BACKGROUND: Plant food allergies associated with lipid transfer protein (LTP) have been widely described in the Mediterranean Basin. OBJECTIVE: The aim of this work was to describe the clinical profile and pollen sensitization of plant food- allergic patients sensitized to LTP in a non-Mediterranean area. METHODS: Patients with clear IgE-mediated symptoms associated with plant foods and a positive skin prick test (SPT) to Pru p 3 were included in a prospective study in the north of Spain. Reported symptoms were analyzed together with a battery of food and pollen SPTs and specific IgE components by ISAC microarray. Cross-inhibition studies were performed by ImmunoCAP with plane tree, mugwort and rPru p 3. RESULTS: Among the 72 patients included, the most frequent food allergy reported was to peaches (69%) followed by nuts (walnuts 55%, peanuts 54% and hazelnuts 43%). Most patients suffered from symptoms with multiple plant foods (a median of 6 foods per patient). Regarding the patients' pollen sensitization, 36% were sensitized to mugwort pollen (72% showing sIgE to Art v 3), 33% to grass pollen and 24% to plane tree pollen (94% with sIgE to Pla a 3). Inhibition studies showed that specific IgEs against mugwort and plane tree pollen are inhibited by Pru p 3 in a strong manner, whereas Pru p 3 was less inhibited by pollen extracts. CONCLUSIONS: LTP syndrome occurs in a non-Mediterranean area and is related to multiple sensitizations to foods and pollens such as plane tree and mugwort. In these pollen sensitizations, Pru p 3 seems to be the primary sensitizer.
BACKGROUND: Plant food allergies associated with lipid transfer protein (LTP) have been widely described in the Mediterranean Basin. OBJECTIVE: The aim of this work was to describe the clinical profile and pollen sensitization of plant food- allergicpatients sensitized to LTP in a non-Mediterranean area. METHODS:Patients with clear IgE-mediated symptoms associated with plant foods and a positive skin prick test (SPT) to Pru p 3 were included in a prospective study in the north of Spain. Reported symptoms were analyzed together with a battery of food and pollen SPTs and specific IgE components by ISAC microarray. Cross-inhibition studies were performed by ImmunoCAP with plane tree, mugwort and rPru p 3. RESULTS: Among the 72 patients included, the most frequent food allergy reported was to peaches (69%) followed by nuts (walnuts 55%, peanuts 54% and hazelnuts 43%). Most patients suffered from symptoms with multiple plant foods (a median of 6 foods per patient). Regarding the patients' pollen sensitization, 36% were sensitized to mugwort pollen (72% showing sIgE to Art v 3), 33% to grass pollen and 24% to plane tree pollen (94% with sIgE to Pla a 3). Inhibition studies showed that specific IgEs against mugwort and plane tree pollen are inhibited by Pru p 3 in a strong manner, whereas Pru p 3 was less inhibited by pollen extracts. CONCLUSIONS: LTP syndrome occurs in a non-Mediterranean area and is related to multiple sensitizations to foods and pollens such as plane tree and mugwort. In these pollen sensitizations, Pru p 3 seems to be the primary sensitizer.
Authors: Martina Di Muzio; Sabrina Wildner; Sara Huber; Michael Hauser; Eva Vejvar; Werner Auzinger; Christof Regl; Josef Laimer; Danila Zennaro; Nicole Wopfer; Christian G Huber; Ronald van Ree; Adriano Mari; Peter Lackner; Fatima Ferreira; Mario Schubert; Gabriele Gadermaier Journal: J Biol Chem Date: 2020-12-18 Impact factor: 5.157
Authors: Martina Di Muzio; Sabrina Wildner; Sara Huber; Michael Hauser; Eva Vejvar; Werner Auzinger; Christof Regl; Josef Laimer; Danila Zennaro; Nicole Wopfner; Christian G Huber; Ronald van Ree; Adriano Mari; Peter Lackner; Fatima Ferreira; Mario Schubert; Gabriele Gadermaier Journal: J Biol Chem Date: 2020-10-09 Impact factor: 5.157
Authors: Isabel J Skypala; Ricardo Asero; Domingo Barber; Lorenzo Cecchi; Arazeli Diaz Perales; Karin Hoffmann-Sommergruber; Elide A Pastorello; Ines Swoboda; Joan Bartra; Didier G Ebo; Margaretha A Faber; Montserrat Fernández-Rivas; Francesca Gomez; Anastasios P Konstantinopoulos; Olga Luengo; Ronald van Ree; Enrico Scala; Stephen J Till Journal: Clin Transl Allergy Date: 2021-05-18 Impact factor: 5.871
Authors: Stephanie Eichhorn; Angelika Hörschläger; Markus Steiner; Josef Laimer; Bettina M Jensen; Serge A Versteeg; Isabel Pablos; Peter Briza; Laurian Jongejan; Neil Rigby; Juan A Asturias; Antonio Portolés; Montserrat Fernandez-Rivas; Nikolaos G Papadopoulos; Adriano Mari; Lars K Poulsen; Peter Lackner; Ronald van Ree; Fatima Ferreira; Gabriele Gadermaier Journal: Mol Nutr Food Res Date: 2019-06-26 Impact factor: 5.914