Literature DB >> 29311087

In Vitro Activities of Miltefosine and Antibacterial Agents from the Macrolide, Oxazolidinone, and Pleuromutilin Classes against Pythium insidiosum and Pythium aphanidermatum.

Erico S Loreto1,2, Juliana S M Tondolo3, Daniele C Oliveira2, Janio M Santurio3, Sydney H Alves1.   

Abstract

We tested 29 isolates of Pythium insidiosum and one isolate of Pythium aphanidermatum to investigate their susceptibility to miltefosine and antibacterial drugs from the macrolide, oxazolidinone, and pleuromutilin classes. We found that miltefosine, azithromycin, clarithromycin, josamycin, linezolid, sutezolid, retapamulin, tiamulin, and valnemulin had inhibitory and cidal activity against the pathogens at concentrations ranging from 0.25 to 64 μg/ml. Our results suggest that these antimicrobials are promising candidates for future studies on pythiosis in animals and humans.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  oomycetes; pythiosis; susceptibility; treatment

Mesh：

Substances：

Year:  2018        PMID： 29311087      PMCID： PMC5826131          DOI： 10.1128/AAC.01678-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  44 in total

Review 1.  New insights into animal pathogenic oomycetes.

Authors:  Andrew J Phillips; Victoria L Anderson; Emma J Robertson; Chris J Secombes; Pieter van West
Journal:  Trends Microbiol       Date:  2007-12-21       Impact factor: 17.079

2.  New insights into the in vitro susceptibility of Pythium insidiosum.

Authors:  Erico S Loreto; Juliana S M Tondolo; Maiara B Pilotto; Sydney H Alves; Janio M Santurio
Journal:  Antimicrob Agents Chemother       Date:  2014-09-15       Impact factor: 5.191

Review 3.  Pleuromutilins: Potent Drugs for Resistant Bugs-Mode of Action and Resistance.

Authors:  Susanne Paukner; Rosemarie Riedl
Journal:  Cold Spring Harb Perspect Med       Date:  2017-01-03       Impact factor: 6.915

4.  Miltefosine is fungicidal to Paracoccidioides spp. yeast cells but subinhibitory concentrations induce melanisation.

Authors:  Diego Conrado Pereira Rossi; Cristina de Castro Spadari; Joshua Daniel Nosanchuk; Carlos Pelleschi Taborda; Kelly Ishida
Journal:  Int J Antimicrob Agents       Date:  2017-03-06       Impact factor: 5.283

5.  Effect of alkylphospholipids on Candida albicans biofilm formation and maturation.

Authors:  Taissa V M Vila; Kelly Ishida; Wanderley de Souza; Kyriakos Prousis; Theodora Calogeropoulou; Sonia Rozental
Journal:  J Antimicrob Chemother       Date:  2012-09-19       Impact factor: 5.790

6.  The cytotoxic activity of miltefosine against Leishmania and macrophages is associated with dynamic changes in plasma membrane proteins.

Authors:  Kelly Souza Fernandes; Paulo Eduardo Narcizo de Souza; Miriam Leandro Dorta; Antonio Alonso
Journal:  Biochim Biophys Acta Biomembr       Date:  2016-10-20       Impact factor: 3.747

7.  Vascular Pythiosis of the Lower Extremity in Northern Thailand: Ten Years' Experience.

Authors:  Termpong Reanpang; Saritphat Orrapin; Saranat Orrapin; Supapong Arworn; Thanate Kattipatanapong; Tanop Srisuwan; Nongnuch Vanittanakom; Suree P Lekawanvijit; Kittipan Rerkasem
Journal:  Int J Low Extrem Wounds       Date:  2015-08-18       Impact factor: 2.057

8.  Miltefosine is effective against Candida albicans and Fusarium oxysporum nail biofilms in vitro.

Authors:  Taissa Vieira Machado Vila; Natália Sousa Quintanilha; Sonia Rozental
Journal:  J Med Microbiol       Date:  2015-09-23       Impact factor: 2.472

Review 9.  Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis.

Authors:  Thomas P C Dorlo; Manica Balasegaram; Jos H Beijnen; Peter J de Vries
Journal:  J Antimicrob Chemother       Date:  2012-07-24       Impact factor: 5.790

10.  Caspofungin in vitro and in vivo activity against Brazilian Pythium insidiosum strains isolated from animals.

Authors:  Daniela Isabel Brayer Pereira; Janio Morais Santurio; Sydney Hartz Alves; Juliana Siqueira Argenta; Luciana Pötter; Andréia Spanamberg; Laerte Ferreiro
Journal:  J Antimicrob Chemother       Date:  2007-09-03       Impact factor: 5.790
View more
  4 in total

1.  The Repurposed Drug Disulfiram Inhibits Urease and Aldehyde Dehydrogenase and Prevents In Vitro Growth of the Oomycete Pythium insidiosum.

Authors:  Theerapong Krajaejun; Tassanee Lohnoo; Wanta Yingyong; Thidarat Rujirawat; Yothin Kumsang; Passara Jongkhajornpong; Sirin Theerawatanasirikul; Weerayuth Kittichotirat; Onrapak Reamtong; Hanna Yolanda
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

2.  Melaleuca alternifolia formulations in the treatment of experimental pythiosis.

Authors:  Júlia de Souza Silveira; Carolina Litchina Brasil; Caroline Quintana Braga; Ândrios da Silva Moreira; Helen Cabaldi Franz; Rosimeri Zamboni; Eliza Simone Sallis; Ana Paula Albano; Cristina Gomes Zambrano; Lara Colles Araujo; Cristiane de Bona da Silva; Luciana Pötter; Sônia de Avila Botton; Daniela Isabel Brayer Pereira
Journal:  Braz J Microbiol       Date:  2022-03-03       Impact factor: 2.214

3.  Efficacy of Azithromycin and Miltefosine in Experimental Systemic Pythiosis in Immunosuppressed Mice.

Authors:  Erico S Loreto; Juliana S M Tondolo; Francielli P K de Jesus; Camila M Verdi; Carla Weiblen; Maria I de Azevedo; Glaucia D Kommers; Janio M Santurio; Régis A Zanette; Sydney H Alves
Journal:  Antimicrob Agents Chemother       Date:  2018-12-21       Impact factor: 5.191

Review 4.  Review of methods and antimicrobial agents for susceptibility testing against Pythium insidiosum.

Authors:  Hanna Yolanda; Theerapong Krajaejun
Journal:  Heliyon       Date:  2020-04-12
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.