Yaakov Stern1, Yian Gu2, Stephanie Cosentino2, Martina Azar2, Siobhan Lawless2, Oksana Tatarina2. 1. Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA. Electronic address: ys11@columbia.edu. 2. Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Abstract
INTRODUCTION: The Predictors study was designed to predict the length of time to major disease outcomes in Alzheimer's disease (AD) patients. Here, we describe the development of a new, Predictors 3, cohort. METHODS: Patients with prevalent or incident AD and individuals at-risk for developing AD were selected from the North Manhattan community and followed annually with instruments comparable to those used in the original two Predictors cohorts. RESULTS: The original Predictors cohorts were clinic based and racially/ethnically homogenous (94% white, 6% black; 3% Hispanic). In contrast, the 274 elders in this cohort are community-based and ethnically diverse (39% white, 40% black, 21% other; 78% Hispanic). Confirming previous observations, psychotic features were associated with poorer function and mental status and extrapyramidal signs with poorer function. DISCUSSION: This new cohort will allow us to test observations made in our original clinic-based cohorts in patients that may be more representative of the general community.
INTRODUCTION: The Predictors study was designed to predict the length of time to major disease outcomes in Alzheimer's disease (AD) patients. Here, we describe the development of a new, Predictors 3, cohort. METHODS:Patients with prevalent or incident AD and individuals at-risk for developing AD were selected from the North Manhattan community and followed annually with instruments comparable to those used in the original two Predictors cohorts. RESULTS: The original Predictors cohorts were clinic based and racially/ethnically homogenous (94% white, 6% black; 3% Hispanic). In contrast, the 274 elders in this cohort are community-based and ethnically diverse (39% white, 40% black, 21% other; 78% Hispanic). Confirming previous observations, psychotic features were associated with poorer function and mental status and extrapyramidal signs with poorer function. DISCUSSION: This new cohort will allow us to test observations made in our original clinic-based cohorts in patients that may be more representative of the general community.
Authors: S M Albert; D M Jacobs; M Sano; K Marder; K Bell; D Devanand; J Brandt; M Albert; Y Stern Journal: Am J Geriatr Psychiatry Date: 2001 Impact factor: 4.105
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