OBJECTIVE: Few studies have examined functional abilities and complaints in healthy older adults (HOAs) with subjective cognitive concerns (SCC). The aims of this study were to assess everyday functioning in HOAs reporting high and low amounts of SCC and examine cognitive correlates of functional abilities. METHOD: Twenty-six HOAs with high SCC and 25 HOAs with low SCC, as well as their knowledgeable informants, completed the Instrumental Activities of Daily Living-Compensation (IADL-C), a questionnaire measure of everyday functioning. RESULTS: After controlling for depression, the high-SCC group self-reported significantly more everyday difficulties on the IADL-C, including all subdomains. Compared to the low-SCC group, informants for the high-SCC group endorsed more difficulties on the IADL-C and specifically the social skills subdomain. For the high-SCC group, poorer self-report of everyday functioning was related to poorer executive functioning and temporal order memory. CONCLUSIONS: These findings indicate that there may be subtle functional changes that occur early in the spectrum of cognitive decline in individuals with high SCC, and these functional changes are evident to informants. Further work is needed to investigate whether individuals with both SCC and functional difficulties are at an even higher risk for progression to mild cognitive impairment.
OBJECTIVE: Few studies have examined functional abilities and complaints in healthy older adults (HOAs) with subjective cognitive concerns (SCC). The aims of this study were to assess everyday functioning in HOAs reporting high and low amounts of SCC and examine cognitive correlates of functional abilities. METHOD: Twenty-six HOAs with high SCC and 25 HOAs with low SCC, as well as their knowledgeable informants, completed the Instrumental Activities of Daily Living-Compensation (IADL-C), a questionnaire measure of everyday functioning. RESULTS: After controlling for depression, the high-SCC group self-reported significantly more everyday difficulties on the IADL-C, including all subdomains. Compared to the low-SCC group, informants for the high-SCC group endorsed more difficulties on the IADL-C and specifically the social skills subdomain. For the high-SCC group, poorer self-report of everyday functioning was related to poorer executive functioning and temporal order memory. CONCLUSIONS: These findings indicate that there may be subtle functional changes that occur early in the spectrum of cognitive decline in individuals with high SCC, and these functional changes are evident to informants. Further work is needed to investigate whether individuals with both SCC and functional difficulties are at an even higher risk for progression to mild cognitive impairment.
Authors: Katherine E Nutter-Upham; Andrew J Saykin; Laura A Rabin; Robert M Roth; Heather A Wishart; Nadia Pare; Laura A Flashman Journal: Arch Clin Neuropsychol Date: 2008-03-12 Impact factor: 2.813
Authors: S A M Sikkes; E S M de Lange-de Klerk; Y A L Pijnenburg; P Scheltens; B M J Uitdehaag Journal: J Neurol Neurosurg Psychiatry Date: 2009-01 Impact factor: 10.154
Authors: Melissa T Buelow; Geoffrey Tremont; Laura L Frakey; Janet Grace; Brian R Ott Journal: Am J Alzheimers Dis Other Demen Date: 2014-06-13 Impact factor: 2.035
Authors: Steven Paul Woods; Michael Weinborn; Aimee Velnoweth; Alexandra Rooney; Romola S Bucks Journal: J Int Neuropsychol Soc Date: 2011-10-28 Impact factor: 2.892
Authors: Laura A Rabin; Andrew J Saykin; John D West; Marlana J Borgos; Heather A Wishart; Katherine E Nutter-Upham; Laura A Flashman; Robert B Santulli Journal: Brain Imaging Behav Date: 2009-06 Impact factor: 3.978
Authors: Sarah Tomaszewski Farias; Tania Giovannetti; Brennan R Payne; Michael Marsiske; George W Rebok; K Warner Schaie; Kelsey R Thomas; Sherry L Willis; Joseph M Dzierzewski; Frederick Unverzagt; Alden L Gross Journal: J Int Neuropsychol Soc Date: 2017-08-11 Impact factor: 2.892
Authors: Jennifer L Thompson; David P Sheppard; Anastasia Matchanova; Erin E Morgan; Shayne Loft; Steven Paul Woods Journal: Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Date: 2022-04-12
Authors: David P Sheppard; Matthew W Gallagher; Erin E Morgan; Angulique Y Outlaw; Sylvie Naar; Steven Paul Woods Journal: J Int Neuropsychol Soc Date: 2021-05-06 Impact factor: 3.114
Authors: Brenna Cholerton; Kathleen L Poston; Lu Tian; Joseph F Quinn; Kathryn A Chung; Amie L Hiller; Shu-Ching Hu; Krista Specketer; Thomas J Montine; Karen L Edwards; Cyrus P Zabetian Journal: Mov Disord Clin Pract Date: 2019-12-14
Authors: Kristen M George; Rachel L Peterson; Paola Gilsanz; Dan M Mungas; M Maria Glymour; Elizabeth Rose Mayeda; Rachel A Whitmer Journal: Ethn Dis Date: 2020-07-09 Impact factor: 1.847
Authors: Linda H G Pagen; Benedikt A Poser; Martin P J van Boxtel; Nikos Priovoulos; Roy W E van Hooren; Frans R J Verhey; Heidi I L Jacobs Journal: Brain Sci Date: 2022-03-12