BACKGROUND: Emerging evidence indicated that dysregulated long non-coding RNAs (lncRNAs) was implicated in the tumorigenesis and progression. LncRNA TUSC7 was involved in various malignancies. However, the role of TUSC7 in human non-small-cell lung cancer (NSCLC) remains unclear. METHODS: Expression of TUSC7 was analyzed in 112 cases of NSCLC tissues and six lung cancer cell lines by quantitative real-time PCR (qRT-PCR). Then the correlation of TUSC7 expression with clinicopathological features and prognosis was aslo studied. Furthermore, overexpression of TUSC7 was performed and its role in tumor progression was explored. RESULTS: The expression level of TUSC7 was lower in NSCLC tissues and lung cancer cells compared with their normal counterparts. Lower expression of TUSC7 in NSCLC tissues was associated with larger tumor size and higher TNM stage. Patients with lower TUSC7 expression had worse overall survival compared with the high expression cases. Univariate and multivariate analyses suggested that low expression of TUSC7 was an independent poor prognostic indicator for NSCLC patients. Moreover, upregulation of TUSC7 expression could inhibit proliferation of lung cancer cell in vitro. CONCLUSIONS: Our results suggested that TUSC7 was a potential biomarker for NSCLC prognosis, and the dysregulation of TUSC7 may play an important role in the NSCLC progression.
BACKGROUND: Emerging evidence indicated that dysregulated long non-coding RNAs (lncRNAs) was implicated in the tumorigenesis and progression. LncRNA TUSC7 was involved in various malignancies. However, the role of TUSC7 in human non-small-cell lung cancer (NSCLC) remains unclear. METHODS: Expression of TUSC7 was analyzed in 112 cases of NSCLC tissues and six lung cancer cell lines by quantitative real-time PCR (qRT-PCR). Then the correlation of TUSC7 expression with clinicopathological features and prognosis was aslo studied. Furthermore, overexpression of TUSC7 was performed and its role in tumor progression was explored. RESULTS: The expression level of TUSC7 was lower in NSCLC tissues and lung cancer cells compared with their normal counterparts. Lower expression of TUSC7 in NSCLC tissues was associated with larger tumor size and higher TNM stage. Patients with lower TUSC7 expression had worse overall survival compared with the high expression cases. Univariate and multivariate analyses suggested that low expression of TUSC7 was an independent poor prognostic indicator for NSCLCpatients. Moreover, upregulation of TUSC7 expression could inhibit proliferation of lung cancer cell in vitro. CONCLUSIONS: Our results suggested that TUSC7 was a potential biomarker for NSCLC prognosis, and the dysregulation of TUSC7 may play an important role in the NSCLC progression.
Entities:
Keywords:
Long noncoding RNA; TUSC7; function; non-small-cell lung cancer; prognosis
Authors: Lars Henning Schmidt; Dennis Görlich; Tilmann Spieker; Christian Rohde; Martin Schuler; Michael Mohr; Julia Humberg; Tim Sauer; Nils H Thoenissen; Andreas Huge; Reinhard Voss; Alessandro Marra; Andreas Faldum; Carsten Müller-Tidow; Wolfgang E Berdel; Rainer Wiewrodt Journal: J Thorac Oncol Date: 2014-09 Impact factor: 15.609
Authors: Ivan Pasic; Adam Shlien; Adam D Durbin; Dimitrios J Stavropoulos; Berivan Baskin; Peter N Ray; Ana Novokmet; David Malkin Journal: Cancer Res Date: 2010-01-01 Impact factor: 12.701
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