Marek A Mikulski1, Alicia K Gerke2, John D Newell3, Ann M Murray4, Carmen J Smith5, Laurence J Fuortes1. 1. a Department of Occupational and Environmental Health, College of Public Health , The University of Iowa , 2213 Westlawn, Iowa City , IA 52242 , USA. 2. b Department of Internal Medicine , The University of Iowa Hospitals and Clinics , Iowa City , IA , USA. 3. c Department of Radiology , The University of Iowa Hospitals and Clinics , Iowa City , IA , USA. 4. d Roy J. and Lucille Carver College of Medicine, The University of Iowa , Iowa City , IA , USA. 5. e Department of Biostatistics , College of Public Health, The University of Iowa , Iowa City , IA , USA.
Abstract
BACKGROUND: Although the relation between radiographic abnormalities and spirometric impairment in people with asbestosis has been studied extensively, the extent of spirometric impairment associated with milder radiographic abnormalities is not established. OBJECTIVE: To test associations between mild radiographic abnormalities and Lower Limit of Normal (LLN)-based spirometry interpretation. METHODS: Spirometry and CXRs were collected for 1,026 at low risk of exposure to pneumoconiotic agents participants in a medical screening program. RESULTS: Individuals with each type of isolated or combined International Labour Organization (ILO) abnormalities had up to over sixfold statistically significant increase in odds of LLN-based restrictive pattern physiology (OR = 1.96, 95%CI 1.03-3.73 for parenchymal to OR = 6.09, 95%CI 1.94-19.10 for parenchymal and pleural) compared to those with normal films. CONCLUSIONS: The findings from this study confirm the association of mild profusion abnormalities with clinically relevant, LLN-based lung function abnormalities.
BACKGROUND: Although the relation between radiographic abnormalities and spirometric impairment in people with asbestosis has been studied extensively, the extent of spirometric impairment associated with milder radiographic abnormalities is not established. OBJECTIVE: To test associations between mild radiographic abnormalities and Lower Limit of Normal (LLN)-based spirometry interpretation. METHODS: Spirometry and CXRs were collected for 1,026 at low risk of exposure to pneumoconiotic agents participants in a medical screening program. RESULTS: Individuals with each type of isolated or combined International Labour Organization (ILO) abnormalities had up to over sixfold statistically significant increase in odds of LLN-based restrictive pattern physiology (OR = 1.96, 95%CI 1.03-3.73 for parenchymal to OR = 6.09, 95%CI 1.94-19.10 for parenchymal and pleural) compared to those with normal films. CONCLUSIONS: The findings from this study confirm the association of mild profusion abnormalities with clinically relevant, LLN-based lung function abnormalities.
Entities:
Keywords:
ILO; Lower limit of normal; Pneumoconiosis; Spirometric abnormalities; Spirometry
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