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Literature DB >> 2720891

Effect of ether lipids on mouse granulocyte-macrophage progenitor cells.

K Vehmeyer¹, D J Kim, G A Nagel, H Eibl, C Unger.

Abstract

In this study we determined the potential bone marrow toxicity of the ether lipid derivatives 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine (OcMe-G-3-PC), 1-0-hexadecyl-propanediol-2-phosphocholine (He-Pr-2-PC), and hexadecylphosphocholine (He-PC). OcMe-G-3-PC inhibited the proliferation of mouse granulocyte-macrophage progenitor cells (GM-CFCs) at a dose of 1 micrograms/ml, whereas He-Pr-2-PC and He-PC started to inhibit the growth of hemopoietic precursors at 5 micrograms/ml. In contrast to this finding, NMRI mice given 10 mg/kg i.v. daily for 4 weeks and 20 or 30 mg/kg for 5 days showed no bone marrow toxicity. We conclude that the dose-dependent toxic effects observed in vitro are within the physiological tolerance in vivo.

Entities: Chemical Disease Species

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Year: 1989 PMID： 2720891 DOI： 10.1007/BF00254107

Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333

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2 in total

Effect of ether lipids on mouse granulocyte-macrophage progenitor cells.

1. [Blood-brain barrier and the penetration of cytostatic drugs].

2. Effect of synthetic phospholipids on platelet aggregation and serotonin release.

3. Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils.

4. Clinical phase I pilot study of the alkyl lysophospholipid derivative ET-18-OCH3.

5. Experimental studies on the role of alkyl lysophospholipids in autologous bone marrow transplantation.

6. Alkyl phosphocholines: toxicity and anticancer properties.

7. Distribution and metabolism of hexadecylphosphocholine in mice.

8. Effect of lipid derivatives on invasion in vitro and on surface glycoproteins of three rodent cell types.

9. Characterization of the antitumor activity of hexadecylphosphocholine (D 18506).

10. Induction of differentiation of cultured human and mouse myeloid leukemia cells by alkyl-lysophospholipids.

1. Effects of antineoplastic phospholipids on parameters of cell differentiation in U937 cells.

2. Erufosine, a novel alkylphosphocholine, in acute myeloid leukemia: single activity and combination with other antileukemic drugs.