Literature DB >> 21298695

Risk of beryllium sensitization in a low-exposed former nuclear weapons cohort from the Cold War era.

Marek A Mikulski1, Stephanie A Leonard, Wayne T Sanderson, Patrick G Hartley, Nancy L Sprince, Laurence J Fuortes.   

Abstract

BACKGROUND: The nuclear weapons industry has long been known as a source of beryllium exposure.
METHODS: A total of 1,004 former workers from a nuclear weapons assembly site in the Midwest were screened for sensitization to beryllium (BeS). The screenings were part of the Department of Energy (DOE) Former Worker Program established in 1996.
RESULTS: Twenty-three (2.3%) workers were found sensitized to beryllium and this prevalence was comparable to other DOE sites. Occasional, direct exposure to beryllium through machining and grinding of copper-beryllium (Cu-Be) 2% alloy tools was found to increase the risk of sensitization compared to background exposure (OR = 3.83; 95% CI: 1.04-14.03) with a statistically significant trend (P = 0.03) revealing that particular jobs are associated with sensitization. Exposure potential in this study was estimated based on job titles and not personal exposure information.
CONCLUSIONS: These results confirm the need to screen workers using beryllium alloy tools in other industries and for consideration of altering work practices.
Copyright © 2010 Wiley-Liss, Inc.

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Year:  2010        PMID: 21298695     DOI: 10.1002/ajim.20913

Source DB:  PubMed          Journal:  Am J Ind Med        ISSN: 0271-3586            Impact factor:   2.214


  3 in total

Review 1.  The role of lymphocyte proliferation tests in assessing occupational sensitization and disease.

Authors:  Stella E Hines; Karin Pacheco; Lisa A Maier
Journal:  Curr Opin Allergy Clin Immunol       Date:  2012-04

2.  Illness absences among beryllium sensitized workers.

Authors:  Janice P Watkins; Elizabeth D Ellis; David J Girardi; Donna L Cragle; Bonnie S Richter
Journal:  Am J Public Health       Date:  2014-09-11       Impact factor: 9.308

3.  Lower limit of normal based spirometric abnormalities associated with radiographic abnormality in an elderly cohort at low risk for exposure.

Authors:  Marek A Mikulski; Alicia K Gerke; John D Newell; Ann M Murray; Carmen J Smith; Laurence J Fuortes
Journal:  Int J Occup Environ Health       Date:  2016-05-04
  3 in total

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