Literature DB >> 27182219

DNA G-quadruplex and its potential as anticancer drug target.

Onel Buket1, Lin Clement2, Yang DanZhou3.   

Abstract

G-quadruplex secondary structures are four-stranded globular nucleic acid structures form in the specific DNA and RNA G-rich sequences with biological significance such as human telomeres, oncogene-promoter regions, replication initiation sites, and 5' and 3'-untranslated (UTR) regions. The non-canonical G-quadruplex secondary structures can readily form under physiologically relevant ionic conditions and are considered to be new molecular target for cancer therapeutics. This review discusses the essential progress in our lab related to the structures and functions of biologically relevant DNA G-quadruplexes in human gene promoters and telomeres, and the opportunities presented for the development of G-quadruplex-targeted small- molecule drugs.

Entities:  

Keywords:  DNA G-quadruplexes; G-quadruplex-targeted small molecules; anticancer drug target; human telomeres; oncogene promoters

Year:  2014        PMID： 27182219      PMCID： PMC4863707          DOI： 10.1007/s11426-014-5235-3

Source DB:  PubMed          Journal:  Sci China Chem        ISSN： 1869-1870            Impact factor:   9.445


  85 in total

Review 1.  Gene regulation by riboswitches.

Authors:  Maumita Mandal; Ronald R Breaker
Journal:  Nat Rev Mol Cell Biol       Date:  2004-06       Impact factor: 94.444

2.  A sodium-potassium switch in the formation of four-stranded G4-DNA.

Authors:  D Sen; W Gilbert
Journal:  Nature       Date:  1990-03-29       Impact factor: 49.962

3.  Telomere-end processing the terminal nucleotides of human chromosomes.

Authors:  Agnel J Sfeir; Weihang Chai; Jerry W Shay; Woodring E Wright
Journal:  Mol Cell       Date:  2005-04-01       Impact factor: 17.970

4.  Targeting MYC Expression through G-Quadruplexes.

Authors:  Tracy A Brooks; Laurence H Hurley
Journal:  Genes Cancer       Date:  2010-06

5.  Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells.

Authors:  Anjali Verma; Vinod Kumar Yadav; Richa Basundra; Akinchan Kumar; Shantanu Chowdhury
Journal:  Nucleic Acids Res       Date:  2009-02-11       Impact factor: 16.971

6.  Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis.

Authors:  Denis Drygin; Adam Siddiqui-Jain; Sean O'Brien; Michael Schwaebe; Amy Lin; Josh Bliesath; Caroline B Ho; Chris Proffitt; Katy Trent; Jeffrey P Whitten; John K C Lim; Daniel Von Hoff; Kenna Anderes; William G Rice
Journal:  Cancer Res       Date:  2009-09-08       Impact factor: 12.701

Review 7.  Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Authors:  Shankar Balasubramanian; Laurence H Hurley; Stephen Neidle
Journal:  Nat Rev Drug Discov       Date:  2011-04       Impact factor: 84.694

8.  Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes.

Authors:  Prashansa Agrawal; Emmanuel Hatzakis; Kexiao Guo; Megan Carver; Danzhou Yang
Journal:  Nucleic Acids Res       Date:  2013-09-04       Impact factor: 16.971

9.  The major G-quadruplex formed in the human BCL-2 proximal promoter adopts a parallel structure with a 13-nt loop in K+ solution.

Authors:  Prashansa Agrawal; Clement Lin; Raveendra I Mathad; Megan Carver; Danzhou Yang
Journal:  J Am Chem Soc       Date:  2014-01-27       Impact factor: 15.419

10.  Exploring mRNA 3'-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening.

Authors:  Jean-Denis Beaudoin; Jean-Pierre Perreault
Journal:  Nucleic Acids Res       Date:  2013-04-22       Impact factor: 16.971
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  18 in total

1.  Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures.

Authors:  Clement Lin; Guanhui Wu; Kaibo Wang; Buket Onel; Saburo Sakai; Yong Shao; Danzhou Yang
Journal:  Angew Chem Int Ed Engl       Date:  2018-07-18       Impact factor: 15.336

Review 2.  [Application of atomic force microscopy-based single molecule force spectroscopy in G-quadruplex studies].

Authors:  Wenjing Liu; Tong Sun; Ping Zhang; Lin Li; Junhong Lv; Bin Li
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2018-08-30

3.  NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.

Authors:  Clement Lin; Jonathan Dickerhoff; Danzhou Yang
Journal:  Methods Mol Biol       Date:  2019

4.  Binding of anticancer drug daunomycin to a TGGGGT G-quadruplex DNA probed by all-atom molecular dynamics simulations: additional pure groove binding mode and implications on designing more selective G-quadruplex ligands.

Authors:  Zhanhang Shen; Kelly A Mulholland; Yujun Zheng; Chun Wu
Journal:  J Mol Model       Date:  2017-08-08       Impact factor: 1.810

5.  The 3'-end region of the human PDGFR-β core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes.

Authors:  Buket Onel; Megan Carver; Prashansa Agrawal; Laurence H Hurley; Danzhou Yang
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-12-28       Impact factor: 3.770

6.  Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.

Authors:  Clement Lin; Danzhou Yang
Journal:  Methods Mol Biol       Date:  2017

7.  Polarizable Molecular Dynamics Simulations of Two c-kit Oncogene Promoter G-Quadruplexes: Effect of Primary and Secondary Structure on Loop and Ion Sampling.

Authors:  Alexa M Salsbury; Tanner J Dean; Justin A Lemkul
Journal:  J Chem Theory Comput       Date:  2020-04-30       Impact factor: 6.006

8.  A topological transition from bimolecular quadruplex to G-triplex/tri-G-quadruplex exhibited by truncated double repeats of human telomere.

Authors:  Mohan Kumar; Mahima Kaushik; Shrikant Kukreti
Journal:  Eur Biophys J       Date:  2018-06-22       Impact factor: 1.733

9.  A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription.

Authors:  Buket Onel; Megan Carver; Guanhui Wu; Daria Timonina; Salil Kalarn; Marti Larriva; Danzhou Yang
Journal:  J Am Chem Soc       Date:  2016-02-22       Impact factor: 15.419

Review 10.  Advances in the detection of telomerase activity using isothermal amplification.

Authors:  Xiaojin Zhang; Xiaoding Lou; Fan Xia
Journal:  Theranostics       Date:  2017-04-10       Impact factor: 11.556
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