Literature DB >> 6819173

The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats.

D K Yue, M A Hanwell, P M Satchell, J R Turtle.   

Abstract

This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozotocin-induced diabetic rats. Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2-9 mo duration. It remains to be determined whether Sorbinil can prevent chronic diabetic neuropathy.

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Year:  1982        PMID： 6819173     DOI： 10.2337/diab.31.9.789

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  30 in total

Review 1.  Pathogenesis of diabetic nephropathy.

Authors:  Claudia van Dijk; Tomas Berl
Journal:  Rev Endocr Metab Disord       Date:  2004-08       Impact factor: 6.514

2.  Metabolism of the aldose reductase inhibitor ALO1567 in man.

Authors:  Y H Park; J E Hudson; R C Barker; B M York; R K Brazzell
Journal:  Br J Clin Pharmacol       Date:  1991-08       Impact factor: 4.335

3.  Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat.

Authors:  L B Dahlin; D R Archer; W G McLean
Journal:  Diabetologia       Date:  1987-06       Impact factor: 10.122

Review 4.  Diabetic neuropathies. Current concepts in prevention and treatment.

Authors:  J D Ward
Journal:  Drugs       Date:  1986-09       Impact factor: 9.546

5.  Clinical and neurophysiological studies with the aldose reductase inhibitor, sorbinil, in symptomatic diabetic neuropathy.

Authors:  I G Lewin; I A O'Brien; M H Morgan; R J Corrall
Journal:  Diabetologia       Date:  1984-06       Impact factor: 10.122

6.  The effect of sorbinil treatment on red cell sorbitol levels and clinical and electrophysiological parameters of diabetic neuropathy.

Authors:  J M Lehtinen; S K Hyvönen; M Uusitupa; E Puhakainen; T Halonen; H Kilpeläinen
Journal:  J Neurol       Date:  1986-06       Impact factor: 4.849

7.  Sorbitol metabolism in retina studied in vitro.

Authors:  P Naeser; S E Brolin; U J Eriksson
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1989       Impact factor: 3.117

8.  Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs.

Authors:  R L Engerman; T S Kern; M E Larson
Journal:  Diabetologia       Date:  1994-02       Impact factor: 10.122

9.  Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition.

Authors:  K R Gillon; J N Hawthorne; D R Tomlinson
Journal:  Diabetologia       Date:  1983-10       Impact factor: 10.122

10.  Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats.

Authors:  A L Carrington; C B Ettlinger; N A Calcutt; D R Tomlinson
Journal:  Diabetologia       Date:  1991-06       Impact factor: 10.122
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