Elevated Atmospheric Levels of Benzene and Benzene-Related Compounds from Unconventional Shale Extraction and Processing: Human Health Concern for Residential Communities.

BACKGROUND: The advancement of natural gas (NG) extraction across the United States (U.S.) raises concern for potential exposure to hazardous air pollutants (HAPs). Benzene, a HAP and a primary chemical of concern due to its classification as a known human carcinogen, is present in petroleum-rich geologic formations and is formed during the combustion of bypass NG. It is a component in solvents, paraffin breakers, and fuels used in NG extraction and processing (E&P).
OBJECTIVES: The objectives of this study are to confirm the presence of benzene and benzene-related compounds (benzene[s]) in residential areas, where unconventional shale E&P is occurring, and to determine if benzene[s] exists in elevated atmospheric concentrations when compared to national background levels.
METHODS: Ambient air sampling was conducted in six counties in the Dallas/Fort Worth Metroplex with passive samples collected in evacuated 6-L Summa canisters. Samples were analyzed by gas chromatography/mass spectrometry, with sampling performed at variable distances from the facility fence line.
RESULTS: Elevated concentrations of benzene[s] in the atmosphere were identified when compared to U.S. Environmental Protection Agency's Urban Air Toxics Monitoring Program. The 24-hour benzene concentrations ranged from 0.6 parts per billion by volume (ppbv) to 592 ppbv, with 1-hour concentrations from 2.94 ppbv to 2,900.20 ppbv.
CONCLUSION: Benzene is a known human carcinogen capable of multisystem health effects. Exposure to benzene is correlated with bone marrow and blood-forming organ damage and immune system depression. Sensitive populations (children, pregnant women, elderly, immunocompromised) and occupational workers are at increased risk for adverse health effects from elevated atmospheric levels of benzene[s] in residential areas with unconventional shale E&P.

Introduction

Due to advances in horizontal drilling and hydraulic fracturing (fracking) technology, the extraction of natural gas (NG) and natural gas liquids (NGLs) in unconventional shale geologic formations is occurring at an unprecedented rate across the United States (U.S.). Many of these energy-rich formations lie beneath developed urban areas. Extraction of energy within these urban areas has been termed “urban drilling.” The number of gas wells in the Barnett Shale formation (North Texas) increased from 276 (2000) to more than 24,967 (2014), representing an 8,946% increase.1 Development of energy from these formations may be beneficial to the economy, but consideration of the effect on the atmosphere, climate, and people who live near these facilities should also be addressed. This study is one of the first field studies to identify benzene and benzene-related compounds (benzene[s]) in the atmosphere at various concentrations from emissions associated with extraction and processing (E&P) of NG in residential areas where urban drilling is occurring.

Communities have raised concerns for a potential increased exposure to hazardous air pollutants (HAPs) associated with NG E&P operation emissions and the effects worsening air quality may have on human health.2 HAPs (“toxic air pollutants”) or (“air toxics”) have been defined by the U.S. Environmental Protection Agency (U.S. EPA) as “pollutants that cause or may cause cancer or other serious health effects, such as reproductive effects or birth defects, or adverse environmental and ecological effects.”3 The 1990 Clean Air Act Amendments (CAAA) direct the U.S. EPA to set standards for all major sources of air toxics. The U.S. EPA is required to control chemicals identified and designated by the 1990 CAAA list of 187 HAPs, which include benzene.4 Emissions from NG and NGL E&P may contain HAPs or toxic air pollutants known or suspected to cause cancer and other serious health effects. Benzene is a primary chemical of concern due to its classification by the International Agency for Research on Cancer (IARC) as a Group 1 carcinogen and a Group A known human carcinogen according to the U.S. EPA.5,6 Exposure to benzene has been correlated to an increased risk of leukemia (acute myelogenous, acute lymphoblastic leukemia, and chronic myeloid leukemia), aplastic anemia, and myelodysplastic syndrome (MDS).7,8 Additionally, many HAPs are volatile organic compounds (VOCs) and contribute to the formation of ozone and act as a factor in climate change. Ozone and climate change are implicated in affecting human health adversely.9 Extraction in energy-rich reservoirs is occurring in regions already deemed as nonattainment areas according to the U.S. EPA National Ambient Air Quality Standards. Transportation has historically been considered the primary factor in North Texas air quality problems. A more comprehensive look at other major contributing factors, including emissions from NG and NGL E&P, must be considered in the overall plan of attainment for a more holistic approach.

