Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond.

Literature DB >> 27221566

Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond.

Triin Laisk-Podar¹, Cecilia M Lindgren², Maire Peters³, Juha S Tapanainen⁴, Cornelis B Lambalk⁵, Andres Salumets⁶, Reedik Mägi⁷.

Abstract

Ovarian function is central to female fertility, and several genome-wide association studies (GWAS) have been carried out to elucidate the genetic background of traits and disorders that reflect and affect ovarian physiology. While GWAS have been successful in reporting numerous genetic associations and highlighting involved pathways relevant to reproductive aging, for ovarian disorders, such as premature ovarian insufficiency and polycystic ovary syndrome, research has lagged behind due to insufficient study sample size. Novel approaches to study design and analysis methods that help to fit GWAS findings into biological context will improve our knowledge about genetics governing ovarian function in fertility and disease, and provide input for clinical tools and better patient management.

Entities: Chemical Disease Gene Mutation Species

Keywords: menopause; ovarian reserve; polycystic ovary syndrome; premature ovarian insufficiency

Mesh：

Year: 2016 PMID： 27221566 PMCID： PMC7610559 DOI： 10.1016/j.tem.2016.04.011

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

78 in total

Review 1. Five years of GWAS discovery.

Authors: Peter M Visscher; Matthew A Brown; Mark I McCarthy; Jian Yang
Journal: Am J Hum Genet Date: 2012-01-13 Impact factor: 11.025

2. Genome-wide association study of age at menarche in African-American women.

Authors: Ellen W Demerath; Ching-Ti Liu; Nora Franceschini; Gary Chen; Julie R Palmer; Erin N Smith; Christina T L Chen; Christine B Ambrosone; Alice M Arnold; Elisa V Bandera; Gerald S Berenson; Leslie Bernstein; Angela Britton; Anne R Cappola; Christopher S Carlson; Stephen J Chanock; Wei Chen; Zhao Chen; Sandra L Deming; Cathy E Elks; Michelle K Evans; Zofia Gajdos; Brian E Henderson; Jennifer J Hu; Sue Ingles; Esther M John; Kathleen F Kerr; Laurence N Kolonel; Loic Le Marchand; Xiaoning Lu; Robert C Millikan; Solomon K Musani; Nora L Nock; Kari North; Sarah Nyante; Michael F Press; Jorge L Rodriquez-Gil; Edward A Ruiz-Narvaez; Nicholas J Schork; Sathanur R Srinivasan; Nancy F Woods; Wei Zheng; Regina G Ziegler; Alan Zonderman; Gerardo Heiss; B Gwen Windham; Melissa Wellons; Sarah S Murray; Michael Nalls; Tomi Pastinen; Aleksandar Rajkovic; Joel Hirschhorn; L Adrienne Cupples; Charles Kooperberg; Joanne M Murabito; Christopher A Haiman
Journal: Hum Mol Genet Date: 2013-04-17 Impact factor: 6.150

3. Genome-wide analysis shows no genomic predictors of ovarian response to stimulation by exogenous FSH for IVF.

Authors: Jeroen van Disseldorp; Lude Franke; Rene Eijkemans; Frank Broekmans; Nick Macklon; Cisca Wijmenga; Bart Fauser
Journal: Reprod Biomed Online Date: 2010-12-23 Impact factor: 3.828

4. Analysis of multiple-cycle data from couples undergoing in vitro fertilization: methodologic issues and statistical approaches.

Authors: Stacey A Missmer; Kimberly R Pearson; Louise M Ryan; John D Meeker; Daniel W Cramer; Russ Hauser
Journal: Epidemiology Date: 2011-07 Impact factor: 4.822

5. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.

Authors: Zi-Jiang Chen; Han Zhao; Lin He; Yuhua Shi; Yingying Qin; Yongyong Shi; Zhiqiang Li; Li You; Junli Zhao; Jiayin Liu; Xiaoyan Liang; Xiaoming Zhao; Junzhao Zhao; Yingpu Sun; Bo Zhang; Hong Jiang; Dongni Zhao; Yuehong Bian; Xuan Gao; Ling Geng; Yiran Li; Dongyi Zhu; Xiuqin Sun; Jin-E Xu; Cuifang Hao; Chun-E Ren; Yajie Zhang; Shiling Chen; Wei Zhang; Aijun Yang; Junhao Yan; Yuan Li; Jinlong Ma; Yueran Zhao
Journal: Nat Genet Date: 2010-12-12 Impact factor: 38.330

6. A genome-wide linkage scan in a Dutch family identifies a premature ovarian failure susceptibility locus.

Authors: R A Oldenburg; M F van Dooren; B de Graaf; E Simons; L Govaerts; S Swagemakers; J M H Verkerk; B A Oostra; A M Bertoli-Avella
Journal: Hum Reprod Date: 2008-08-09 Impact factor: 6.918

7. Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes.

