| Literature DB >> 27184968 |
Takayuki Nonoyama1,2, Susumu Wada3, Ryuji Kiyama4, Nobuto Kitamura3, Md Tariful Islam Mredha4, Xi Zhang5, Takayuki Kurokawa1,2, Tasuku Nakajima1,2, Yasuaki Takagi5, Kazunori Yasuda3, Jian Ping Gong1,2.
Abstract
On implanting hydroxyapatite-mineralized tough hydrogel into osteochondral defects of rabbits, osteogenesis spontaneously penetrates into the gel matrix owing to the semi-permeablility of the hydrogel. The gradient layer (around 40 μm thick) contributes quite strong bonding of the gel to bone. This is the first success in realizing the robust osteointegration of tough hydrogels, and the method is simple and feasible for practical use.Entities:
Keywords: biomaterials; double-network hydrogels; hydroxyapatite; osteointegration; semi-permeability
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Year: 2016 PMID： 27184968 DOI： 10.1002/adma.201601030
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849