Literature DB >> 27157898

False Positive Lyme Disease IgM Immunoblots in Children.

Paul M Lantos1, Susan C Lipsett2, Lise E Nigrovic3.   

Abstract

In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive IgM immunoblot but a negative IgG immunoblot test result. Considering that only 71% (95% CI 64%-78%) of patients had Lyme disease, a positive IgM immunoblot alone should be interpreted with caution to avoid over-diagnosis of Lyme disease.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Lyme disease; diagnostic tests; immunoblots; pediatrics

Mesh：

Substances：

Year:  2016        PMID： 27157898      PMCID： PMC4925275          DOI： 10.1016/j.jpeds.2016.04.004

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  14 in total

1.  Prediction of Lyme meningitis in children from a Lyme disease-endemic region: a logistic-regression model using history, physical, and laboratory findings.

Authors:  Robert A Avery; Gary Frank; Joseph J Glutting; Stephen C Eppes
Journal:  Pediatrics       Date:  2006-01       Impact factor: 7.124

2.  Accuracy of IgM immunoblotting to confirm the clinical diagnosis of early Lyme disease.

Authors:  S L Sivak; M E Aguero-Rosenfeld; J Nowakowski; R B Nadelman; G P Wormser
Journal:  Arch Intern Med       Date:  1996-10-14

3.  Validation of a clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis.

Authors:  Keri A Cohn; Amy D Thompson; Samir S Shah; Elizabeth M Hines; Todd W Lyons; Elizabeth J Welsh; Lise E Nigrovic
Journal:  Pediatrics       Date:  2011-12-19       Impact factor: 7.124

4.  Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  1995-08-11       Impact factor: 17.586

5.  Lyme arthritis in children presenting with joint effusions.

Authors:  Matthew D Milewski; Aristides I Cruz; Christopher P Miller; Ashley T Peterson; Brian G Smith
Journal:  J Bone Joint Surg Am       Date:  2011-02-02       Impact factor: 5.284

6.  Lyme borreliosis in Bell's palsy. Long Island Neuroborreliosis Collaborative Study Group.

Authors:  J J Halperin; M Golightly
Journal:  Neurology       Date:  1992-07       Impact factor: 9.910

7.  Synovial fluid findings in children with knee monoarthritis in lyme disease endemic areas.

Authors:  Julia K Deanehan; Peter A Nigrovic; Matthew D Milewski; Sharman P Tan Tanny; Amir A Kimia; Brian G Smith; Lise E Nigrovic
Journal:  Pediatr Emerg Care       Date:  2014-01       Impact factor: 1.454

8.  Prospective validation of a clinical prediction model for Lyme meningitis in children.

Authors:  Aris C Garro; Maia Rutman; Kari Simonsen; Jenifer L Jaeger; Kimberle Chapin; Gregory Lockhart
Journal:  Pediatrics       Date:  2009-05       Impact factor: 7.124

9.  Lyme disease testing by large commercial laboratories in the United States.

Authors:  Alison F Hinckley; Neeta P Connally; James I Meek; Barbara J Johnson; Melissa M Kemperman; Katherine A Feldman; Jennifer L White; Paul S Mead
Journal:  Clin Infect Dis       Date:  2014-05-30       Impact factor: 9.079

10.  Acute pediatric monoarticular arthritis: distinguishing lyme arthritis from other etiologies.

Authors:  Amy Thompson; Rebekah Mannix; Richard Bachur
Journal:  Pediatrics       Date:  2009-03       Impact factor: 7.124
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  18 in total

1.  Evaluation of the C6 Lyme Enzyme Immunoassay for the Diagnosis of Lyme Disease in Children and Adolescents.

Authors:  Susan C Lipsett; John A Branda; Alexander J McAdam; Louis Vernacchio; Caroline D Gordon; Catherine R Gordon; Lise E Nigrovic
Journal:  Clin Infect Dis       Date:  2016-06-28       Impact factor: 9.079

2.  Evaluation of the Modified Two-Tiered Testing Method for Diagnosis of Lyme Disease in Children.

Authors:  Susan C Lipsett; John A Branda; Lise E Nigrovic
Journal:  J Clin Microbiol       Date:  2019-09-24       Impact factor: 5.948

3.  Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease.

Authors:  John A Branda; Klemen Strle; Lise E Nigrovic; Paul M Lantos; Timothy J Lepore; Nitin S Damle; Mary Jane Ferraro; Allen C Steere
Journal:  Clin Infect Dis       Date:  2017-04-15       Impact factor: 9.079

4.  Accuracy of Clinician Suspicion of Lyme Disease in the Emergency Department.

Authors:  Lise E Nigrovic; Jonathan E Bennett; Fran Balamuth; Michael N Levas; Rachel L Chenard; Alexandra B Maulden; Aris C Garro
Journal:  Pediatrics       Date:  2017-12       Impact factor: 7.124

5.  Positive 2-Tiered Lyme Disease Serology is Uncommon in Asymptomatic Children Living in Endemic Areas of the United States.

Authors:  Aris Garro; Jonathan Bennett; Fran Balamuth; Michael N Levas; Desiree Neville; John C Branda; Alexandra B Maulden; Paul M Lantos; Lise E Nigrovic
Journal:  Pediatr Infect Dis J       Date:  2019-05       Impact factor: 2.129

6.  Hip Synovial Fluid Cell Counts in Children From a Lyme Disease Endemic Area.

Authors:  Arianna H Dart; Kenneth A Michelson; Paul L Aronson; Aris C Garro; Thomas J Lee; Kimberly M Glerum; Peter A Nigrovic; Mininder S Kocher; Richard G Bachur; Lise E Nigrovic
Journal:  Pediatrics       Date:  2018-04-18       Impact factor: 7.124

7.  Serologic Response to Borrelia Antigens Varies with Clinical Phenotype in Children and Young Adults with Lyme Disease.

Authors:  Felix A Radtke; Nitya Ramadoss; Aris Garro; Jonathan E Bennett; Michael N Levas; William H Robinson; Peter A Nigrovic; Lise E Nigrovic
Journal:  J Clin Microbiol       Date:  2021-08-11       Impact factor: 5.948

Review 8.  Modified two-tiered testing algorithm for Lyme disease serology: the Canadian context.

Authors: 
Journal:  Can Commun Dis Rep       Date:  2020-05-07

Review 9.  Laboratory Diagnosis of Lyme Borreliosis.

Authors:  John A Branda; Allen C Steere
Journal:  Clin Microbiol Rev       Date:  2021-01-27       Impact factor: 26.132

10.  Serum Epitope Repertoire Analysis Enables Early Detection of Lyme Disease with Improved Sensitivity in an Expandable Multiplex Format.

Authors:  Jack Reifert; Kathy Kamath; Joel Bozekowski; Ewa Lis; Elizabeth J Horn; Dane Granger; Elitza S Theel; John Shon; Jaymie R Sawyer; Patrick S Daugherty
Journal:  J Clin Microbiol       Date:  2021-01-21       Impact factor: 5.948
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