Authors: Katherine S Ruth; Purdey J Campbell; Shelby Chew; Ee Mun Lim; Narelle Hadlow; Bronwyn G A Stuckey; Suzanne J Brown; Bjarke Feenstra; John Joseph; Gabriela L Surdulescu; Hou Feng Zheng; J Brent Richards; Anna Murray; Tim D Spector; Scott G Wilson; John R B Perry
Journal: Eur J Hum Genet Date: 2015-05-27 Impact factor: 4.246

8. Identification of subjects with polycystic ovary syndrome using electronic health records.

Authors: Victor Castro; Yuanyuan Shen; Sheng Yu; Sean Finan; Cindy Ta Pau; Vivian Gainer; Candace C Keefe; Guergana Savova; Shawn N Murphy; Tianxi Cai; Corrine K Welt
Journal: Reprod Biol Endocrinol Date: 2015-10-29 Impact factor: 5.211

9. A genome-wide association study of early menopause and the combined impact of identified variants.

Authors: John R B Perry; Tanguy Corre; Tõnu Esko; Daniel I Chasman; Krista Fischer; Nora Franceschini; Chunyan He; Zoltan Kutalik; Massimo Mangino; Lynda M Rose; Albert Vernon Smith; Lisette Stolk; Patrick Sulem; Michael N Weedon; Wei V Zhuang; Alice Arnold; Alan Ashworth; Sven Bergmann; Julie E Buring; Andrea Burri; Constance Chen; Marilyn C Cornelis; David J Couper; Mark O Goodarzi; Vilmundur Gudnason; Tamara Harris; Albert Hofman; Michael Jones; Peter Kraft; Lenore Launer; Joop S E Laven; Guo Li; Barbara McKnight; Corrado Masciullo; Lili Milani; Nicholas Orr; Bruce M Psaty; Paul M Ridker; Fernando Rivadeneira; Cinzia Sala; Andres Salumets; Minouk Schoemaker; Michela Traglia; Gérard Waeber; Stephen J Chanock; Ellen W Demerath; Melissa Garcia; Susan E Hankinson; Frank B Hu; David J Hunter; Kathryn L Lunetta; Andres Metspalu; Grant W Montgomery; Joanne M Murabito; Anne B Newman; Ken K Ong; Tim D Spector; Kari Stefansson; Anthony J Swerdlow; Unnur Thorsteinsdottir; Rob M Van Dam; André G Uitterlinden; Jenny A Visser; Peter Vollenweider; Daniela Toniolo; Anna Murray
Journal: Hum Mol Genet Date: 2013-01-09 Impact factor: 6.150

