Literature DB >> 3444386

Distribution and metabolism of hexadecylphosphocholine in mice.

A Breiser1, D J Kim, E A Fleer, W Damenz, A Drube, M Berger, G A Nagel, H Eibl, C Unger.   

Abstract

Distribution and metabolic fate of radiolabeled hexadecylphosphocholine (He-PC) has been studied in mice. It is demonstrated that He-PC is well-absorbed from the intestinal tract, intravenous (IV) and oral administration lead to similar distributions throughout the body, the highest accumulation of radioactivity occurs in liver, lung and kidney, and the metabolic products are radioactive choline, phosphocholine and 1,2-diacylphosphatidylcholine. The occurrence of these metabolites indicates that phospholipases C and D may be involved in He-PC breakdown.

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Year:  1987        PMID： 3444386     DOI： 10.1007/BF02535556

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  4 in total

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Journal:  Can J Biochem Physiol       Date:  1959-08

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Journal:  Biochim Biophys Acta       Date:  1978-07-25

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Authors:  M R Mauk; R C Gamble; J D Baldeschwieler
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205
  4 in total
  22 in total

1.  Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice.

Authors:  P Escobar; V Yardley; S L Croft
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

2.  Reductions in skin and systemic parasite burdens as a combined effect of topical paromomycin and oral miltefosine treatment of mice experimentally infected with Leishmania (Leishmania) amazonensis.

Authors:  Marta Gontijo Aguiar; Aline Márcia Machado Pereira; Ana Paula Fernandes; Lucas Antonio Miranda Ferreira
Journal:  Antimicrob Agents Chemother       Date:  2010-08-16       Impact factor: 5.191

3.  Intestinal absorption of miltefosine: contribution of passive paracellular transport.

Authors:  Cécile Ménez; Marion Buyse; Christophe Dugave; Robert Farinotti; Gillian Barratt
Journal:  Pharm Res       Date:  2007-03       Impact factor: 4.200

4.  Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.

Authors:  Fred Widmer; Lesley C Wright; Daniel Obando; Rosemary Handke; Ranjini Ganendren; David H Ellis; Tania C Sorrell
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

5.  Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid.

Authors:  Stefan R Vink; Jan H M Schellens; Wim J van Blitterswijk; Marcel Verheij
Journal:  Invest New Drugs       Date:  2005-08       Impact factor: 3.850

Review 6.  Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.

Authors:  E J Meuillet
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

7.  Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis.

Authors:  Nathan P Wiederhold; Laura K Najvar; Rosie Bocanegra; William R Kirkpatrick; Tania C Sorrell; Thomas F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2012-11-19       Impact factor: 5.191

8.  Pharmacokinetics and metabolism of a new antitumor semisynthetic ether phospholipid, 14C-labeled plasmanyl-(N-acyl)ethanolamine, in mice bearing sarcoma Mc11.

Authors:  J Kára; N I Zimakova; E A Serebryakova; V Dĕdková; A E Zolotaryov
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

9.  Single oral fixed-dose praziquantel-miltefosine nanocombination for effective control of experimental schistosomiasis mansoni.

Authors:  Maha M Eissa; Mervat Z El-Azzouni; Labiba K El-Khordagui; Amany Abdel Bary; Riham M El-Moslemany; Sara A Abdel Salam
Journal:  Parasit Vectors       Date:  2020-09-15       Impact factor: 3.876

10.  Effect of ether lipids on mouse granulocyte-macrophage progenitor cells.

Authors:  K Vehmeyer; D J Kim; G A Nagel; H Eibl; C Unger
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333
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