Sonja Rutten1, Peter M van der Ven2, Daniel Weintraub3, Gregory M Pontone4, Albert F G Leentjens5, Henk W Berendse6, Ysbrand D van der Werf7, Odile A van den Heuvel8. 1. Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands; Department of Anatomy & Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands. Electronic address: s.rutten@vumc.nl. 2. Department of Epidemiology & Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands. 3. Section of Geriatric Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, United States. 4. Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, United States. 5. Department of Psychiatry, Maastricht University Medical Center, Maastricht, The Netherlands. 6. Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The Netherlands. 7. Department of Anatomy & Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The Netherlands. 8. Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands; Department of Anatomy & Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The Netherlands.
Abstract
AIM: Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD. METHODS: The participants of this two-year prospective cohort study were recently diagnosed PD patients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline. The primary outcome measure was anxiety, as measured with the State-Trait Anxiety Inventory (STAI). Covariates were age, gender, family history, striatal dopamine transporter binding ratios, and severity of motor and non-motor features of PD at baseline. Data were analyzed using a mixed model analysis. RESULTS: Inclusion criteria were met by 306 subjects. An increase in STAI total score was predicted by older age, lower score on the Montreal Cognitive Assessment, and the presence of a probable REM-sleep behavior disorder (RBD) at baseline. A decrease in STAI total score over time was predicted by a higher baseline score on the 15-item Geriatric Depression Scale, compulsive behavior at baseline and a family history of PD. CONCLUSIONS: More severe baseline anxiety was associated with compulsive behavior and depressive symptoms. These symptoms had a parallel course, showing a decrease over time. An increase in anxiety was predicted by older age, worse cognitive functioning and the presence of RBD. Our findings, when replicated in a sample of PD patients in a more advanced disease stage, could provide starting points for prevention of anxiety in PD patients.
AIM: Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD. METHODS: The participants of this two-year prospective cohort study were recently diagnosed PDpatients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline. The primary outcome measure was anxiety, as measured with the State-Trait Anxiety Inventory (STAI). Covariates were age, gender, family history, striatal dopamine transporter binding ratios, and severity of motor and non-motor features of PD at baseline. Data were analyzed using a mixed model analysis. RESULTS: Inclusion criteria were met by 306 subjects. An increase in STAI total score was predicted by older age, lower score on the Montreal Cognitive Assessment, and the presence of a probable REM-sleep behavior disorder (RBD) at baseline. A decrease in STAI total score over time was predicted by a higher baseline score on the 15-item Geriatric Depression Scale, compulsive behavior at baseline and a family history of PD. CONCLUSIONS: More severe baseline anxiety was associated with compulsive behavior and depressive symptoms. These symptoms had a parallel course, showing a decrease over time. An increase in anxiety was predicted by older age, worse cognitive functioning and the presence of RBD. Our findings, when replicated in a sample of PDpatients in a more advanced disease stage, could provide starting points for prevention of anxiety in PDpatients.
Authors: Albert F G Leentjens; Kathy Dujardin; Laura Marsh; Pablo Martinez-Martin; Irene H Richard; Sergio E Starkstein Journal: Mov Disord Date: 2011-02-10 Impact factor: 10.338
Authors: Daniel Weintraub; Andrew B Newberg; Mark S Cary; Andrew D Siderowf; Paul J Moberg; Galit Kleiner-Fisman; John E Duda; Matthew B Stern; David Mozley; Ira R Katz Journal: J Nucl Med Date: 2005-02 Impact factor: 10.057
Authors: Daniel Weintraub; Staci Hoops; Judy A Shea; Kelly E Lyons; Rajesh Pahwa; Erika D Driver-Dunckley; Charles H Adler; Marc N Potenza; Janis Miyasaki; Andrew D Siderowf; John E Duda; Howard I Hurtig; Amy Colcher; Stacy S Horn; Matthew B Stern; Valerie Voon Journal: Mov Disord Date: 2009-07-30 Impact factor: 10.338
Authors: Michal Rolinski; Konrad Szewczyk-Krolikowski; Paul R Tomlinson; Kannan Nithi; Kevin Talbot; Yoav Ben-Shlomo; Michele Tm Hu Journal: J Neurol Neurosurg Psychiatry Date: 2013-11-01 Impact factor: 10.154
Authors: Jacob D Jones; Natalie E Kurniadi; Taylor P Kuhn; Sarah M Szymkowicz; Joseph Bunch; Elizabeth Rahmani Journal: Neuropsychology Date: 2019-07-25 Impact factor: 3.295
Authors: Jessie S Gibson; Joseph L Flanigan; James T Patrie; W Alex Dalrymple; Madaline B Harrison Journal: Neurol Sci Date: 2022-10-11 Impact factor: 3.830
Authors: Martinus P G Broen; A F G Leentjens; J T Hinkle; A J H Moonen; M L Kuijf; N M Fischer; K Perepezko; A Bakker; G M Pontone Journal: J Geriatr Psychiatry Neurol Date: 2018-03-11 Impact factor: 2.680