Literature DB >> 27139487

Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense.

Keisuke Suganuma1, Albertus Eka Yudistira Sarwono2, Shinya Mitsuhashi2, Marcin Jąkalski3, Tadashi Okada4, Molefe Nthatisi1, Junya Yamagishi5, Makoto Ubukata2, Noboru Inoue6.   

Abstract

This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense The proliferation of T. congolense was completely inhibited by adding <1 μM MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27139487      PMCID： PMC4914658          DOI： 10.1128/AAC.02816-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

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3.  Trypanosoma brucei brucei crosses the blood-brain barrier while tight junction proteins are preserved in a rat chronic disease model.

Authors:  C Mulenga; J D Mhlanga; K Kristensson; B Robertson
Journal:  Neuropathol Appl Neurobiol       Date:  2001-02       Impact factor: 8.090

4.  Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives.

Authors:  Shinya Mitsuhashi; Junichi Takenaka; Katsushige Iwamori; Noriyuki Nakajima; Makoto Ubukata
Journal:  Bioorg Med Chem       Date:  2010-09-18       Impact factor: 3.641

5.  Mycophenolic acid, mycophenolate mofetil, mizoribine, ribavirin, and 7-nitroindole inhibit propagation of Babesia parasites by targeting inosine 5'-monophosphate dehydrogenase.

Authors:  Shinuo Cao; Gabriel Oluga Aboge; Mohamad Alaa Terkawi; Mo Zhou; Ketsarin Kamyingkird; Paul Franck Adjou Moumouni; Tatsunori Masatani; Ikuo Igarashi; Yoshifumi Nishikawa; Hiroshi Suzuki; Xuenan Xuan
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Authors:  Vincent Delespaux; Hunduma Dinka; Justin Masumu; Peter Van den Bossche; Stanny Geerts
Journal:  Drug Resist Updat       Date:  2008-11-06       Impact factor: 18.500

7.  Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design.

Authors:  Nwakaso N Umejiego; Catherine Li; Thomas Riera; Lizbeth Hedstrom; Boris Striepen
Journal:  J Biol Chem       Date:  2004-07-21       Impact factor: 5.157

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Journal:  Acta Trop       Date:  1984-09       Impact factor: 3.112

Review 9.  The trypanosomiases.

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Authors:  Melissa L Sykes; Jonathan B Baell; Marcel Kaiser; Eric Chatelain; Sarah R Moawad; Danny Ganame; Jean-Robert Ioset; Vicky M Avery
Journal:  PLoS Negl Trop Dis       Date:  2012-11-29
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Journal:  Parasitol Res       Date:  2019-05-04       Impact factor: 2.289

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Journal:  Parasit Vectors       Date:  2016-08-31       Impact factor: 3.876

3.  Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides.

Authors:  Antonio E Vidal; Miriam Yagüe-Capilla; Blanca Martínez-Arribas; Daniel García-Caballero; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Journal:  Sci Rep       Date:  2022-04-18       Impact factor: 4.996

4.  Screening a Natural Product-Based Library against Kinetoplastid Parasites.

Authors:  Bilal Zulfiqar; Amy J Jones; Melissa L Sykes; Todd B Shelper; Rohan A Davis; Vicky M Avery
Journal:  Molecules       Date:  2017-10-12       Impact factor: 4.411

5.  Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.

Authors:  Albertus Eka Yudistira Sarwono; Shinya Mitsuhashi; Mohammad Hazzaz Bin Kabir; Kengo Shigetomi; Tadashi Okada; Fumina Ohsaka; Satoko Otsuguro; Katsumi Maenaka; Makoto Igarashi; Kentaro Kato; Makoto Ubukata
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