Literature DB >> 27207371

Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for colon cancer.

Zhanjun Guo1, Shengnan Zhao1, Haiyan Fan1, Yanming Du2, Yufei Zhao1, Guiying Wang2.   

Abstract

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in a number of cancers. We investigated the colon cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 146T/C, 195T/C, 324C/G, 16261C/T, and 16304T/C as well as the minor allele of 309C/C insert were significantly associated with an increased risk for colon cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for colon cancer risk evaluation.

Entities:  

Keywords:  Colon cancer; D-Loop; SNPs; mtDNA

Mesh：

Substances：

Year:  2016        PMID： 27207371     DOI： 10.3109/19401736.2014.1003920

Source DB:  PubMed          Journal:  Mitochondrial DNA A DNA Mapp Seq Anal        ISSN： 2470-1394            Impact factor:   1.514


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