10. Defining the role of common variation in the genomic and biological architecture of adult human height.

Authors: Andrew R Wood; Tonu Esko; Jian Yang; Sailaja Vedantam; Tune H Pers; Stefan Gustafsson; Audrey Y Chu; Karol Estrada; Jian'an Luan; Zoltán Kutalik; Najaf Amin; Martin L Buchkovich; Damien C Croteau-Chonka; Felix R Day; Yanan Duan; Tove Fall; Rudolf Fehrmann; Teresa Ferreira; Anne U Jackson; Juha Karjalainen; Ken Sin Lo; Adam E Locke; Reedik Mägi; Evelin Mihailov; Eleonora Porcu; Joshua C Randall; André Scherag; Anna A E Vinkhuyzen; Harm-Jan Westra; Thomas W Winkler; Tsegaselassie Workalemahu; Jing Hua Zhao; Devin Absher; Eva Albrecht; Denise Anderson; Jeffrey Baron; Marian Beekman; Ayse Demirkan; Georg B Ehret; Bjarke Feenstra; Mary F Feitosa; Krista Fischer; Ross M Fraser; Anuj Goel; Jian Gong; Anne E Justice; Stavroula Kanoni; Marcus E Kleber; Kati Kristiansson; Unhee Lim; Vaneet Lotay; Julian C Lui; Massimo Mangino; Irene Mateo Leach; Carolina Medina-Gomez; Michael A Nalls; Dale R Nyholt; Cameron D Palmer; Dorota Pasko; Sonali Pechlivanis; Inga Prokopenko; Janina S Ried; Stephan Ripke; Dmitry Shungin; Alena Stancáková; Rona J Strawbridge; Yun Ju Sung; Toshiko Tanaka; Alexander Teumer; Stella Trompet; Sander W van der Laan; Jessica van Setten; Jana V Van Vliet-Ostaptchouk; Zhaoming Wang; Loïc Yengo; Weihua Zhang; Uzma Afzal; Johan Arnlöv; Gillian M Arscott; Stefania Bandinelli; Amy Barrett; Claire Bellis; Amanda J Bennett; Christian Berne; Matthias Blüher; Jennifer L Bolton; Yvonne Böttcher; Heather A Boyd; Marcel Bruinenberg; Brendan M Buckley; Steven Buyske; Ida H Caspersen; Peter S Chines; Robert Clarke; Simone Claudi-Boehm; Matthew Cooper; E Warwick Daw; Pim A De Jong; Joris Deelen; Graciela Delgado; Josh C Denny; Rosalie Dhonukshe-Rutten; Maria Dimitriou; Alex S F Doney; Marcus Dörr; Niina Eklund; Elodie Eury; Lasse Folkersen; Melissa E Garcia; Frank Geller; Vilmantas Giedraitis; Alan S Go; Harald Grallert; Tanja B Grammer; Jürgen Gräßler; Henrik Grönberg; Lisette C P G M de Groot; Christopher J Groves; Jeffrey Haessler; Per Hall; Toomas Haller; Goran Hallmans; Anke Hannemann; Catharina A Hartman; Maija Hassinen; Caroline Hayward; Nancy L Heard-Costa; Quinta Helmer; Gibran Hemani; Anjali K Henders; Hans L Hillege; Mark A Hlatky; Wolfgang Hoffmann; Per Hoffmann; Oddgeir Holmen; Jeanine J Houwing-Duistermaat; Thomas Illig; Aaron Isaacs; Alan L James; Janina Jeff; Berit Johansen; Åsa Johansson; Jennifer Jolley; Thorhildur Juliusdottir; Juhani Junttila; Abel N Kho; Leena Kinnunen; Norman Klopp; Thomas Kocher; Wolfgang Kratzer; Peter Lichtner; Lars Lind; Jaana Lindström; Stéphane Lobbens; Mattias Lorentzon; Yingchang Lu; Valeriya Lyssenko; Patrik K E Magnusson; Anubha Mahajan; Marc Maillard; Wendy L McArdle; Colin A McKenzie; Stela McLachlan; Paul J McLaren; Cristina Menni; Sigrun Merger; Lili Milani; Alireza Moayyeri; Keri L Monda; Mario A Morken; Gabriele Müller; Martina Müller-Nurasyid; Arthur W Musk; Narisu Narisu; Matthias Nauck; Ilja M Nolte; Markus M Nöthen; Laticia Oozageer; Stefan Pilz; Nigel W Rayner; Frida Renstrom; Neil R Robertson; Lynda M Rose; Ronan Roussel; Serena Sanna; Hubert Scharnagl; Salome Scholtens; Fredrick R Schumacher; Heribert Schunkert; Robert A Scott; Joban Sehmi; Thomas Seufferlein; Jianxin Shi; Karri Silventoinen; Johannes H Smit; Albert Vernon Smith; Joanna Smolonska; Alice V Stanton; Kathleen Stirrups; David J Stott; Heather M Stringham; Johan Sundström; Morris A Swertz; Ann-Christine Syvänen; Bamidele O Tayo; Gudmar Thorleifsson; Jonathan P Tyrer; Suzanne van Dijk; Natasja M van Schoor; Nathalie van der Velde; Diana van Heemst; Floor V A van Oort; Sita H Vermeulen; Niek Verweij; Judith M Vonk; Lindsay L Waite; Melanie Waldenberger; Roman Wennauer; Lynne R Wilkens; Christina Willenborg; Tom Wilsgaard; Mary K Wojczynski; Andrew Wong; Alan F Wright; Qunyuan Zhang; Dominique Arveiler; Stephan J L Bakker; John Beilby; Richard N Bergman; Sven Bergmann; Reiner Biffar; John Blangero; Dorret I Boomsma; Stefan R Bornstein; Pascal Bovet; Paolo Brambilla; Morris J Brown; Harry Campbell; Mark J Caulfield; Aravinda