| Literature DB >> 21151128 |
Zi-Jiang Chen1, Han Zhao, Lin He, Yuhua Shi, Yingying Qin, Yongyong Shi, Zhiqiang Li, Li You, Junli Zhao, Jiayin Liu, Xiaoyan Liang, Xiaoming Zhao, Junzhao Zhao, Yingpu Sun, Bo Zhang, Hong Jiang, Dongni Zhao, Yuehong Bian, Xuan Gao, Ling Geng, Yiran Li, Dongyi Zhu, Xiuqin Sun, Jin-E Xu, Cuifang Hao, Chun-E Ren, Yajie Zhang, Shiling Chen, Wei Zhang, Aijun Yang, Junhao Yan, Yuan Li, Jinlong Ma, Yueran Zhao.
Abstract
Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P(meta) = 7.55 × 10⁻²¹, odds ratio (OR) 0.71); 2p21 (rs13429458, P(meta) = 1.73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.Entities:
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Year: 2010 PMID： 21151128 DOI： 10.1038/ng.732
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330