranch ascidian Lissoclinum patella are described. Structures were determined largely by using two-dimensional NMR techniques and mass spectrometry. These peptides and other members of the patellamide and lissoclinamide families that have been reported previously are found within the obligate algal symbiont of the genus Prochloron. The cytotoxicities of the compounds toward fibroblast and tumor cell lines are reported. One of these compounds, lissoclinamide 4, is markedly more toxic than other members of the family. Structure-activity relationships are discussed.Entities:
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Year: 1989 PMID： 2724305 DOI： 10.1021/jm00126a034
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446