Literature DB >> 2721539

Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients.

I Bonnacker1, D Berdel, R Süverkrüp, A von Berg.   

Abstract

The renal clearance of theophylline (TH) and its metabolites 1,3-dimethyluric acid (1,3-DMU), 3-methylxanthine (3-MX), and 1-methyluric acid (1-MU) has been studied in 10 children aged 8 months to 14 years. Individual renal clearances were calculated from serum levels and amounts excreted in urine after i.v. administration of the parent drug. The clearance of 1,3-DMU was found to depend both upon urine flow rate and age, which are interrelated. An effect of urinary pH was expected, but was not studied. Consistent age-dependent changes in the relative quantities of metabolites excreted were not observed.

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Year:  1989        PMID： 2721539     DOI： 10.1007/BF00609186

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  10 in total

1.  Development of renal control of salt and fluid homeostasis during the first year of life.

Authors:  A Aperia; O Broberger; K Thodenius; R Zetterström
Journal:  Acta Paediatr Scand       Date:  1975-05

2.  Pharmacokinetic aspects of theophylline in premature newborns.

Authors:  J V Aranda; D S Sitar; W D Parsons; P M Loughnan; A H Neims
Journal:  N Engl J Med       Date:  1976-08-19       Impact factor: 91.245

3.  Micro-scale method for theophylline in body fluids by reversed-phase, high-pressure liquid chromatography.

Authors:  J J Orcutt; P P Kozak; S A Gillman; L H Cummins
Journal:  Clin Chem       Date:  1977-03       Impact factor: 8.327

4.  An automated HPLC assay for simultaneous quantitation of methylated xanthines and uric acids in urine.

Authors:  D D Tang-Liu; S Riegelman
Journal:  J Chromatogr Sci       Date:  1982-04       Impact factor: 1.618

5.  High-performance liquid-chromatographic determination theophylline in plasma.

Authors:  G W Peng; M A Gadalla; W L Chiou
Journal:  Clin Chem       Date:  1978-02       Impact factor: 8.327

6.  Nonlinear theophylline elimination.

Authors:  D D Tang-Liu; R L Williams; S Riegelman
Journal:  Clin Pharmacol Ther       Date:  1982-03       Impact factor: 6.875

7.  Effect of age on patterns of theophylline metabolism.

Authors:  J J Grygiel; D J Birkett
Journal:  Clin Pharmacol Ther       Date:  1980-10       Impact factor: 6.875

8.  Urine flow-dependence of theophylline renal clearance in man.

Authors:  D D Tang-Liu; T N Tozer; S Riegelman
Journal:  J Pharmacokinet Biopharm       Date:  1982-08

9.  Total theophylline clearance in childhood: the influence of age-dependent changes in metabolism and elimination.

Authors:  D Berdel; R Süverkrüp; G Heimann; A von Berg; N Liappis; A Stühmer
Journal:  Eur J Pediatr       Date:  1987-01       Impact factor: 3.183

10.  Non-linear elimination processes of theophylline.

Authors:  U Gundert-Remy; R Hildebrandt; N Hengen; E Weber
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953
  10 in total
  2 in total

1.  Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats.

Authors:  H J Kuh; C K Shim
Journal:  Arch Pharm Res       Date:  1994-04       Impact factor: 4.946

2.  Exploring the Association between Urine Caffeine Metabolites and Urine Flow Rate: A Cross-Sectional Study.

Authors:  Shou En Wu; Wei-Liang Chen
Journal:  Nutrients       Date:  2020-09-13       Impact factor: 5.717
  2 in total

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