| Literature DB >> 27235797 |
Jo-Anne Bright1, Duncan Taylor2, Catherine McGovern3, Stuart Cooper3, Laura Russell3, Damien Abarno4, John Buckleton3.
Abstract
In 2015 the Scientific Working Group on DNA Analysis Methods published the SWGDAM Guidelines for the Validation of Probabilistic Genotyping Systems [1]. STRmix™ is probabilistic genotyping software that employs a continuous model of DNA profile interpretation. This paper describes the developmental validation activities of STRmix™ following the SWGDAM guidelines. It addresses the underlying scientific principles, and the performance of the models with respect to sensitivity, specificity and precision and results of interpretation of casework type samples. This work demonstrates that STRmix™ is suitable for its intended use for the interpretation of single source and mixed DNA profiles.Keywords: Continuous method; DNA mixtures; Probabilistic genotyping; STRmix; Validation
Mesh：
Year: 2016 PMID： 27235797 DOI： 10.1016/j.fsigen.2016.05.007
Source DB: PubMed Journal: Forensic Sci Int Genet ISSN： 1872-4973 Impact factor: 4.882