Previous studies identified air pollutants including particulate matter, nitrogen and sulfur oxides, carbon monoxide, methane and associated C1–C6 hydrocarbons, sulfide compounds, and VOCs in emissions from NG and NGL E&P operations.10–26 Reporting guidelines for fugitive air emissions require quantifying total VOCs but do not require identification of specific VOCs that are HAPs, including benzene or benzene[s].

The extraction of NG from an unconventional shale geologic formation is a multistage process involving pad site construction, well drilling operations, hydraulic fracturing, flowback and stimulation of the well for production, and completion of the well before production occurs. Production and processing of NG may include separation, dehydration (removing water from the gas stream) and desulfurization (removal of sulfur compounds), storage of liquids (natural or light gas liquids, condensate and produced water) in tanks, compression, and transmission. After the well is completed, maintenance may require workover or intervention operations to restimulate or clear the well to increase production.27 During each of these stages, VOCs, including benzene and benzene-related chemicals, may escape into the atmosphere from fugitive emissions and equipment leaks.28

Unconventional gas reservoirs are shale or limestone in origin with low-permeability source rock (tight deposits), requiring hydraulic fracturing and horizontal drilling to extract methane from the compacted layers of rock. Conventional reservoirs are sedimentary (sands, sandstone, limestone, and dolomites) in origin with large permeable rock reservoirs that allow the gas to migrate more freely compared to unconventional tight depositions. Benzene occurs naturally in these petroleum-rich (oil and NG) geologic formations. It is also formed during the combustion of bypass NG, the predominant fuel used for the compression of NG. Benzene and benzene[s] are a component of many solvents, paraffin breakers, and fuels used during E&P operations, as reported by the U.S. House of Representatives Committee on Energy and Commerce, Minority Staff report Chemicals Used in Hydraulic Fracturing,29 and can occur naturally as a product of pyrolysis.30

The intrinsic chemical and physical properties of VOCs determine whether they exist as a gas or in vapor state. Due to its low boiling point (80.1 °C, 176.2 °F), benzene can easily vaporize (at a temperature of 25 °C, 77 °F, 0.13 atm) and migrate into indoor air from outside sources.31–33 It is also highly flammable in the presence of open flames and sparks. As an aromatic hydrocarbon with high volatility, benzene is often present in higher concentration in the atmosphere than aliphatic compounds.34,35 Benzene may be emitted to the atmosphere as a primary chemical in emissions or leaks and can undergo reactions in the atmosphere forming secondary benzene[s]. Degradation in the atmosphere occurs primarily by indirect phototransformation. With high stability and minimal reactivity, the half-life of benzene in the atmosphere can range from 3 to 10 days (tropospheric half-life is 7–22 days), enabling it to be transported locally and regionally.36

Although highly stable in the atmosphere, benzene reacts with other compounds, particularly OH radicals, primarily by substitution of hydrogen atoms and addition of methyl groups. As double bonds can be cleaved by oxidative reagents such as ozone, it can rapidly add bromine (Br) or chlorine (Cl) atoms forming chlorobenzene (C6H5Cl) or bromobenzene (C6H5Br).37 Its low flash point (−11.1 °C, 12.02 °F) increases the risk of explosion when chlorine and light react with vapors of benzene. Benzene is capable of mixing with acetone [(CH3)2CO], alcohol (CnH2n+1 + OH), carbon disulfide (CS2), carbon tetrachloride (CCL4), and chloroform (CHCl3), common chemical compounds used in NG extraction, without separating into two phases. This miscibility increases the risk for human exposure.38 Secondary compounds formed during this process may be toxic to humans as well.

Many VOCs present in NG emissions are aromatic double-bonded benzene hydrocarbons, existing in a gaseous vapor state not far removed from its liquid phase. This allows it to be easily absorbed onto surfaces or condensed into a liquid. Benzene and benzene-related compounds are soluble in water (1.8 g/L at 25 °C), enabling them to migrate easily into sub-surface soil and groundwater. With low density (0.879 g/mL at 20 °C, 68 °F), benzene easily penetrates groundwater and becomes miscible. It can form soil gas at distances from the original contamination source.39,40

Elevated benzene compounds in the atmosphere may present an increased potential for adverse health effects to the general public, occupational workers, and particularly sensitive populations (children, pregnant women, the elderly, and immunocompromised) whose unique physiology may place them at a greater risk.41–43

Objectives

The objectives of this study are to evaluate ambient air for the presence of benzene and benzene[s] in residential areas where unconventional shale E&P is occurring and to determine if atmospheric levels of benzene and benzene[s] are elevated due to E&P activity when compared to the U.S. EPA Urban Air Toxics Monitoring Program (UATMP). The UATMP is the most comprehensive air monitoring program in the U.S. and includes urban, suburban, rural, and industrial monitored sites across the U.S.

