Literature DB >> 27158323

Advanced Glycation End-products and Bone Fractures.

Deepak Vashishth1.   

Abstract

Bone does not turn over uniformly, and becomes susceptible to post-translational modification by non-enzymatic glycation (NEG). NEG of bone causes the formation of advanced glycation end-products (AGEs) and this process is accelerated with aging, diabetes and antiresorptive postmenopausal osteoporosis therapy. Due to the elevated incidence of fracture associated with aging and diabetes, several studies have attempted to measure and evaluate AGEs as biomarkers for fracture risk. Here current methods of estimating AGEs in bone by liquid chromatography and fluorometric assay are summarized and the relationships between AGEs and fracture properties at whole bone, apparent tissue and matrix levels are discussed.

Entities:  

Keywords:  Advanced glycation end-products (AGEs); Bone; Mechanical properties; Non-enzymatic glycation; Pentosidine; Toughness

Year:  2009        PMID： 27158323      PMCID： PMC4856156          DOI： 10.1138/20090390

Source DB:  PubMed          Journal:  IBMS Bonekey        ISSN： 1940-8692


  54 in total

1.  Influence of nonenzymatic glycation on biomechanical properties of cortical bone.

Authors:  D Vashishth; G J Gibson; J I Khoury; M B Schaffler; J Kimura; D P Fyhrie
Journal:  Bone       Date:  2001-02       Impact factor: 4.398

2.  Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation.

Authors:  Ulrich Valcourt; Blandine Merle; Evelyne Gineyts; Stéphanie Viguet-Carrin; Pierre D Delmas; Patrick Garnero
Journal:  J Biol Chem       Date:  2006-12-01       Impact factor: 5.157

3.  Effects of non-enzymatic glycation on cancellous bone fragility.

Authors:  S Y Tang; U Zeenath; D Vashishth
Journal:  Bone       Date:  2006-12-21       Impact factor: 4.398

4.  Bone indentation recovery time correlates with bond reforming time.

Authors:  J B Thompson; J H Kindt; B Drake; H G Hansma; D E Morse; P K Hansma
Journal:  Nature       Date:  2001-12-13       Impact factor: 49.962

5.  Non-enzymic glycation of fibrous collagen: reaction products of glucose and ribose.

Authors:  A J Bailey; T J Sims; N C Avery; E P Halligan
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857

Review 6.  Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance.

Authors:  L Knott; A J Bailey
Journal:  Bone       Date:  1998-03       Impact factor: 4.398

7.  Protein cross-linking by the Maillard reaction. Isolation, characterization, and in vivo detection of a lysine-lysine cross-link derived from methylglyoxal.

Authors:  R H Nagaraj; I N Shipanova; F M Faust
Journal:  J Biol Chem       Date:  1996-08-09       Impact factor: 5.157

8.  Acid-stable fluorescent advanced glycation end products: vesperlysines A, B, and C are formed as crosslinked products in the Maillard reaction between lysine or proteins with glucose.

Authors:  K Nakamura; Y Nakazawa; K Ienaga
Journal:  Biochem Biophys Res Commun       Date:  1997-03-06       Impact factor: 3.575

9.  Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis.

Authors:  P Garnero; E Sornay-Rendu; M C Chapuy; P D Delmas
Journal:  J Bone Miner Res       Date:  1996-03       Impact factor: 6.741

10.  Accelerated age-related browning of human collagen in diabetes mellitus.

Authors:  V M Monnier; R R Kohn; A Cerami
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205
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  24 in total

1.  Bone microarchitecture, biomechanical properties, and advanced glycation end-products in the proximal femur of adults with type 2 diabetes.

Authors:  Lamya Karim; Julia Moulton; Miranda Van Vliet; Kelsey Velie; Ann Robbins; Fatemeh Malekipour; Ayesha Abdeen; Douglas Ayres; Mary L Bouxsein
Journal:  Bone       Date:  2018-05-30       Impact factor: 4.398

2.  Dietary Advanced Glycation End Products Have Sex- and Age-Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice.

Authors:  Svenja Illien-Jünger; Paolo Palacio-Mancheno; William F Kindschuh; Xue Chen; Grazyna E Sroga; Deepak Vashishth; James C Iatridis
Journal:  J Bone Miner Res       Date:  2017-11-27       Impact factor: 6.741

Review 3.  The Effect of Type 2 Diabetes on Bone Biomechanics.

Authors:  Lamya Karim; Taraneh Rezaee; Rachana Vaidya
Journal:  Curr Osteoporos Rep       Date:  2019-10       Impact factor: 5.096

Review 4.  Is Diabetic Skeletal Fragility Associated with Microvascular Complications in Bone?

Authors:  Roberto Jose Fajardo
Journal:  Curr Osteoporos Rep       Date:  2017-02       Impact factor: 5.096

Review 5.  A new perspective on mechanisms governing skeletal complications in type 1 diabetes.

Authors:  Zeynep Seref-Ferlengez; Sylvia O Suadicani; Mia M Thi
Journal:  Ann N Y Acad Sci       Date:  2016-08-29       Impact factor: 5.691

Review 6.  Bone mechanical properties and changes with osteoporosis.

Authors:  Georg Osterhoff; Elise F Morgan; Sandra J Shefelbine; Lamya Karim; Laoise M McNamara; Peter Augat
Journal:  Injury       Date:  2016-06       Impact factor: 2.586

Review 7.  The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality.

Authors:  Jyotiska Chaudhuri; Yasmin Bains; Sanjib Guha; Arnold Kahn; David Hall; Neelanjan Bose; Alejandro Gugliucci; Pankaj Kapahi
Journal:  Cell Metab       Date:  2018-09-04       Impact factor: 27.287

8.  Contributions of Material Properties and Structure to Increased Bone Fragility for a Given Bone Mass in the UCD-T2DM Rat Model of Type 2 Diabetes.

Authors:  Claire Acevedo; Meghan Sylvia; Eric Schaible; James L Graham; Kimber L Stanhope; Lionel N Metz; Bernd Gludovatz; Ann V Schwartz; Robert O Ritchie; Tamara N Alliston; Peter J Havel; Aaron J Fields
Journal:  J Bone Miner Res       Date:  2018-02-22       Impact factor: 6.741

9.  Albuminuria and rapid loss of GFR and risk of new hip and pelvic fractures.

Authors:  Joshua I Barzilay; Peggy Gao; Catherine M Clase; Andrew Mente; Johannes F E Mann; Peter Sleight; Salim Yusuf; Koon K Teo
Journal:  Clin J Am Soc Nephrol       Date:  2012-11-26       Impact factor: 8.237

10.  Induction and rescue of skeletal fragility in a high-fat diet mouse model of type 2 diabetes: An in vivo and in vitro approach.

Authors:  Joan E LLabre; Grażyna E Sroga; Matthew J L Tice; Deepak Vashishth
Journal:  Bone       Date:  2021-12-21       Impact factor: 4.398
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