Stephan Polanec1, Thomas H Helbich2, Hubert Bickel1, Katja Pinker-Domenig1, Dietmar Georg3, Shahrokh F Shariat4, Wolfgang Aulitzky5, Martin Susani6, Pascal A Baltzer7. 1. Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna (AKH), Waehringer-Guertel 18-20, A-1090 Wien, Austria. 2. Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna (AKH), Waehringer-Guertel 18-20, A-1090 Wien, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University Vienna (AKH), Waehringer-Guertel 18-20, A-1090 Wien, Austria. 3. Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University Vienna (AKH), Waehringer-Guertel 18-20, A-1090 Wien, Austria; Department of Radiation Oncology, Division of Medical Radiation Physics, Medical University of Vienna (AKH), Waehringer-Guertel 18-20, A-1090 Wien, Austria. 4. Department of Urology, Medical University of Vienna (AKH), Waehringer-Guertel 18-20, A-1090 Wien, Austria. 5. Department of Urology, Confraternität Vienna, Skodagasse 32, A-1080 Wien, Austria. 6. Clinical Institute of Pathology, Medical University of Vienna (AKH), Waehringer-Guertel 18-20, A-1090 Wien, Austria. 7. Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna (AKH), Waehringer-Guertel 18-20, A-1090 Wien, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University Vienna (AKH), Waehringer-Guertel 18-20, A-1090 Wien, Austria. Electronic address: pascal.baltzer@meduniwien.ac.at.
Abstract
PURPOSE: To compare the reproducibility and diagnostic performance of PI-RADS version 2 (v2) and version 1 (v1) for the diagnosis of prostate cancer (PCa) on multiparametric MRI. METHODS: This IRB-approved retrospective study included 65 consecutive biopsy-naïve or biopsy-negative patients suspicious for PCa (mean age: 65 years, mean PSA: 10.8ng/ml) who were undergoing MR-guided biopsy after multiparametric 3T prostate MRI (T2w, DWI, DCE). Two independent readers (R1; R2) scored the prostate lesions according to the v2 score and the v1 sum score. Diagnostic measures (sensitivity, specificity, and area under the ROC-curve) were compared for all cases and stratified by location (transitional zone, TZ, peripheral zone, PZ). Inter-reader agreement was assessed by kappa statistics. RESULTS: Inter reader agreement for v2 and v1 was substantial to almost perfect (kappa v2: 0.71, v1: 0.81). Overall, sensitivity between both readers and methods did not differ (p>0.05). Overall specificity was higher using v1 compared to v2 (R1: p=0.0078, R2: p=0.0313) In the TZ, v2 showed a higher AUC (0.81-0.84) compared to v1 (AUC 0.77-0.78). Here, the sensitivity of v2 (87.5-100%) was higher than that of v1 (75%) while v2 specificity (50%-56.3%) was lower than that of v1 (68.8-75%). In the PZ, AUCs were higher using v1 (AUC 0.82-0.83) compared to v2 (AUC 0.61-0.63). The specificity for v1 was higher (43.8-62.3%) than that for v2 (12.5-18.8%) while both v2 and v1 achieved 100% sensitivity. CONCLUSION: PI-RADS v2 and v1 inter-reader agreement is excellent, but their diagnostic performance differs. While v2 appears to be the preferable method for the evaluation of TZ lesions, v1 performs better in the PZ.
PURPOSE: To compare the reproducibility and diagnostic performance of PI-RADS version 2 (v2) and version 1 (v1) for the diagnosis of prostate cancer (PCa) on multiparametric MRI. METHODS: This IRB-approved retrospective study included 65 consecutive biopsy-naïve or biopsy-negative patients suspicious for PCa (mean age: 65 years, mean PSA: 10.8ng/ml) who were undergoing MR-guided biopsy after multiparametric 3T prostate MRI (T2w, DWI, DCE). Two independent readers (R1; R2) scored the prostate lesions according to the v2 score and the v1 sum score. Diagnostic measures (sensitivity, specificity, and area under the ROC-curve) were compared for all cases and stratified by location (transitional zone, TZ, peripheral zone, PZ). Inter-reader agreement was assessed by kappa statistics. RESULTS: Inter reader agreement for v2 and v1 was substantial to almost perfect (kappa v2: 0.71, v1: 0.81). Overall, sensitivity between both readers and methods did not differ (p>0.05). Overall specificity was higher using v1 compared to v2 (R1: p=0.0078, R2: p=0.0313) In the TZ, v2 showed a higher AUC (0.81-0.84) compared to v1 (AUC 0.77-0.78). Here, the sensitivity of v2 (87.5-100%) was higher than that of v1 (75%) while v2 specificity (50%-56.3%) was lower than that of v1 (68.8-75%). In the PZ, AUCs were higher using v1 (AUC 0.82-0.83) compared to v2 (AUC 0.61-0.63). The specificity for v1 was higher (43.8-62.3%) than that for v2 (12.5-18.8%) while both v2 and v1 achieved 100% sensitivity. CONCLUSION: PI-RADS v2 and v1 inter-reader agreement is excellent, but their diagnostic performance differs. While v2 appears to be the preferable method for the evaluation of TZ lesions, v1 performs better in the PZ.
Authors: Sonia Gaur; Stephanie Harmon; Rajan T Gupta; Daniel J Margolis; Nathan Lay; Sherif Mehralivand; Maria J Merino; Bradford J Wood; Peter A Pinto; Joanna H Shih; Peter L Choyke; Baris Turkbey Journal: Acad Radiol Date: 2018-04-25 Impact factor: 3.173
Authors: Richard Hoffmann; Callum Logan; Michael O'Callaghan; Kirsten Gormly; Ken Chan; Darren Foreman Journal: Int Urol Nephrol Date: 2017-11-29 Impact factor: 2.370
Authors: Amr Mahran; Kirtishri Mishra; Laura Bukavina; Fredrick Schumacher; Anna Quian; Christina Buzzy; Carvell T Nguyen; Vikas Gulani; Lee E Ponsky Journal: Int Urol Nephrol Date: 2019-05-02 Impact factor: 2.370
Authors: Sonia Gaur; Stephanie Harmon; Sherif Mehralivand; Sandra Bednarova; Brian P Calio; Dordaneh Sugano; Abhinav Sidana; Maria J Merino; Peter A Pinto; Bradford J Wood; Joanna H Shih; Peter L Choyke; Baris Turkbey Journal: J Magn Reson Imaging Date: 2018-03-31 Impact factor: 4.813