Materials and Methods

Ambient air sampling was performed in primarily residential areas of six counties in the Dallas/Fort Worth Metroplex influenced by urban drilling and emissions from unconventional shale gas E&P operations. Five of the six counties (Parker, Tarrant, Johnson, Denton, and Somerville) were classified as nonattainment areas at the time of sampling, and the sixth county (Wise) was deemed as nonattainment status in 2012. The residential areas were chosen due to the presence and expansion of urban drilling within residential neighborhoods and low potential for confounding emission sources. Fifty sets of monitoring data were obtained in 39 different locations over a two-year period (2008–2010). Ambient air sampling was captured using certified sterilized evacuated stainless steel 6-L Summa canisters, with a certified 24-hour mass-flow regulator attached. The 24-hour regulator allowed for continuous sampling of ambient air over a 24-hour period of time as compared to an instantaneous/grab sample. Grab samples have inherent error and may capture peak emissions during equipment start-up, which is not reflective of constant state emissions. A 24-hour sample period does not reflect maximum high emission readings or minimum emissions but rather allows for the ability to assess constant conditions or average chemical concentrations and is more representative of a chronic chemical exposure. Canisters were placed in a stable location at ground level. If the environment posed a risk of particulate matter interference with the flow regulator, a J-hook was attached to the flow meter, preventing clogging of the regulator intake valve. Field sampling procedures followed the American Society for Testing and Materials Method D-1357-95 (2011), Standard Practice for Planning the Sampling of the Ambient Atmosphere. Canisters were retrieved from the field and delivered to the laboratory within 12 hours of recovery. Samples were analyzed for benzene and benzene[s] using gas chromatography/mass spectrometry according to the EPA Compendium Method Toxic Organics (TO-14A) by a certified laboratory within 24 hours of receipt. Chemical concentration values below laboratory minimal detection level (MDL) were deemed nondetect (ND). ND does not equate to zero; therefore, in statistical analysis, the MDL is taken into consideration. As benzene is known to be present in the combustion emissions of many fuels, analysis of the samples for the presence of lower chain C1–C6 hydrocarbons by performance of Light Hydrocarbon test was requested along with the TO-14A. The Light Hydrocarbon test captures the compounds of methane (CH4), ethane (C2H6), propane (C3H6), butane (C4H10), and pentane (C5), known products of NG extraction. Meteorological conditions on the dates of sampling were retrieved from the web site of Quality Controlled Local Climatological Data, the National Climatic Data Center (www.ncdc.noaa.gov), using the closest airport to each sampled location. Meteorological data were recorded for each sample and included temperature ranges (minimum and maximum), wind direction and velocity (minimum and maximum miles/hour), humidity, and any precipitation event. Equipment and processes at E&P sites can vary; therefore, emissions can vary depending on the distance from the site monitoring occurred and equipment present at the time of monitoring. A comprehensive evaluation of equipment variability and distance from receptor was previously published by authors.26 Complaints related to emissions vary as to the magnitude of the specific chemical concentration, odor characteristics (acrid vs. sweet), and health impact. Additionally, specific chemicals may have more pungent unfavorable odors (ie, sulfur compounds) and therefore draw a higher complaint response.

Sampling was performed at variable distances from the fence line of facilities in order to capture a more true ambient air condition in residential areas affected by E&P emissions rather than capturing direct emissions from a facility with fence line monitoring. The majority of the sampling was performed in rural or residential areas with light transportation emissions other than E&P emissions. In this study, the distance from other potential emission sources, including gas stations and major road intersection, was also identified in relation to locations monitored.

