Current developments in toxicology.



As already previously reported the EXCLI Journal closely cooperates with the Archives of Toxicology as a partner for articles focussing on basic and clinical research (Bolt, 2011[7]; Bolt and Stewart, 2011[9]). To give our readers an overview over current cutting-edge topics in toxicology we publish a compilation of brief ‘key messages’ from the most cited articles (Table 1(Tab. 1)). (References in Table 1: Bolt et al., 2012[8]; Kell, 2010[30]; Pestka, 2010[45]; Adler et al., 2011[1]; Xie et al., 2010[68]; Drobná et al., 2010[14]; Valdiglesias et al., 2010[62]; Foldbjerg et al., 2011[19]; Mamas et al., 2011[38]; Brozmanová et al., 2010[11]; Elcombe et al., 2010[18]; Nielsen and Wolkoff, 2010[41]; Rand et al., 2010[47]; Nogueira and Rocha, 2011[43]; Baird and Dinkova-Kostava, 2011[4]; Slocum and Kensler, 2011[58]; Druwe and Vaillancourt, 2010[15]; Prigol et al., 2010[46]; Sriram et al., 2010[59]; van Berlo et al., 2010[63]; Read et al., 2010[48]; Kirsch-Volders et al., 2011[32]; Wobus and Löser, 2011[67]; Bakhiya and Appel, 2010[5]; Kawai et al., 2010[29]; Marano et al., 2011[39]; Wagner et al., 2010[64]; Al-Rawi et al., 2011[2]; Lehmann et al., 2010[34]; Wang et al., 2010[65]; Hoshino et al., 2011[26]; Rodrigues et al., 2010[50]; Liu et al., 2010[37]; Audebert et al., 2011[3]; Wang et al., 2011[66]; Barcelos et al., 2011[6]; Clift et al., 2011[13]; Kim et al., 2011[31]; Yen et al., 2011[69]; Yun et al., 2010[71]; Sinicropi et al., 2010[57]; Bosetti et al., 2010[10]; Repetto et al., 2010[49]; Nishimura et al., 2010[42]; Jeong et al., 2010[27]; Calabrese, 2011[12]; Heng et al., 2011[24]; Park et al., 2011[44]; Shimamoto et al., 2011[56]; Rossato et al., 2011[53]; Gehrke et al., 2011[20]; Gibson et al., 2011[21]; Golka et al., 2011[22]; Durner et al., 2011[16]; Tripathi et al., 2010[60]; Haarmann-Stemmann et al., 2010[23]; Höfer et al., 2010[25]; Romano et al., 2010[51]; Shimada et al., 2010[55]; Liu et al., 2010[36]; Karp and Caspi, 2011[28]; Zhao et al., 2011[72]; Leppänen et al., 2011[35]; Truong et al., 2011[61]; Heng et al., 2011[24]; Mielke et al., 2011[40]; Yu et al., 2011[70]; Serpeloni et al., 2010[54]; Romero et al., 2010[52]; Klaric et al., 2010[33]; El-Agamy, 2010[17]) The citation ranking illustrates that research on nanoparticles has evolved to the currently most studied field in toxicology (Xie et al., 2010[68]; Foldbjerg et al., 2011[19]). As in the previous years oxidative stress research remains a cutting-edge topic (Kell, 2010[30]). Clearly, alternative methods of toxicity testing represent an emerging field of research. This development was further intensified by the 7th amendment to the EU Cosmetics Directive that prohibits to put animal-tested cosmetics on the market after 2013 (Adler et al., 2011[1]). Although this directive has been controversely discussed it has nevertheless initiated intensive research activities to establish novel in vitro tests. The review of Adler and colleagues (2011[1]) gives a comprehensive analysis of the current status of alternative methods and of the time necessary to achieve full replacement of animal testing.

Table 1

Key messages of the most cited articles in Archives of Toxicology (2010-2011)

(from: Bolt et al., 2012)