Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Total theophylline clearance in childhood: the influence of age-dependent changes in metabolism and elimination.

Literature DB >> 3582403

Total theophylline clearance in childhood: the influence of age-dependent changes in metabolism and elimination.

D Berdel, R Süverkrüp, G Heimann, A von Berg, N Liappis, A Stühmer.

Abstract

Theophylline metabolism and elimination during childhood are age-dependent. The total clearance, which is the sum of metabolic and renal clearances is highest in infants and young children. To differentiate between the two pathways, theophylline concentrations were measured in both serum and urine in 16 children aged 2 weeks-16 years using the fluorescence polarization immunoassay. It was found that both partial clearances assume maximal values at about the same age, but the fraction of total clearance attributable to the renal route decreases continuously.

Entities: Chemical Species

Mesh：

Substances：
Theophylline

Year: 1987 PMID： 3582403 DOI： 10.1007/bf00647281

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

15 in total

1. Pharmacokinetics of theophylline in children with asthma.

Authors: E F Ellis; R Koysooko; G Levy
Journal: Pediatrics Date: 1976-10 Impact factor: 7.124

2. Pharmacokinetics of intravenous theophylline.

Authors: P A Mitenko; R I Ogilvie
Journal: Clin Pharmacol Ther Date: 1973 Jul-Aug Impact factor: 6.875

3. Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline.

Authors: J W Jenne; M S Wyze; F S Rood; F M MacDonald
Journal: Clin Pharmacol Ther Date: 1972 May-Jun Impact factor: 6.875

4. [Fluorescence polarization immunoassay, a new measuring technic in routine clinicochemical diagnosis of drug levels].

Authors: N Liappis
Journal: Klin Padiatr Date: 1985 Jul-Aug Impact factor: 1.349

Review 5. Aminophylline.

Authors: J A Stirt; S F Sullivan
Journal: Anesth Analg Date: 1981-08 Impact factor: 5.108

6. Effect of age on patterns of theophylline metabolism.

Authors: J J Grygiel; D J Birkett
Journal: Clin Pharmacol Ther Date: 1980-10 Impact factor: 6.875

7. Developmental aspects of theophylline metabolism in premature infants.

Authors: K Y Tserng; F N Takieddine; K C King
Journal: Clin Pharmacol Ther Date: 1983-04 Impact factor: 6.875

8. [Theophylline therapy in obstructive respiratory diseases. 1. Bioavailability and pharmacokinetics of various theophylline preparations (author's transl)].

Authors: S Wemhöner; M Oellerich; G Sybrecht
Journal: Prax Klin Pneumol Date: 1981-01

Total theophylline clearance in childhood: the influence of age-dependent changes in metabolism and elimination.

1. Pharmacokinetics of theophylline in children with asthma.

2. Pharmacokinetics of intravenous theophylline.

3. Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline.

4. [Fluorescence polarization immunoassay, a new measuring technic in routine clinicochemical diagnosis of drug levels].

Review 5. Aminophylline.

6. Effect of age on patterns of theophylline metabolism.

7. Developmental aspects of theophylline metabolism in premature infants.

8. [Theophylline therapy in obstructive respiratory diseases. 1. Bioavailability and pharmacokinetics of various theophylline preparations (author's transl)].

9. Pharmacologic considerations in the therapy of neonatal apnea.

10. Theophylline metabolism during the first month of life and development.

1. Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients.

2. Evaluation of theophylline pharmacokinetics in a pediatric population using mixed effects models.