Results

Ambient air sampling confirmed elevated concentrations of benzene and 18 benzene[s] in ambient air in residential areas where unconventional shale NG and NGL E&P operations were occurring. Benzene was present in 78% (39 of 50) of the locations sampled. Concentrations ranged from 0.6 parts per billion by volume (ppbv) to 592 ppbv, based on 24-hour passive sampling (Table 1). Acute one-hour concentrations for benzene ranged from 2.93 ppbv to 2,900.20 ppbv.44 The summary statistics of 24-hour and 1-hour chemical concentrations are provided in Table 1. The number of NDs varied widely among benzene[s]. Toluene was present in 94% of samples and strongly correlated to benzene[s]. Xylene (m- & p-) was present in 86% of samples. While some benzene[s] are emitted directly into the atmosphere (primary compounds), other benzene[s] may be formed secondarily through exchanges or conversions with chemicals present in the atmosphere. The infrequent detection of certain benzene compounds indicates that they may be secondary atmospheric compounds rather than primary compounds from direct emissions.

Table 1

Summary statistics – 24-hour and 1-hour chemical concentrations.

CHEMICALS (UNIT)	24-Hr					1-Hr					ND
	MIN(ppbv)	MAX(ppbv)	MEDIAN(ppbv)	MEAN(ppbv)	SD(ppbv)	MIN(ppbv)	MAX(ppbv)	MEDIAN(ppbv)	MEAN(ppbv)	SD(ppbv)
Benzene	0.6	592	0.89	18.53	83.75	2.94	2900.2	5	87.39	402.58	39
Toluene/methylbenzene	0.34	276	2.55	19.45	48.77	1.67	1352.12	11.57	78.17	217.4	3
Ethylbenzene	0.2	113	0.53	4.42	16.03	0.98	553.58	5.59	36.22	102.51	23
Xylene, m&p	0.25	221	1.68	15.69	43.1	1.22	1082.67	9.17	72.63	205.76	7
Xylene, o-	0.2	39.4	0.85	3.19	6.7	0.98	193.02	6.13	19.51	36.2	15
Trimethylbenzene, 1,3,5-	0.2	9.95	0.59	1.43	2.12	0.98	48.74	6.5	11.6	12.39	25
Trimethylbenzene, 1,2,4-	0.2	60.4	0.4	3.45	10.79	0.98	295.6	5.78	35.03	75.72	27
Styrene/Vinylbenzene	0.2	43.4	0.37	1.91	6.22	0.98	212.62	4.23	17.56	43.4	26
Dichlorobenzene, 1,4-	0.2	4.43	0.3	0.55	0.66	0.98	21.7	2.2	2.73	1.27	45
Trichlorobenzene, 1,2,4-	0.28	13.5	0.67	1.12	1.93	1.37	66.14	3.52	10.9	22.4	10
Trimethyl benzene	0.3	366	1.4	15.18	58.39	1.47	1793.03	5.78	35.03	75.72	46
Ethylmethyl benzene	0.3	42.8	1.4	3.15	6.74	1.47	209.68	120.1	131.86	72.78	47
1-Propynyl benzene	0.3	7.2	1.4	1.74	1.13	35.29	166.67	100.98	100.98	92.89	47
Propyl benzene	0.3	23.5	1.4	2.08	3.16	1.47	115.13	115.2	115.2	NA	48
Diethyl benzene	0.3	93.4	1.4	4.14	13.56	1.47	457.57	312.5	312.5	NA	48
Methyl-methylethyl benzene/methylcumene	0.3	84.7	1.4	3.31	11.65	1.47	414.94	414.94	414.94	205.55	48
Tetramethyl benzene	0.3	36.4	1.4	2.76	5.69	1.47	178.32	144.85	144.85	47.49	48
1-Methyl propenylbenzene	0.3	51	1.4	2.63	6.96	1.47	249.85	250	250	NA	49
2-Methyl propenylbenzene	0.3	95.9	1.4	3.53	13.2	1.47	469.81	469.81	469.81	NA	49

Chemical concentrations in the atmosphere are dependent on distance from the facility to the receptor, meteorological conditions (wind, temperature, humidity, precipitation), and specific chemical characteristics. Vertical dispersion is influenced by a wide range of temporal and spatial scales. VOCs, by their very nature, are volatile and easily change phase from liquid to gas, depending on the temperature and vapor pressure of the specific chemical. Atmospheric concentrations of benzene[s] are dependent on whether the emission source is one of combustion, pyrolysis, or fugitive leaks from tanks, valves, or pipelines. In a previous publication by the authors,26 a chemical fingerprint was statistically correlated with combustion, blown wells, and presence of methane. Benzene, toluene, ethylbenzene, and xylene (BTEX) and trimethylbenzene (1,2,4-TMB and 1,3,5-TMB) compounds were highly correlated to compressors and therefore to products of combustion. Due to the high volatility of benzene, the atmospheric half-life varies with evaporation, resulting in 2.7- to 5-hour half-life, while combustion can result in an 8-day half-life and photolysis can result in 16.9-day half-life. The scavenging effect of precipitation on VOCs is well known and is a significant sink for atmospheric benzene. Benzene being highly reactive may also combine with other chemicals forming secondary benzene[s].

