Literature DB >> 30067595

Positive 2-Tiered Lyme Disease Serology is Uncommon in Asymptomatic Children Living in Endemic Areas of the United States.

Aris Garro1, Jonathan Bennett2, Fran Balamuth3, Michael N Levas4, Desiree Neville5, John C Branda6, Alexandra B Maulden7, Paul M Lantos8, Lise E Nigrovic7.   

Abstract

Knowing the frequency of positive Lyme disease serology in children without signs of infection facilitates test interpretation. Of 315 asymptomatic children from Lyme disease endemic regions, 32 had positive or equivocal C6 enzyme-linked immunoassays, but only 5 had positive IgG or IgM supplemental immunoblots (1.6%; 95% confidence interval: 0.7%-3.7%).

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Year:  2019        PMID： 30067595      PMCID： PMC6355375          DOI： 10.1097/INF.0000000000002157

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  10 in total

1.  Blood donor Borrelia burgdorferi sensu lato seroprevalence and history of tick bites at a northern limit of the vector distribution.

Authors:  Dag Hvidsten; Liisa Mortensen; Bjørn Straume; Mirjana Grujic Arsenovic; Anne-Berit Pedersen; Gro Lyngås; Jeremy S Gray; Nils Grude
Journal:  APMIS       Date:  2017-06-14       Impact factor: 3.205

2.  Evaluation of the C6 Lyme Enzyme Immunoassay for the Diagnosis of Lyme Disease in Children and Adolescents.

Authors:  Susan C Lipsett; John A Branda; Alexander J McAdam; Louis Vernacchio; Caroline D Gordon; Catherine R Gordon; Lise E Nigrovic
Journal:  Clin Infect Dis       Date:  2016-06-28       Impact factor: 9.079

3.  Endemic level of Lyme borreliosis in a region of central France: a sero-epidemiologic examination involving blood donors.

Authors:  F Christiann; P Rayet; D B Ngueodjibaye; O Patey; A Godefroy; J Klein; R Lapegue; J F Theron-Le Gargasson; E Godfroid; C Lafaix
Journal:  Eur J Epidemiol       Date:  1997-04       Impact factor: 8.082

4.  Seroprevalence of lyme borreliosis in Scottish blood donors.

Authors:  H Munro; S Mavin; K Duffy; R Evans; L M Jarvis
Journal:  Transfus Med       Date:  2015-04-14       Impact factor: 2.019

5.  False Positive Lyme Disease IgM Immunoblots in Children.

Authors:  Paul M Lantos; Susan C Lipsett; Lise E Nigrovic
Journal:  J Pediatr       Date:  2016-05-04       Impact factor: 4.406

6.  Occupational risk of Lyme disease in endemic areas of New York State.

Authors:  P F Smith; J L Benach; D J White; D F Stroup; D L Morse
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691

7.  Pilot Cross-Sectional Study of Three Zoonoses (Lyme Disease, Tularaemia, Leptospirosis) among Healthy Blood Donors in Eastern Slovakia.

Authors:  Ľubica Zákutná; Erik Dorko; Kvetoslava Rimárová; Marianna Kizeková
Journal:  Cent Eur J Public Health       Date:  2015-06       Impact factor: 1.163

8.  Prospective assessment of Lyme disease in a school-aged population in Connecticut.

Authors:  H M Feder; M A Gerber; M L Cartter; V Sikand; P J Krause
Journal:  J Infect Dis       Date:  1995-05       Impact factor: 5.226

9.  Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease.

Authors:  Gary P Wormser; Martin Schriefer; Maria E Aguero-Rosenfeld; Andrew Levin; Allen C Steere; Robert B Nadelman; John Nowakowski; Adriana Marques; Barbara J B Johnson; J Stephen Dumler
Journal:  Diagn Microbiol Infect Dis       Date:  2012-10-11       Impact factor: 2.803

10.  Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group.

Authors:  A C Steere; V K Sikand; F Meurice; D L Parenti; E Fikrig; R T Schoen; J Nowakowski; C H Schmid; S Laukamp; C Buscarino; D S Krause
Journal:  N Engl J Med       Date:  1998-07-23       Impact factor: 91.245
  10 in total
  2 in total

1.  Evaluation of the Modified Two-Tiered Testing Method for Diagnosis of Lyme Disease in Children.

Authors:  Susan C Lipsett; John A Branda; Lise E Nigrovic
Journal:  J Clin Microbiol       Date:  2019-09-24       Impact factor: 5.948

2.  Pediatric Lyme Disease Biobank, United States, 2015-2020.

Authors:  Lise E Nigrovic; Desire N Neville; Fran Balamuth; Michael N Levas; Jonathan E Bennett; Anupam B Kharbanda; Amy D Thompson; John A Branda; Aris C Garro
Journal:  Emerg Infect Dis       Date:  2020-12       Impact factor: 6.883
  2 in total

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