Chakravarti; Rory Collins; Francis S Collins; Dana C Crawford; L Adrienne Cupples; John Danesh; Ulf de Faire; Hester M den Ruijter; Raimund Erbel; Jeanette Erdmann; Johan G Eriksson; Martin Farrall; Ele Ferrannini; Jean Ferrières; Ian Ford; Nita G Forouhi; Terrence Forrester; Ron T Gansevoort; Pablo V Gejman; Christian Gieger; Alain Golay; Omri Gottesman; Vilmundur Gudnason; Ulf Gyllensten; David W Haas; Alistair S Hall; Tamara B Harris; Andrew T Hattersley; Andrew C Heath; Christian Hengstenberg; Andrew A Hicks; Lucia A Hindorff; Aroon D Hingorani; Albert Hofman; G Kees Hovingh; Steve E Humphries; Steven C Hunt; Elina Hypponen; Kevin B Jacobs; Marjo-Riitta Jarvelin; Pekka Jousilahti; Antti M Jula; Jaakko Kaprio; John J P Kastelein; Manfred Kayser; Frank Kee; Sirkka M Keinanen-Kiukaanniemi; Lambertus A Kiemeney; Jaspal S Kooner; Charles Kooperberg; Seppo Koskinen; Peter Kovacs; Aldi T Kraja; Meena Kumari; Johanna Kuusisto; Timo A Lakka; Claudia Langenberg; Loic Le Marchand; Terho Lehtimäki; Sara Lupoli; Pamela A F Madden; Satu Männistö; Paolo Manunta; André Marette; Tara C Matise; Barbara McKnight; Thomas Meitinger; Frans L Moll; Grant W Montgomery; Andrew D Morris; Andrew P Morris; Jeffrey C Murray; Mari Nelis; Claes Ohlsson; Albertine J Oldehinkel; Ken K Ong; Willem H Ouwehand; Gerard Pasterkamp; Annette Peters; Peter P Pramstaller; Jackie F Price; Lu Qi; Olli T Raitakari; Tuomo Rankinen; D C Rao; Treva K Rice; Marylyn Ritchie; Igor Rudan; Veikko Salomaa; Nilesh J Samani; Jouko Saramies; Mark A Sarzynski; Peter E H Schwarz; Sylvain Sebert; Peter Sever; Alan R Shuldiner; Juha Sinisalo; Valgerdur Steinthorsdottir; Ronald P Stolk; Jean-Claude Tardif; Anke Tönjes; Angelo Tremblay; Elena Tremoli; Jarmo Virtamo; Marie-Claude Vohl; Philippe Amouyel; Folkert W Asselbergs; Themistocles L Assimes; Murielle Bochud; Bernhard O Boehm; Eric Boerwinkle; Erwin P Bottinger; Claude Bouchard; Stéphane Cauchi; John C Chambers; Stephen J Chanock; Richard S Cooper; Paul I W de Bakker; George Dedoussis; Luigi Ferrucci; Paul W Franks; Philippe Froguel; Leif C Groop; Christopher A Haiman; Anders Hamsten; M Geoffrey Hayes; Jennie Hui; David J Hunter; Kristian Hveem; J Wouter Jukema; Robert C Kaplan; Mika Kivimaki; Diana Kuh; Markku Laakso; Yongmei Liu; Nicholas G Martin; Winfried März; Mads Melbye; Susanne Moebus; Patricia B Munroe; Inger Njølstad; Ben A Oostra; Colin N A Palmer; Nancy L Pedersen; Markus Perola; Louis Pérusse; Ulrike Peters; Joseph E Powell; Chris Power; Thomas Quertermous; Rainer Rauramaa; Eva Reinmaa; Paul M Ridker; Fernando Rivadeneira; Jerome I Rotter; Timo E Saaristo; Danish Saleheen; David Schlessinger; P Eline Slagboom; Harold Snieder; Tim D Spector; Konstantin Strauch; Michael Stumvoll; Jaakko Tuomilehto; Matti Uusitupa; Pim van der Harst; Henry Völzke; Mark Walker; Nicholas J Wareham; Hugh Watkins; H-Erich Wichmann; James F Wilson; Pieter Zanen; Panos Deloukas; Iris M Heid; Cecilia M Lindgren; Karen L Mohlke; Elizabeth K Speliotes; Unnur Thorsteinsdottir; Inês Barroso; Caroline S Fox; Kari E North; David P Strachan; Jacques S Beckmann; Sonja I Berndt; Michael Boehnke; Ingrid B Borecki; Mark I McCarthy; Andres Metspalu; Kari Stefansson; André G Uitterlinden; Cornelia M van Duijn; Lude Franke; Cristen J Willer; Alkes L Price; Guillaume Lettre; Ruth J F Loos; Michael N Weedon; Erik Ingelsson; Jeffrey R O'Connell; Goncalo R Abecasis; Daniel I Chasman; Michael E Goddard; Peter M Visscher; Joel N Hirschhorn; Timothy M Frayling
Journal: Nat Genet Date: 2014-10-05 Impact factor: 38.330

5 in total

1. Effect of melatonin on the peripheral T lymphocyte cell cycle and levels of reactive oxygen species in patients with premature ovarian failure.

Authors: Yanmin Li; Hongli Liu; Jing Sun; Yipeng Tian; Changzhong Li
Journal: Exp Ther Med Date: 2016-10-21 Impact factor: 2.447

5. Temporal transcriptomic landscape of postnatal mouse ovaries reveals dynamic gene signatures associated with ovarian aging.

Authors: Zixue Zhou; Xi Yang; Yuncheng Pan; Lingyue Shang; Siyuan Chen; Jialin Yang; Li Jin; Feng Zhang; Yanhua Wu
Journal: Hum Mol Genet Date: 2021-10-13 Impact factor: 6.150