The variability of benzene in the atmosphere is further presented in Figure 1. Benzene showed the highest variability in the atmosphere with several high readings (592, 81.7, 77.7, and 55.4 ppbv), affecting the central tendency and median. While a single value (outlier) could be considered to skew statistical data, it is never considered irrelevant and deleted. All data are relevant when evaluating human health risk, and single high values can be valuable indicators for acute high chemical exposure and indicators for incomplete combustion of fuel or a mechanical defect. The primary chemicals with the greatest variability consistently appear to be BTEX compounds from combustion emissions.

Figure 1

Variability in atmospheric Benzene[s] concentrations.

To determine if other emission sources could be contributing factors to atmospheric benzene concentrations, the distance from the site monitored to the nearest gas station was calculated.45 Research indicates that emissions from gas stations influence atmospheric conditions within 250 m of a station with concentrations of ethylbenzene and xylenes being higher due to gasoline evaporation.46 In total, 87% of locations monitored were >0.5 miles (804.7 m) from the nearest gas station, with only five locations <0.5 miles as presented in Figure 2.

Figure 2

Distance from the site monitored to the nearest gas station.

Further analysis of the potential influence of transportation emissions on atmospheric benzene concentrations was conducted by calculating the distance from the site monitored to the closest intersection. Studies on roadway vehicle emissions show that emissions can affect atmospheric conditions within 500 feet (152.4 m) of the roadway.47 Five locations monitored in this study were within a half mile (2,640 feet, 804.7 m) of a roadway intersection. The closest monitored site was 897 feet (273.4 m) from a roadway intersection [Fig. 3]. Therefore, the contributing source of atmospheric benzene in this study was determined not to be from roadway emissions.

Figure 3

Distance from the site monitored to major intersection.

Atmospheric chemical concentrations in this study were then compared to the U.S. EPA UATMP study. The UATMP study is the most comprehensive monitoring program in the U.S. and includes urban, suburban, rural, and industrial locations across the country.48 Years 2008–2011 were included for a more comprehensive analysis. Of the 19 benzene compounds found in this study, only 11 compounds were monitored consistently in the UATMP studies and could be directly compared. The maximum values are presented in Table 2.

Table 2

Comparison of benzene and benzene-related chemical concentrations to UATMP national concentrations.

POLLUTANT	CURRENT STUDY MAX(ppbv)	UATMP 2008–09 MAX(ppbv)	UATMP 2010 MAX(ppbv)	UATMP 2011 MAX(ppbv)
Benzene	592	10.7	7.89	2.17
Toluene/Methylbenzene	276	60.9	63.1	22.7
Ethylbenzene	113	0.03	33.3	7.25
Xylene, m&p-	221	6.53	14.6	2.7
Xylene, o-	39.4	2.32	4.32	0.888
Trimethylbenzene, 1,3,5-	9.95	2.46	1.71	0.187
Trimethylbenzene, 1,2,4-	60.4	7.64	2.85	0.562
Styrene/Vinylbenzene	43.4	6.39	105	3.06
Dichlorobenzene, 1,4-	4.43	1.26	*NC	1.26
Trichlorobenzene, 1,2,4-	13.5	0.57	*NC	0.067
Propylbenzene	23.5	2.0	2.89	46.4

Note:

NC = Not collected.

When comparing the concentrations of benzene and benzene[s] present in the residential areas of the Barnett Shale to the UATMP study, concentrations in this study exceeded the national average with few exceptions (styrene 2010, propylbenzene 2011) for the years monitored. 1,4-Dichlorobenzene and 1,2,4-trichlorobenzene could not be compared for 2010 due to noncollection (Table 3).

Table 3

Benzene and benzene[s] exceedances over UATMP national maximum (ppbv).

