Literature DB >> 6766909

Altering the course of cataracts in diabetic rats.

S Fukushi, L O Merola, J H Kinoshita.   

Abstract

A potent new aldose reductase (AR) inhibitor was effective in preventing cataractous changes in diabetic rats. Untreated diabetic rats developed early lens changes by 3 weeks and dense nuclear opacities by 6 to 9 weeks. In contrast, diabetic rats treated with the AR inhibitor showed no lens changes during the 5-month period of the experiment.

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Year:  1980        PMID： 6766909

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  11 in total

1.  Vascular adhesion protein-1 regulates leukocyte transmigration rate in the retina during diabetes.

Authors:  Kousuke Noda; Shintaro Nakao; Souska Zandi; Verena Engelstädter; Yukihiko Mashima; Ali Hafezi-Moghadam
Journal:  Exp Eye Res       Date:  2009-07-25       Impact factor: 3.467

2.  Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

Authors:  P A Craven; F R DeRubertis
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808

Review 3.  The effect of oxidants on biomembranes and cellular metabolism.

Authors:  S K Srivastava; N H Ansari; S Liu; A Izban; B Das; G Szabo; A Bhatnagar
Journal:  Mol Cell Biochem       Date:  1989 Nov 23-Dec 19       Impact factor: 3.396

4.  Diabetes-induced changes in cardiac beta-adrenoceptor responsiveness: effects of aldose reductase inhibition with ponalrestat.

Authors:  C E Austin; R Chess-Williams
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

5.  Sorbitol metabolism in retina studied in vitro.

Authors:  P Naeser; S E Brolin; U J Eriksson
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1989       Impact factor: 3.117

6.  NADPH-oxidising activity in lens and erythrocytes in diabetic and nondiabetic patients with cataract.

Authors:  M J Crabbe; A J Bron; C O Peckar; M Petchey; H H Ting; J Howard-Williams
Journal:  Br J Ophthalmol       Date:  1983-10       Impact factor: 4.638

7.  Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined with diabetes.

Authors:  E Cotlier
Journal:  Int Ophthalmol       Date:  1981-05       Impact factor: 2.031

8.  Effects of aldose reductase inhibition on the retina and health indices of streptozotocin-diabetic rats.

Authors:  W M Kozak; N A Marker; K K Elmer
Journal:  Doc Ophthalmol       Date:  1986       Impact factor: 2.379

9.  Effect of statil on kidney structure, function and polyol accumulation in diabetes mellitus.

Authors:  G Faiman; P Ganguly; A Mehta; J A Thliveris
Journal:  Mol Cell Biochem       Date:  1993-08-11       Impact factor: 3.396

Review 10.  Pharmacological treatment strategies in age-related cataracts.

Authors:  J J Harding
Journal:  Drugs Aging       Date:  1992 Jul-Aug       Impact factor: 3.923
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