POLLUTANT	CURRENT STUDY MAX (PPBV)	2008–09 % EXCEED UATMP MAX	2010 % EXCEED UATMP MAX	2011 % EXCEED UATMP MAX
Benzene	592	5,532+	7,503+	27,281+
Toluene/Methylbenzene	276	453+	437+	1,215+
Ethylbenzene	113	376,666+	339+	1,558+
Xylene, m&p-	221	3,384+	1,514+	8,185+
Xylene, o-	39.4	1,698+	912+	4,436+
Trimethylbenzene, 1,3,5-	9.95	404+	581+	5,320+
Trimethylbenzene, 1,2,4-	60.4	790+	2,119+	10,747+
Styrene/Vinylbenzene	43.4	679+	41−	1418+
Dichlorobenzene, 1,4-	4.43	351+	*NC	351+
Trichlorobenzene, 1,2,4-	13.5	2,368+	*NC	20,149+
Propylbenzene	23.5	1175+	813+	50−

Note:

NC = Not Collected.

Benzene was found to be 5,532%, 7,503%, and 27,281% higher in this study when compared to the UATMP studies for years 2008–2011. Toluene/methylbenzene was 453%, 437%, and 1,215% higher. Ethylbenzene was 376,666%, 339%, and 1,558% higher. Xylene (m- & p-) was 3,384%, 1,514%, and 8,185% higher. Xylene (o-) was 1,698%, 912%, and 4,436% higher. 1,3,5-TMB was 404%, 581%, and 5,320% higher. 1,2,4-TMB was 790%, 2,119%, and 10,747% higher. Styrene/vinylbenzene was 679% (2008–2009) and 1,418% (2011) higher but recorded 41% lower in 2010 due to a high reading in the UATMP study of 105 ppbv. 1,4-Dichlorobenzene was 351% higher for 2008–2009 and 2011, with 2010 as a nonreporting year. 1,2,4-Trichlorobenzene was 2,368% and 20,149% higher, with 2010 as a nonreporting year. Propylbenzene was 1,175% and 813% higher in years 2008–2009 and 2010, respectively, while UATMP concentrations were 50% higher in year 2011. There was no explanation given for the higher ambient concentrations of styrene/vinylbenzene or propylbenzene for the years reported.

Benzene concentrations were also found to be elevated when compared to the background benzene levels reported in rural and urban/suburban areas (0.47 ppbv in rural areas and 1.8 ppbv in urban/suburban areas).49 However, these values were obtained from the research conducted by Shah and Singh in 1988 and may not be reflective of current atmospheric background levels.50

Several of the benzene[s] found in ambient air monitoring are known to be used in drilling mud products and components of chemicals used in hydraulic fracturing operations. Xylenes were found to be present in 44 products used in hydraulic fracturing, toluene/methylbenzene was found in 29 products, ethylbenzene in 28 products, 1,2,4-TMB in 21 products, TMBs in 5 products, 1,3,5-TMB in 3 products, and diethylbenzene in 1 product. Benzene compounds may also be present in diesel, heavy aromatic distillate, hydrocarbons, hydrocarbon mixtures or hydrotreated light, or middle petroleum distillates often used in the drilling operation or fracking fluids. Proprietary labeled compounds (in drilling muds or fluids) used during hydraulic fracturing are exempt from specific compound identification and may contain additional benzene[s], although not directly identified.

Once fracturing is completed, the drilling mud must be cleared from the well in order to stimulate production. A flowback operation returns or clears the fluids from the wellbore and may result in the release of benzene[s] to the atmosphere. Returned fluids contain high levels of VOCs, including benzene, which can be toxic at high concentrations to workers.51 Fluids cleared from the well are under high pressure when released into the atmosphere and are capable of long-range atmospheric migration, contributing to regional air pollution and climate change.

Conclusion

Benzene and benzene-related chemicals were found to be present in elevated atmospheric concentrations near unconventional shale E&P operations in residential areas when compared to national background levels.

Benzene has been classified as a known human carcinogen (Group 1 and Group A), and as such, no level above zero (0) has been determined to be safe and may be capable of multisystem health effects. Exposure to benzene has been correlated with bone marrow and blood-forming organ damage and immune system depression. Residential areas and occupational workers exposed to high benzene[s] concentrations may have an increased risk of leukemia (acute myelogenous, acute lymphoblastic leukemia, and chronic myeloid leukemia), aplastic anemia, and MDS. Sensitive populations (children, pregnant women, the elderly, and immunocompromised) may be at an elevated risk for adverse health effects due to their unique physiological needs and demands.

While development of these energy-rich geologic formations may be beneficial to the economy, consideration of the effects these chemicals may have on the atmosphere, air quality, and the health of people living near these facilities, particularly the sensitive populations, must also be addressed.